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FUT9 fucosyltransferase 9 [ Homo sapiens (human) ]

Gene ID: 10690, updated on 11-Jun-2021

Summary

Official Symbol
FUT9provided by HGNC
Official Full Name
fucosyltransferase 9provided by HGNC
Primary source
HGNC:HGNC:4020
See related
Ensembl:ENSG00000172461 MIM:606865
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Fuc-TIX
Summary
The protein encoded by this gene belongs to the glycosyltransferase family. It is localized to the golgi, and catalyzes the last step in the biosynthesis of Lewis X (LeX) antigen, the addition of a fucose to precursor polysaccharides. This protein is one of the few fucosyltransferases that synthesizes the LeX oligosaccharide (CD15) expressed in the organ buds progressing in mesenchyma during embryogenesis. It is also responsible for the expression of CD15 in mature granulocytes. A common haplotype of this gene has also been associated with susceptibility to placental malaria infection. [provided by RefSeq, Nov 2011]
Expression
Biased expression in brain (RPKM 9.0), stomach (RPKM 7.9) and 2 other tissues See more
Orthologs
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Genomic context

See FUT9 in Genome Data Viewer
Location:
6q16.1
Exon count:
5
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (96015974..96215612)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (96463850..96663488)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986543 Neighboring gene uncharacterized LOC107986626 Neighboring gene keratin 18 pseudogene 50 Neighboring gene uncharacterized LOC105377905 Neighboring gene RNA, 7SL, cytoplasmic 797, pseudogene Neighboring gene UFL1 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Biological insights from 108 schizophrenia-associated genetic loci.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in Golgi apparatus TAS
Traceable Author Statement
more info
PubMed 
located_in Golgi membrane TAS
Traceable Author Statement
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
PubMed 
located_in trans-Golgi network membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9
Names
alpha-(1,3)-fucosyltransferase 9
fucT-IX
fucosyltransferase 9 (alpha (1,3) fucosyltransferase)
fucosyltransferase IX
galactoside 3-L-fucosyltransferase
NP_006572.2
XP_011533685.1
XP_011533687.1
XP_016865677.1
XP_016865679.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006581.4NP_006572.2  4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9

    See identical proteins and their annotated locations for NP_006572.2

    Status: REVIEWED

    Source sequence(s)
    AL512406, BC036101, CK299829, CK904220
    Consensus CDS
    CCDS5033.1
    UniProtKB/Swiss-Prot
    Q9Y231
    Related
    ENSP00000302599.4, ENST00000302103.6
    Conserved Domains (2) summary
    pfam00852
    Location:185354
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:62169
    Glyco_tran_10_N; Fucosyltransferase, N-terminal

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    96015974..96215612
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017010190.1XP_016865679.1  4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9 isoform X1

    UniProtKB/Swiss-Prot
    Q9Y231
    Conserved Domains (2) summary
    pfam00852
    Location:185354
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:62169
    Glyco_tran_10_N; Fucosyltransferase, N-terminal
  2. XM_011535385.2XP_011533687.1  4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9 isoform X1

    See identical proteins and their annotated locations for XP_011533687.1

    UniProtKB/Swiss-Prot
    Q9Y231
    Conserved Domains (2) summary
    pfam00852
    Location:185354
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:62169
    Glyco_tran_10_N; Fucosyltransferase, N-terminal
  3. XM_011535383.2XP_011533685.1  4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9 isoform X1

    See identical proteins and their annotated locations for XP_011533685.1

    UniProtKB/Swiss-Prot
    Q9Y231
    Conserved Domains (2) summary
    pfam00852
    Location:185354
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:62169
    Glyco_tran_10_N; Fucosyltransferase, N-terminal
  4. XM_017010188.1XP_016865677.1  4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9 isoform X1

    UniProtKB/Swiss-Prot
    Q9Y231
    Conserved Domains (2) summary
    pfam00852
    Location:185354
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:62169
    Glyco_tran_10_N; Fucosyltransferase, N-terminal
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