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HEXIM1 HEXIM P-TEFb complex subunit 1 [ Homo sapiens (human) ]

Gene ID: 10614, updated on 10-Oct-2019

Summary

Official Symbol
HEXIM1provided by HGNC
Official Full Name
HEXIM P-TEFb complex subunit 1provided by HGNC
Primary source
HGNC:HGNC:24953
See related
Ensembl:ENSG00000186834 MIM:607328
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CLP1; EDG1; HIS1; MAQ1
Summary
Expression of this gene is induced by hexamethylene-bis-acetamide in vascular smooth muscle cells. This gene has no introns. [provided by RefSeq, Jul 2008]
Orthologs

Genomic context

See HEXIM1 in Genome Data Viewer
Location:
17q21.31
Exon count:
1
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (45148475..45152099)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (43224684..43229468)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene phospholipase C delta 3 Neighboring gene microRNA 6784 Neighboring gene acyl-CoA binding domain containing 4 Neighboring gene uncharacterized LOC112268203 Neighboring gene HEXIM P-TEFb complex subunit 2 Neighboring gene uncharacterized LOC105371795

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection increases HEXIM1 expression in monocyte derived macrophages PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat CDK9-CycT1-AFF1 is stimulated by HIV-1 Tat and transferred as a single complex unit to BRD4 upon stress-induced disruption of AFF1-containing 7SK snRNP (HEXIM1, MEPCE, LARP7, 7SK RNA, CDK9, CycT1, and AFF1) PubMed
tat AFF1 enhances the affinity of HIV-1 Tat for CycT1, which competitively dissociates HEXIM1 and is responsible for AFF1's promotion of Tat's extraction of CDK9/CycT1 from 7SK snRNP PubMed
tat HIV-1 Tat displaces HEXIM1 from Cyclin T1 in the context of the native 7SK snRNP by interacting with the Cyclin T1-binding domain (amino acid 255-359) of HEXIM1 PubMed
tat CDK11 depletion reduces protein expression of CDK9 and HEXIM1 and Tat transactivation of HIV-1 provirus PubMed
tat A La-related protein, LARP7, is associated with P-TEFb, HEXIM1/2, MEPCE, and 7SK RNA in a large stable complex form. Knockdown of LARP7 decreases the steady-state level of 7SK, but increases free P-TEFb and enhances Tat-mediated transcription PubMed
tat HIV-1 Tat-mediated release of P-TEFb from the 7SK sn RNP results in a conformational change in 7SK RNA and release of HEXIM1 from the complex PubMed
tat TAR binds Tat and P-TEFb as it emerges on the nascent transcript, competitively displacing the inhibitory 7SK snRNP (HEXIM1 and LARP7) and activating the P-TEFb kinase PubMed
tat HIV-1 Tat competes with HEXIM1 for binding to 7SK RNA and inhibits the formation of the P-TEFb-HEXIM1-7SK complex. Tat binds to nucleotides 10-48 of 7SK RNA PubMed
tat HIV-1 Tat directly interacts with human 7SK snRNA in living cells. The 5' hairpin of human 7SK snRNA carries a conserved Tat-binding element and two HEXIM1-binding sites. Tat competes with HEXIM1 for 7SK snRNA binding PubMed
tat HIV-1 Tat transactivation is effectively inhibited by co-expression of HEXIM1 or its paralog HEXIM2; HEXIM1 expression specifically represses transcription mediated by the direct activation of P-TEFb through Tat recruitment of CycT1 PubMed
tat MAQ1 complexes with 7SK RNA and cyclin T1 and competes with the binding of Tat to cyclin T1, suggesting the TAR RNA/Tat lentivirus system has evolved to subvert the cellular 7SK RNA/MAQ1 system PubMed
tat HIV-1 Tat competes with Hexim1 (residues 255-359) for cyclin T1 binding, thus releasing P-TEFb from the inactive complex to stimulate the transcription of HIV-1 gene expression PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13562

Gene Ontology Provided by GOA

Function Evidence Code Pubs
7SK snRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
7SK snRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
cyclin-dependent protein serine/threonine kinase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cyclin-dependent protein serine/threonine kinase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
snRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein HEXIM1
Names
HMBA-inducible
cardiac lineage protein 1
estrogen down-regulated gene 1 protein
hexamethylene bis-acetamide inducible 1
hexamethylene bis-acetamide-inducible protein 1
hexamethylene bisacetamide inducible 1
hexamethylene bisacetamide-inducible protein
hexamethylene-bis-acetamide-inducible transcript 1
hexamthylene bis-acetamide inducible 1
menage a quatre 1
menage a quatre protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006460.3NP_006451.1  protein HEXIM1

    See identical proteins and their annotated locations for NP_006451.1

    Status: REVIEWED

    Source sequence(s)
    AC142472
    Consensus CDS
    CCDS11495.1
    UniProtKB/Swiss-Prot
    O94992
    Related
    ENSP00000328773.2, ENST00000332499.3
    Conserved Domains (2) summary
    TIGR04211
    Location:283351
    SH3_and_anchor; SH3 domain protein
    pfam15313
    Location:200298
    HEXIM; Hexamethylene bis-acetamide-inducible protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    45148475..45152099
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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