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Ovol2 ovo like zinc finger 2 [ Mus musculus (house mouse) ]

Gene ID: 107586, updated on 12-May-2024

Summary

Official Symbol
Ovol2provided by MGI
Official Full Name
ovo like zinc finger 2provided by MGI
Primary source
MGI:MGI:1338039
See related
Ensembl:ENSMUSG00000037279 AllianceGenome:MGI:1338039
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MOVO; Ovo2; M-OVO; movo2; Zfp339; M-OVO-A; M-OVO-B; 1700108N11Rik; 1810007D21Rik
Summary
Enables DNA binding activity; DNA-binding transcription factor activity, RNA polymerase II-specific; and chromatin binding activity. Involved in several processes, including negative regulation of epithelial to mesenchymal transition; regulation of SMAD protein signal transduction; and regulation of gene expression. Acts upstream of or within several processes, including circulatory system development; embryonic morphogenesis; and regulation of transcription, DNA-templated. Located in nucleus. Is expressed in several structures, including early conceptus; genitourinary system; gut; head surface ectoderm; and otocyst. Human ortholog(s) of this gene implicated in posterior polymorphous corneal dystrophy 1. Orthologous to human OVOL2 (ovo like zinc finger 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 23.4), colon adult (RPKM 9.7) and 8 other tissues See more
Orthologs
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Genomic context

See Ovol2 in Genome Data Viewer
Location:
2 G1; 2 70.99 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (144147095..144174000, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (144305175..144332080, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene sorting nexin 5 Neighboring gene STARR-positive B cell enhancer ABC_E5994 Neighboring gene STARR-positive B cell enhancer ABC_E5995 Neighboring gene small nucleolar RNA, C/D box 17 Neighboring gene STARR-seq mESC enhancer starr_05908 Neighboring gene mitochondrial genome maintenance exonuclease 1 Neighboring gene STARR-positive B cell enhancer ABC_E9536 Neighboring gene predicted gene, 34181 Neighboring gene peptidylprolyl isomerase A pseudogene 2_1789.1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within dorsal/ventral pattern formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic digestive tract morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within endocardium formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in epidermal cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in epidermal cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within epidermis development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within heart looping IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within heart trabecula formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within labyrinthine layer blood vessel development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of SMAD protein signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of epithelial to mesenchymal transition IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of epithelial to mesenchymal transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of keratinocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of stem cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of transcription by competitive promoter binding ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within neural crest cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neural fold formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of keratinocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of keratinocyte proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of keratinocyte proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
transcription factor Ovo-like 2
Names
MOVO-B zinc finger protein
MOVO-C zinc finger protein
OVO homolog-like 2
ovo-like 2
zinc finger OVO2
zinc finger protein 339
zinc finger protein mOVO

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026924.3NP_081200.2  transcription factor Ovo-like 2 isoform A

    See identical proteins and their annotated locations for NP_081200.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (A) represents the longer transcript and encodes the longer isoform (A).
    Source sequence(s)
    AL808123
    Consensus CDS
    CCDS16817.1
    UniProtKB/Swiss-Prot
    Q505Q7, Q6F661, Q8CIV6, Q8CIV7, Q8K0D6, Q9D949
    UniProtKB/TrEMBL
    Q3TIV4
    Related
    ENSMUSP00000044026.4, ENSMUST00000037423.4
    Conserved Domains (3) summary
    PHA00733
    Location:115199
    PHA00733; hypothetical protein
    sd00017
    Location:120140
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:160185
    zf-H2C2_2; Zinc-finger double domain
  2. NM_152947.3NP_694455.2  transcription factor Ovo-like 2 isoform B

    See identical proteins and their annotated locations for NP_694455.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (B) differs in the 5' UTR and coding sequence compared to variant A. The resulting isoform (B) has a shorter and distinct N-terminus compared to isoform A.
    Source sequence(s)
    AL808123
    Consensus CDS
    CCDS16818.1
    UniProtKB/TrEMBL
    Q3TIV4
    Related
    ENSMUSP00000099460.4, ENSMUST00000103171.10
    Conserved Domains (3) summary
    PHA00733
    Location:82166
    PHA00733; hypothetical protein
    sd00017
    Location:87107
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:127152
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    144147095..144174000 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498544.4XP_006498607.1  transcription factor Ovo-like 2 isoform X1

    Conserved Domains (3) summary
    COG5189
    Location:3988
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:1737
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:2954
    zf-H2C2_2; Zinc-finger double domain