U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

TXNIP thioredoxin interacting protein [ Homo sapiens (human) ]

Gene ID: 10628, updated on 6-Nov-2022

Summary

Official Symbol
TXNIPprovided by HGNC
Official Full Name
thioredoxin interacting proteinprovided by HGNC
Primary source
HGNC:HGNC:16952
See related
Ensembl:ENSG00000265972 MIM:606599; AllianceGenome:HGNC:16952
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
THIF; VDUP1; ARRDC6; HHCPA78; EST01027
Summary
This gene encodes a thioredoxin-binding protein that is a member of the alpha arrestin protein family. Thioredoxin is a thiol-oxidoreductase that is a major regulator of cellular redox signaling which protects cells from oxidative stress. This protein inhibits the antioxidative function of thioredoxin resulting in the accumulation of reactive oxygen species and cellular stress. This protein also functions as a regulator of cellular metabolism and of endoplasmic reticulum (ER) stress. This protein may also function as a tumor suppressor. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Expression
Ubiquitous expression in fat (RPKM 1044.5), spleen (RPKM 514.7) and 23 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See TXNIP in Genome Data Viewer
Location:
1q21.1
Exon count:
8
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (145992435..145996579, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (145109270..145113414, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (145438490..145442635)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RNA polymerase III subunit GL Neighboring gene Sharpr-MPRA regulatory region 4010 Neighboring gene ankyrin repeat domain 34A Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:145455010-145456209 Neighboring gene hemojuvelin BMP co-receptor Neighboring gene tRNA-Glu (anticodon CTC) 1-1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr HIV-1 Vpr upregulates the gene expression of TXNIP in human monocyte-derived dendritic cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables enzyme inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to tumor cell IDA
Inferred from Direct Assay
more info
PubMed 
involved_in keratinocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cell division IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in platelet-derived growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in protein import into nucleus IEA
Inferred from Electronic Annotation
more info
 
involved_in protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in response to calcium ion IEA
Inferred from Electronic Annotation
more info
 
involved_in response to estradiol IEA
Inferred from Electronic Annotation
more info
 
involved_in response to glucose IEA
Inferred from Electronic Annotation
more info
 
involved_in response to hydrogen peroxide IEA
Inferred from Electronic Annotation
more info
 
involved_in response to mechanical stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in response to progesterone IEA
Inferred from Electronic Annotation
more info
 
involved_in response to xenobiotic stimulus IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in mitochondrial intermembrane space IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
thioredoxin-interacting protein
Names
thioredoxin binding protein 2
upregulated by 1,25-dihydroxyvitamin D-3
vitamin D3 up-regulated protein 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001313972.2NP_001300901.1  thioredoxin-interacting protein isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate 5' most exon which results in the use of an alternate start codon compared to variant 1. The encoded isoform (2) has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC243547, AK304670, BQ030003
    Consensus CDS
    CCDS81368.1
    UniProtKB/Swiss-Prot
    Q9H3M7
    Related
    ENSP00000396322.2, ENST00000425134.2
    Conserved Domains (2) summary
    pfam02752
    Location:119243
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    cl22903
    Location:2797
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain
  2. NM_006472.6NP_006463.3  thioredoxin-interacting protein isoform 1

    See identical proteins and their annotated locations for NP_006463.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC243547, BC093704, BQ030003
    Consensus CDS
    CCDS72876.1
    UniProtKB/Swiss-Prot
    Q9BXG9, Q9H3M7
    UniProtKB/TrEMBL
    A0A024R4B7
    Related
    ENSP00000462521.1, ENST00000582401.6
    Conserved Domains (2) summary
    smart01017
    Location:175298
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    cl22903
    Location:10152
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    145992435..145996579 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    145109270..145113414 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)