Format

Send to:

Choose Destination

GAS2L1 growth arrest specific 2 like 1 [ Homo sapiens (human) ]

Gene ID: 10634, updated on 9-Oct-2021

Summary

Official Symbol
GAS2L1provided by HGNC
Official Full Name
growth arrest specific 2 like 1provided by HGNC
Primary source
HGNC:HGNC:16955
See related
Ensembl:ENSG00000185340 MIM:602128
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GAR22
Summary
This gene encodes a member of the growth arrest-specific 2 protein family. This protein binds components of the cytoskeleton and may be involved in mediating interactions between microtubules and microfilaments. This protein localizes to the proximal end of mature centrioles and links centrosomes to both microtubules and actin. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 9. [provided by RefSeq, May 2018]
Expression
Broad expression in testis (RPKM 11.4), fat (RPKM 8.4) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See GAS2L1 in Genome Data Viewer
Location:
22q12.2
Exon count:
7
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (29306650..29312787)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (29703013..29708776)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene rhomboid domain containing 3 Neighboring gene EWS RNA binding protein 1 Neighboring gene RAS like family 10 member A Neighboring gene adaptor related protein complex 1 subunit beta 1 Neighboring gene small nucleolar RNA, C/D box 125

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef Genome-wide shRNA screening identifies GAS2L1, which is required for HIV-1 Nef-induced downregulation of CD4 in HeLa CD4+ cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC17243

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cytoskeletal anchor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables thyroid hormone receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with actin filament IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with microtubule plus-end IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with microtubule plus-end IMP
Inferred from Mutant Phenotype
more info
PubMed 
colocalizes_with stress fiber IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
GAS2-like protein 1
Names
GAS2-related protein on chromosome 22
epididymis secretory sperm binding protein
growth arrest-specific protein 2-like 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032959.1 RefSeqGene

    Range
    5001..10781
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001278730.2NP_001265659.1  GAS2-like protein 1 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate splice site in the terminal exon compared to variant 1. The encoded isoform (c) is shorter than isoform a.
    Source sequence(s)
    AC002059, AK225484
    Consensus CDS
    CCDS63438.1
    UniProtKB/Swiss-Prot
    Q99501
    Related
    ENSP00000383995.3, ENST00000406549.7
    Conserved Domains (2) summary
    smart00243
    Location:206278
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    cd00014
    Location:29148
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
  2. NM_001362985.3NP_001349914.1  GAS2-like protein 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 5 encode isoform a.
    Source sequence(s)
    AC002059, KF459717
    Consensus CDS
    CCDS74840.1
    Related
    ENSP00000478908.1, ENST00000616432.4
    Conserved Domains (3) summary
    PHA03247
    Location:283662
    PHA03247; large tegument protein UL36; Provisional
    pfam02187
    Location:208276
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    cd21268
    Location:18152
    CH_GAS2L1_2; calponin homology (CH) domain found in GAS2-like protein 1 (GAS2L1), GAS2L2, and similar proteins
  3. NM_001395196.1NP_001382125.1  GAS2-like protein 1

    Status: REVIEWED

    Source sequence(s)
    AC002059, KF459717
    Conserved Domains (3) summary
    PHA03247
    Location:283662
    PHA03247; large tegument protein UL36; Provisional
    pfam02187
    Location:208276
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    cd21268
    Location:18152
    CH_GAS2L1_2; calponin homology (CH) domain found in GAS2-like protein 1 (GAS2L1), GAS2L2, and similar proteins
  4. NM_001395197.1NP_001382126.1  GAS2-like protein 1

    Status: REVIEWED

    Source sequence(s)
    AC002059, KF459717
    Conserved Domains (3) summary
    PHA03247
    Location:283662
    PHA03247; large tegument protein UL36; Provisional
    pfam02187
    Location:208276
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    cd21268
    Location:18152
    CH_GAS2L1_2; calponin homology (CH) domain found in GAS2-like protein 1 (GAS2L1), GAS2L2, and similar proteins
  5. NM_006478.5NP_006469.2  GAS2-like protein 1 isoform a

    See identical proteins and their annotated locations for NP_006469.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform (a). Variants 1, 2 and 5 encode isoform a.
    Source sequence(s)
    AC002059, BC011047
    Consensus CDS
    CCDS74840.1
    UniProtKB/Swiss-Prot
    Q99501
    UniProtKB/TrEMBL
    A0A5E8
    Related
    ENSP00000478343.1, ENST00000621062.4
    Conserved Domains (3) summary
    PHA03247
    Location:283662
    PHA03247; large tegument protein UL36; Provisional
    pfam02187
    Location:208276
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    cd21268
    Location:18152
    CH_GAS2L1_2; calponin homology (CH) domain found in GAS2-like protein 1 (GAS2L1), GAS2L2, and similar proteins
  6. NM_152236.3NP_689422.1  GAS2-like protein 1 isoform a

    See identical proteins and their annotated locations for NP_689422.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 5 encode isoform a.
    Source sequence(s)
    AC002059, AK093386
    Consensus CDS
    CCDS74840.1
    UniProtKB/Swiss-Prot
    Q99501
    UniProtKB/TrEMBL
    A0A5E8
    Related
    ENSP00000479551.1, ENST00000611648.2
    Conserved Domains (3) summary
    PHA03247
    Location:283662
    PHA03247; large tegument protein UL36; Provisional
    pfam02187
    Location:208276
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    cd21268
    Location:18152
    CH_GAS2L1_2; calponin homology (CH) domain found in GAS2-like protein 1 (GAS2L1), GAS2L2, and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    29306650..29312787
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011529825.1XP_011528127.1  GAS2-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011528127.1

    UniProtKB/Swiss-Prot
    Q99501
    UniProtKB/TrEMBL
    A0A5E8
    Conserved Domains (3) summary
    PHA03247
    Location:283662
    PHA03247; large tegument protein UL36; Provisional
    pfam02187
    Location:208276
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    cd21268
    Location:18152
    CH_GAS2L1_2; calponin homology (CH) domain found in GAS2-like protein 1 (GAS2L1), GAS2L2, and similar proteins
  2. XM_017028533.1XP_016884022.1  GAS2-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q99501
    UniProtKB/TrEMBL
    A0A5E8
    Related
    ENSP00000481012.1, ENST00000618518.3
    Conserved Domains (3) summary
    PHA03247
    Location:283662
    PHA03247; large tegument protein UL36; Provisional
    pfam02187
    Location:208276
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    cd21268
    Location:18152
    CH_GAS2L1_2; calponin homology (CH) domain found in GAS2-like protein 1 (GAS2L1), GAS2L2, and similar proteins

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_152237.1: Suppressed sequence

    Description
    NM_152237.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Support Center