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TRIM16 tripartite motif containing 16 [ Homo sapiens (human) ]

Gene ID: 10626, updated on 11-Nov-2018

Summary

Official Symbol
TRIM16provided by HGNC
Official Full Name
tripartite motif containing 16provided by HGNC
Primary source
HGNC:HGNC:17241
See related
Ensembl:ENSG00000221926 MIM:609505; Vega:OTTHUMG00000059067
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EBBP
Summary
The protein encoded by this gene is a tripartite motif (TRIM) family member that contains two B box domains and a coiled-coiled region that are characteristic of the B box zinc finger protein family. While it lacks a RING domain found in other TRIM proteins, the encoded protein can homodimerize or heterodimerize with other TRIM proteins and has E3 ubiquitin ligase activity. This gene is also a tumor suppressor and is involved in secretory autophagy. [provided by RefSeq, Jan 2017]
Expression
Broad expression in esophagus (RPKM 47.9), placenta (RPKM 17.3) and 19 other tissues See more
Orthologs

Genomic context

See TRIM16 in Genome Data Viewer
Location:
17p12
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (15627966..15684311, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (15531277..15587625, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene TVP23C-CDRT4 readthrough Neighboring gene trans-golgi network vesicle protein 23 homolog C Neighboring gene peptidylprolyl isomerase A pseudogene 53 Neighboring gene proximal CMT1A-REP Neighboring gene CMT1A duplicated region transcript 1 Neighboring gene zinc finger protein 29, pseudogene Neighboring gene zinc finger protein 286A Neighboring gene ubiquitin conjugating enzyme E2 S pseudogene 1 Neighboring gene uncharacterized LOC105371560 Neighboring gene TBC1 domain family member 26

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: CDRT1

Homology

Clone Names

  • DKFZp434O1826

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
NACHT domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
interleukin-1 binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
PML body IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
tripartite motif-containing protein 16
Names
E3 ubiquitin-protein ligase TRIM16
estrogen-responsive B box protein
NP_001335048.1
NP_001335049.1
NP_001335050.1
NP_001335051.1
NP_001335053.1
NP_001335054.1
NP_001335055.1
NP_006461.3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001348119.1NP_001335048.1  tripartite motif-containing protein 16 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1, 2, and 3 all encode the same isoform (a).
    Source sequence(s)
    AC005324
    Consensus CDS
    CCDS11171.1
    UniProtKB/Swiss-Prot
    O95361
    Related
    ENSP00000497185.1, ENST00000649191.1
    Conserved Domains (2) summary
    cd12890
    Location:365546
    SPRY_PRY_TRIM16; PRY/SPRY domain in tripartite motif-containing protein 16 (TRIM16)
    cl25633
    Location:164283
    HlyD; HlyD membrane-fusion protein of T1SS
  2. NM_001348120.1NP_001335049.1  tripartite motif-containing protein 16 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), as well as variants 1 and 3, encodes isoform a.
    Source sequence(s)
    AC005324
    Consensus CDS
    CCDS11171.1
    UniProtKB/Swiss-Prot
    O95361
    Conserved Domains (2) summary
    cd12890
    Location:365546
    SPRY_PRY_TRIM16; PRY/SPRY domain in tripartite motif-containing protein 16 (TRIM16)
    cl25633
    Location:164283
    HlyD; HlyD membrane-fusion protein of T1SS
  3. NM_001348121.1NP_001335050.1  tripartite motif-containing protein 16 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), as well as variant 5, encodes isoform b.
    Source sequence(s)
    AC005324
    Consensus CDS
    CCDS86579.1
    UniProtKB/TrEMBL
    B3KP96
    Conserved Domains (1) summary
    cd12890
    Location:235416
    SPRY_PRY_TRIM16; PRY/SPRY domain in tripartite motif-containing protein 16 (TRIM16)
  4. NM_001348122.1NP_001335051.1  tripartite motif-containing protein 16 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), as well as variant 4, encodes isoform b.
    Source sequence(s)
    AC005324
    Consensus CDS
    CCDS86579.1
    UniProtKB/TrEMBL
    B3KP96
    Related
    ENSP00000399918.2, ENST00000416464.6
    Conserved Domains (1) summary
    cd12890
    Location:235416
    SPRY_PRY_TRIM16; PRY/SPRY domain in tripartite motif-containing protein 16 (TRIM16)
  5. NM_001348124.1NP_001335053.1  tripartite motif-containing protein 16 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), as well as variant 7, encodes isoform c.
    Source sequence(s)
    AC005324
    Consensus CDS
    CCDS86578.1
    UniProtKB/Swiss-Prot
    O95361
    Related
    ENSP00000462903.1, ENST00000577886.5
    Conserved Domains (1) summary
    cd12890
    Location:149330
    SPRY_PRY_TRIM16; PRY/SPRY domain in tripartite motif-containing protein 16 (TRIM16)
  6. NM_001348125.1NP_001335054.1  tripartite motif-containing protein 16 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), as well as variant 6, encodes isoform c.
    Source sequence(s)
    AC005324
    Consensus CDS
    CCDS86578.1
    UniProtKB/Swiss-Prot
    O95361
    Conserved Domains (1) summary
    cd12890
    Location:149330
    SPRY_PRY_TRIM16; PRY/SPRY domain in tripartite motif-containing protein 16 (TRIM16)
  7. NM_001348126.1NP_001335055.1  tripartite motif-containing protein 16 isoform d

    Status: REVIEWED

    Source sequence(s)
    AC005324
    Conserved Domains (1) summary
    cd12890
    Location:203384
    SPRY_PRY_TRIM16; PRY/SPRY domain in tripartite motif-containing protein 16 (TRIM16)
  8. NM_006470.4NP_006461.3  tripartite motif-containing protein 16 isoform a

    See identical proteins and their annotated locations for NP_006461.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), as well as variants 1 and 2, encodes isoform a.
    Source sequence(s)
    AC005324, BC053514, DA709639
    Consensus CDS
    CCDS11171.1
    UniProtKB/Swiss-Prot
    O95361
    Related
    ENSP00000338989.7, ENST00000336708.11
    Conserved Domains (2) summary
    cd12890
    Location:365546
    SPRY_PRY_TRIM16; PRY/SPRY domain in tripartite motif-containing protein 16 (TRIM16)
    cl25633
    Location:164283
    HlyD; HlyD membrane-fusion protein of T1SS

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

    Range
    15627966..15684311 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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