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Osr2 odd-skipped related 2 [ Mus musculus (house mouse) ]

Gene ID: 107587, updated on 13-Feb-2024

Summary

Official Symbol
Osr2provided by MGI
Official Full Name
odd-skipped related 2provided by MGI
Primary source
MGI:MGI:1930813
See related
Ensembl:ENSMUSG00000022330 AllianceGenome:MGI:1930813
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Osr2A; Osr2B; 5430409I15Rik
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including animal organ development; embryonic limb morphogenesis; and positive regulation of macromolecule metabolic process. Acts upstream of or within several processes, including embryonic skeletal system morphogenesis; kidney development; and negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including branchial arch; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Orthologous to human OSR2 (odd-skipped related transciption factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in ovary adult (RPKM 68.7), subcutaneous fat pad adult (RPKM 65.0) and 10 other tissues See more
Orthologs
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Genomic context

See Osr2 in Genome Data Viewer
Location:
15 B3.1; 15 14.46 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (35296244..35303451)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (35296098..35303305)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene serine/threonine kinase 3 Neighboring gene STARR-seq mESC enhancer starr_38336 Neighboring gene predicted gene, 52204 Neighboring gene STARR-seq mESC enhancer starr_38337 Neighboring gene STARR-seq mESC enhancer starr_38338 Neighboring gene predicted gene, 52178 Neighboring gene predicted gene, 33497 Neighboring gene STARR-seq mESC enhancer starr_38340 Neighboring gene STARR-seq mESC enhancer starr_38341 Neighboring gene cDNA sequence BC048602 Neighboring gene predicted gene, 33584

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Endonuclease-mediated (2) 

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in bone morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chondrocyte differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in embryo development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in embryo development ending in birth or egg hatching IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in embryonic digit morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in embryonic forelimb morphogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in embryonic forelimb morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in embryonic hindlimb morphogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in embryonic hindlimb morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in embryonic skeletal joint development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in embryonic skeletal joint morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in embryonic skeletal limb joint morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within embryonic skeletal system morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in eyelid development in camera-type eye IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in head development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mesonephros development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in metanephros development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in middle ear morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in odontogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in osteoblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of bone mineralization IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of gastrulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of stem cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in pronephros development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in roof of mouth development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of stem cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in urogenital system development IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein odd-skipped-related 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368665.1NP_001355594.1  protein odd-skipped-related 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC116596
    Consensus CDS
    CCDS88748.1
    UniProtKB/Swiss-Prot
    Q8BPV6, Q91V54, Q91ZD1
    Related
    ENSMUSP00000154286.2, ENSMUST00000228152.2
    Conserved Domains (3) summary
    COG5048
    Location:251312
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:174194
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:186211
    zf-H2C2_2; Zinc-finger double domain
  2. NM_054049.3NP_473390.1  protein odd-skipped-related 2 isoform 2

    See identical proteins and their annotated locations for NP_473390.1

    Status: VALIDATED

    Source sequence(s)
    AC116596
    Consensus CDS
    CCDS27422.1
    UniProtKB/Swiss-Prot
    Q91ZD1
    Related
    ENSMUSP00000022952.5, ENSMUST00000022952.6
    Conserved Domains (2) summary
    sd00017
    Location:174194
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:214237
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    35296244..35303451
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_004938784.1 RNA Sequence