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Hexim1 hexamethylene bis-acetamide inducible 1 [ Mus musculus (house mouse) ]

Gene ID: 192231, updated on 18-Apr-2024

Summary

Official Symbol
Hexim1provided by MGI
Official Full Name
hexamethylene bis-acetamide inducible 1provided by MGI
Primary source
MGI:MGI:2385923
See related
Ensembl:ENSMUSG00000048878 AllianceGenome:MGI:2385923
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Clp1; HIS1; CLP-1; 7330426E13Rik
Summary
Predicted to enable several functions, including 7SK snRNA binding activity; P-TEFb complex binding activity; and cyclin-dependent protein serine/threonine kinase inhibitor activity. Acts upstream of or within heart development and negative regulation of transcription, DNA-templated. Located in nucleus. Is expressed in several structures, including branchial arch; embryo mesenchyme; heart and pericardium; hindgut dorsal mesentery; and sensory organ. Orthologous to human HEXIM1 (HEXIM P-TEFb complex subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Note: Hexim1 (Gene ID: 192231) and Clp1 (Gene ID: 98985) loci share the Clp1 symbol/alias in common. [08 Feb 2019]
Orthologs
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Genomic context

Location:
11 E1; 11 66.71 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (103007151..103010551)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (103116325..103119725)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene phospholipase C, delta 3 Neighboring gene STARR-seq mESC enhancer starr_30831 Neighboring gene STARR-positive B cell enhancer ABC_E204 Neighboring gene acyl-Coenzyme A binding domain containing 4 Neighboring gene STARR-positive B cell enhancer ABC_E4004 Neighboring gene STARR-positive B cell enhancer ABC_E738 Neighboring gene hexamethylene bis-acetamide inducible 2 Neighboring gene STARR-positive B cell enhancer ABC_E379 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:103003747-103004003 Neighboring gene STARR-positive B cell enhancer ABC_E10717 Neighboring gene predicted gene, 51919

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 7SK snRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables 7SK snRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables P-TEFb complex binding ISO
Inferred from Sequence Orthology
more info
 
enables cyclin-dependent protein serine/threonine kinase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cyclin-dependent protein serine/threonine kinase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables snRNA binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of 7SK snRNP ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protein HEXIM1
Names
cardiac lineage protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138753.2NP_620092.1  protein HEXIM1

    See identical proteins and their annotated locations for NP_620092.1

    Status: VALIDATED

    Source sequence(s)
    AL731805
    Consensus CDS
    CCDS25513.1
    UniProtKB/Swiss-Prot
    Q8R409
    Related
    ENSMUSP00000057339.6, ENSMUST00000053063.7
    Conserved Domains (1) summary
    pfam15313
    Location:163295
    HEXIM; Hexamethylene bis-acetamide-inducible protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    103007151..103010551
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)