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IGF2BP1 insulin like growth factor 2 mRNA binding protein 1 [ Homo sapiens (human) ]

Gene ID: 10642, updated on 20-Feb-2024

Summary

Official Symbol
IGF2BP1provided by HGNC
Official Full Name
insulin like growth factor 2 mRNA binding protein 1provided by HGNC
Primary source
HGNC:HGNC:28866
See related
Ensembl:ENSG00000159217 MIM:608288; AllianceGenome:HGNC:28866
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IMP1; ZBP1; CRDBP; IMP-1; CRD-BP; VICKZ1
Summary
This gene encodes a member of the insulin-like growth factor 2 mRNA-binding protein family. The protein encoded by this gene contains four K homology domains and two RNA recognition motifs. It functions by binding to the mRNAs of certain genes, including insulin-like growth factor 2, beta-actin and beta-transducin repeat-containing protein, and regulating their translation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
Annotation information
Note: ZBP1 (GeneID: 81030) and IGF2BP1 (GeneID:10642) share the ZBP1 symbol/alias in common. ZBP1 is a widely used alternative name for insulin-like growth factor 2 mRNA binding protein 1 (IGF2BP1), which can be confused with the official symbol for ZBP1, Z-DNA binding protein 1 (ZBP1). [09 Aug 2021]
Expression
Biased expression in testis (RPKM 3.6), placenta (RPKM 2.9) and 1 other tissue See more
Orthologs
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Genomic context

See IGF2BP1 in Genome Data Viewer
Location:
17q21.32
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (48996558..49056145)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (49859908..49919501)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (47074747..47133507)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA U13 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:47041863-47042412 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:47043544-47044044 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:47044045-47044545 Neighboring gene gastric inhibitory polypeptide Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8665 Neighboring gene uncharacterized LOC124904020 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:47081123-47081644 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:47089629-47090182 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:47090183-47090738 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:47091293-47091848 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:47092958-47093511 Neighboring gene Sharpr-MPRA regulatory region 671 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:47110305-47110846 Neighboring gene RNA, U6 small nuclear 826, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:47126439-47127348 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:47135543-47136044 Neighboring gene NANOG hESC enhancer GRCh37_chr17:47163998-47164523 Neighboring gene B4GALNT2 pseudogene 1 Neighboring gene uncharacterized LOC124904021 Neighboring gene beta-1,4-N-acetyl-galactosaminyltransferase 2 (SID blood group)

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study of primary tooth eruption identifies pleiotropic loci associated with height and craniofacial distances.
EBI GWAS Catalog
Genome-wide association study reveals multiple loci associated with primary tooth development during infancy.
EBI GWAS Catalog
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify insulin-like growth factor 2 Mrna binding protein 1 (IGF2BP1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify insulin-like growth factor 2 Mrna binding protein 1 (IGF2BP1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify insulin-like growth factor 2 Mrna binding protein 1 (IGF2BP1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify insulin-like growth factor 2 Mrna binding protein 1 (IGF2BP1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
gag Expression of IMP1 protein decreases HIV-1 infectivity, inhibits viral RNA packaging, and impedes the assembly and processing of Gag on cellular membrane PubMed
gag Gag-IMP1 interaction requires the second zinc finger of the NC domain (residues 390-449) of Gag and the KH3 (residues 409-458) and KH4 (residues 490-540) domains of IMP1 PubMed
gag IMP1 co-localizes with HIV-1 Gag in cells and is packaged into virus particles via its interaction with HIV-1 Gag PubMed
Rev rev IMP1 interacts with HIV-1 Rev and has the ability of relocating Rev from the nucleus to the cytoplasm PubMed
nucleocapsid gag Gag-IMP1 interaction requires the second zinc finger of the NC domain (residues 390-449) of Gag and the KH3 (residues 409-458) and KH4 (residues 490-540) domains of IMP1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables N6-methyladenosine-containing RNA reader activity IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA binding HDA PubMed 
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables mRNA 3'-UTR binding IDA
Inferred from Direct Assay
more info
PubMed 
enables mRNA 5'-UTR binding IDA
Inferred from Direct Assay
more info
PubMed 
enables mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables translation regulator activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of CRD-mediated mRNA stability complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of CRD-mediated mRNA stability complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in P-body IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in dendritic spine IEA
Inferred from Electronic Annotation
more info
 
located_in filopodium IEA
Inferred from Electronic Annotation
more info
 
located_in growth cone IEA
Inferred from Electronic Annotation
more info
 
located_in lamellipodium IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
part_of ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
insulin-like growth factor 2 mRNA-binding protein 1
Names
IGF-II mRNA-binding protein 1
IGF2 mRNA-binding protein 1
VICKZ family member 1
ZBP-1
coding region determinant-binding protein
insulin-like growth factor 2 mRNA binding protein 1 deltaN CRDBP
zipcode-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030585.1 RefSeqGene

    Range
    4974..63734
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001160423.2NP_001153895.1  insulin-like growth factor 2 mRNA-binding protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001153895.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC091133, AC105030, DA758608, DQ227344
    Consensus CDS
    CCDS54138.1
    UniProtKB/Swiss-Prot
    Q9NZI8
    Related
    ENSP00000389135.2, ENST00000431824.2
    Conserved Domains (5) summary
    cd12625
    Location:177
    RRM1_IGF2BP1; RNA recognition motif 1 (RRM1) found in vertebrate insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1)
    cd22493
    Location:135230
    KH-I_IGF2BP1_rpt2; second type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) and similar proteins
    cd22496
    Location:265340
    KH-I_IGF2BP1_rpt3; third type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) and similar proteins
    cd22499
    Location:348423
    KH-I_IGF2BP1_rpt4; fourth type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) and similar proteins
    cl17169
    Location:81135
    RRM_SF; RNA recognition motif (RRM) superfamily
  2. NM_006546.4NP_006537.3  insulin-like growth factor 2 mRNA-binding protein 1 isoform 1

    See identical proteins and their annotated locations for NP_006537.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC091133, AC105030, AF198254, AK074915, BP238821
    Consensus CDS
    CCDS11543.1
    UniProtKB/Swiss-Prot
    C9JT33, Q9NZI8
    Related
    ENSP00000290341.3, ENST00000290341.8
    Conserved Domains (6) summary
    cd12625
    Location:177
    RRM1_IGF2BP1; RNA recognition motif 1 (RRM1) found in vertebrate insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1)
    cd12628
    Location:81156
    RRM2_IGF2BP1; RNA recognition motif 2 (RRM2) found in vertebrate insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1)
    cd22490
    Location:197272
    KH-I_IGF2BP1_rpt1; first type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) and similar proteins
    cd22493
    Location:273369
    KH-I_IGF2BP1_rpt2; second type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) and similar proteins
    cd22496
    Location:404479
    KH-I_IGF2BP1_rpt3; third type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) and similar proteins
    cd22499
    Location:487562
    KH-I_IGF2BP1_rpt4; fourth type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    48996558..49056145
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047435139.1XP_047291095.1  insulin-like growth factor 2 mRNA-binding protein 1 isoform X1

    UniProtKB/Swiss-Prot
    C9JT33, Q9NZI8
  2. XM_011524201.3XP_011522503.1  insulin-like growth factor 2 mRNA-binding protein 1 isoform X2

    See identical proteins and their annotated locations for XP_011522503.1

    Conserved Domains (6) summary
    cd12625
    Location:177
    RRM1_IGF2BP1; RNA recognition motif 1 (RRM1) found in vertebrate insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1)
    cd12628
    Location:81156
    RRM2_IGF2BP1; RNA recognition motif 2 (RRM2) found in vertebrate insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1)
    cd22490
    Location:197272
    KH-I_IGF2BP1_rpt1; first type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) and similar proteins
    cd22493
    Location:273369
    KH-I_IGF2BP1_rpt2; second type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) and similar proteins
    cd22496
    Location:403478
    KH-I_IGF2BP1_rpt3; third type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) and similar proteins
    cd22499
    Location:486561
    KH-I_IGF2BP1_rpt4; fourth type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) and similar proteins
  3. XM_017024022.2XP_016879511.1  insulin-like growth factor 2 mRNA-binding protein 1 isoform X3

    Conserved Domains (3) summary
    smart00322
    Location:275347
    KH; K homology RNA-binding domain
    smart00360
    Location:82151
    RRM; RNA recognition motif
    cd12625
    Location:177
    RRM1_IGF2BP1; RNA recognition motif 1 (RRM1) found in vertebrate insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1)
  4. XM_047435140.1XP_047291096.1  insulin-like growth factor 2 mRNA-binding protein 1 isoform X4

  5. XM_047435143.1XP_047291099.1  insulin-like growth factor 2 mRNA-binding protein 1 isoform X8

    UniProtKB/TrEMBL
    D3DTW3
  6. XM_005256955.4XP_005257012.2  insulin-like growth factor 2 mRNA-binding protein 1 isoform X5

    Conserved Domains (3) summary
    COG0724
    Location:57146
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd00105
    Location:267332
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd12628
    Location:69144
    RRM2_IGF2BP1; RNA recognition motif 2 in vertebrate insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1)
  7. XM_047435141.1XP_047291097.1  insulin-like growth factor 2 mRNA-binding protein 1 isoform X6

  8. XM_047435142.1XP_047291098.1  insulin-like growth factor 2 mRNA-binding protein 1 isoform X7

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    49859908..49919501
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054314727.1XP_054170702.1  insulin-like growth factor 2 mRNA-binding protein 1 isoform X1

    UniProtKB/Swiss-Prot
    C9JT33, Q9NZI8
  2. XM_054314729.1XP_054170704.1  insulin-like growth factor 2 mRNA-binding protein 1 isoform X2

  3. XM_054314728.1XP_054170703.1  insulin-like growth factor 2 mRNA-binding protein 1 isoform X2

  4. XM_054314730.1XP_054170705.1  insulin-like growth factor 2 mRNA-binding protein 1 isoform X3

  5. XM_054314731.1XP_054170706.1  insulin-like growth factor 2 mRNA-binding protein 1 isoform X4

  6. XM_054314732.1XP_054170707.1  insulin-like growth factor 2 mRNA-binding protein 1 isoform X5

  7. XM_054314733.1XP_054170708.1  insulin-like growth factor 2 mRNA-binding protein 1 isoform X5

  8. XM_054314734.1XP_054170709.1  insulin-like growth factor 2 mRNA-binding protein 1 isoform X6

  9. XM_054314736.1XP_054170711.1  insulin-like growth factor 2 mRNA-binding protein 1 isoform X7

  10. XM_054314737.1XP_054170712.1  insulin-like growth factor 2 mRNA-binding protein 1 isoform X8

    UniProtKB/TrEMBL
    D3DTW3
  11. XM_054314735.1XP_054170710.1  insulin-like growth factor 2 mRNA-binding protein 1 isoform X6