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Trim16 tripartite motif-containing 16 [ Mus musculus (house mouse) ]

Gene ID: 94092, updated on 27-Feb-2024

Summary

Official Symbol
Trim16provided by MGI
Official Full Name
tripartite motif-containing 16provided by MGI
Primary source
MGI:MGI:2137356
See related
Ensembl:ENSMUSG00000047821 AllianceGenome:MGI:2137356
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EBBP; 9130006M08Rik
Summary
Predicted to enable DNA binding activity; NACHT domain binding activity; and interleukin-1 binding activity. Located in cytoplasm. Is expressed in genitourinary system. Orthologous to several human genes including TRIM16 (tripartite motif containing 16). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in colon adult (RPKM 13.4), lung adult (RPKM 10.4) and 19 other tissues See more
Orthologs
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Genomic context

See Trim16 in Genome Data Viewer
Location:
11 B2; 11 38.75 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (62711034..62733774)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (62820198..62842948)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 286 Neighboring gene zinc finger protein 286, opposite strand Neighboring gene predicted gene, 24151 Neighboring gene STARR-seq mESC enhancer starr_29718 Neighboring gene F-box and WD-40 domain protein 10 Neighboring gene STARR-seq mESC enhancer starr_29719 Neighboring gene STARR-positive B cell enhancer ABC_E1826 Neighboring gene trans-golgi network vesicle protein 23B

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables NACHT domain binding ISO
Inferred from Sequence Orthology
more info
 
enables interleukin-1 binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in PML body ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
tripartite motif-containing protein 16
Names
E3 ubiquitin-protein ligase TRIM16
estrogen-responsive B box protein
tripartite motif protein 16
NP_444399.2
XP_006534643.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053169.2NP_444399.2  tripartite motif-containing protein 16

    See identical proteins and their annotated locations for NP_444399.2

    Status: VALIDATED

    Source sequence(s)
    AK053139, AK087112, BB033733
    Consensus CDS
    CCDS24832.1
    UniProtKB/Swiss-Prot
    Q7TPY6, Q8C332, Q8C6V0, Q99PP9
    UniProtKB/TrEMBL
    Q5SVT2
    Related
    ENSMUSP00000055542.6, ENSMUST00000055006.12
    Conserved Domains (2) summary
    pfam00643
    Location:117157
    zf-B_box; B-box zinc finger
    cd12890
    Location:357538
    SPRY_PRY_TRIM16; PRY/SPRY domain in tripartite motif-containing protein 16 (TRIM16)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    62711034..62733774
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534580.5XP_006534643.1  tripartite motif-containing protein 16 isoform X1

    UniProtKB/Swiss-Prot
    Q7TPY6, Q8C332, Q8C6V0, Q99PP9
    Related
    ENSMUSP00000104343.2, ENSMUST00000108703.2
    Conserved Domains (4) summary
    pfam05483
    Location:87275
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    cd12890
    Location:270451
    SPRY_PRY_TRIM16; PRY/SPRY domain in tripartite motif-containing protein 16 (TRIM16)
    cd19769
    Location:3378
    Bbox2_TRIM16-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM16, TRIM29, TRIM47 and similar proteins
    cl00034
    Location:126
    Bbox_SF; B-box-type zinc finger superfamily