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Txnip thioredoxin interacting protein [ Mus musculus (house mouse) ]

Gene ID: 56338, updated on 24-Jan-2023

Summary

Official Symbol
Txnipprovided by MGI
Official Full Name
thioredoxin interacting proteinprovided by MGI
Primary source
MGI:MGI:1889549
See related
Ensembl:ENSMUSG00000038393 AllianceGenome:MGI:1889549
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
THIF; Tbp-2; VDUP1; Hyplip1; 1200008J08Rik
Summary
Enables enzyme inhibitor activity. Acts upstream of or within several processes, including negative regulation of transcription by RNA polymerase II; platelet-derived growth factor receptor signaling pathway; and protein import into nucleus. Located in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Used to study Reye syndrome and hepatocellular carcinoma. Orthologous to human TXNIP (thioredoxin interacting protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in subcutaneous fat pad adult (RPKM 279.2), lung adult (RPKM 241.9) and 24 other tissues See more
Orthologs
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Genomic context

See Txnip in Genome Data Viewer
Location:
3 F2.1; 3 41.93 cM
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (96465273..96469173)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (96557957..96561857)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40100 Neighboring gene hemojuvelin BMP co-receptor Neighboring gene predicted gene 15441 Neighboring gene polymerase (RNA) III (DNA directed) polypeptide G like Neighboring gene ankyrin repeat domain 34A Neighboring gene predicted gene, 52628

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in mitochondrial intermembrane space ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
thioredoxin-interacting protein
Names
hyperlipidemia 1
thioredoxin binding protein-2
upregulated by 1,25-dihydroxyvitamin D-3
vitamin D3 up-regulated protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009935.2NP_001009935.1  thioredoxin-interacting protein isoform 1

    See identical proteins and their annotated locations for NP_001009935.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC122037
    Consensus CDS
    CCDS38555.1
    UniProtKB/Swiss-Prot
    Q8BG60, Q9R115
    Related
    ENSMUSP00000102710.3, ENSMUST00000074519.13
    Conserved Domains (2) summary
    pfam02752
    Location:175299
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    cl22903
    Location:10153
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain
  2. NM_023719.2NP_076208.2  thioredoxin-interacting protein isoform 2

    See identical proteins and their annotated locations for NP_076208.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
    Source sequence(s)
    AK089403, AK171456
    Consensus CDS
    CCDS17640.1
    UniProtKB/Swiss-Prot
    Q8BG60
    Related
    ENSMUSP00000041467.8, ENSMUST00000049093.8
    Conserved Domains (2) summary
    pfam02752
    Location:174298
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    cl22903
    Location:10152
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    96465273..96469173
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)