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Mtbp Mdm2, transformed 3T3 cell double minute p53 binding protein [ Mus musculus (house mouse) ]

Gene ID: 105837, updated on 21-Jan-2023

Summary

Official Symbol
Mtbpprovided by MGI
Official Full Name
Mdm2, transformed 3T3 cell double minute p53 binding proteinprovided by MGI
Primary source
MGI:MGI:2146005
See related
Ensembl:ENSMUSG00000022369 AllianceGenome:MGI:2146005
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MDM2BP
Summary
Acts upstream of or within negative regulation of cell population proliferation; negative regulation of mitotic nuclear division; and traversing start control point of mitotic cell cycle. Located in kinetochore. Is expressed in cerebellum; midbrain ventricular layer; olfactory cortex ventricular layer; and telencephalon ventricular layer. Orthologous to human MTBP (MDM2 binding protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 5.1), limb E14.5 (RPKM 4.4) and 21 other tissues See more
Orthologs
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Genomic context

See Mtbp in Genome Data Viewer
Location:
15; 15 D1
Exon count:
26
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (55420800..55489819)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (55557404..55626423)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene collagen, type XIV, alpha 1 Neighboring gene predicted gene, 18787 Neighboring gene mitochondrial ribosomal protein L13 Neighboring gene syntrophin, basic 1 Neighboring gene predicted gene, 46516

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in chromatin ISO
Inferred from Sequence Orthology
more info
 
is_active_in kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
mdm2-binding protein
Names
mMTBP

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168250.1NP_001161722.1  mdm2-binding protein isoform 2

    See identical proteins and their annotated locations for NP_001161722.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an alternate exon in the coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC123682, AK133855, BB615361
    Consensus CDS
    CCDS49609.1
    UniProtKB/Swiss-Prot
    Q8BJS8
    Related
    ENSMUSP00000129396.2, ENSMUST00000170046.8
    Conserved Domains (2) summary
    pfam14918
    Location:1270
    MTBP_N; MDM2-binding
    pfam14919
    Location:287622
    MTBP_mid; MDM2-binding
  2. NM_001416109.1NP_001403038.1  mdm2-binding protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC123682
  3. NM_001416110.1NP_001403039.1  mdm2-binding protein isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC123682
  4. NM_001416111.1NP_001403040.1  mdm2-binding protein isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC123682
  5. NM_001416112.1NP_001403041.1  mdm2-binding protein isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC123682
  6. NM_001416113.1NP_001403042.1  mdm2-binding protein isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC123682
  7. NM_134092.4NP_598853.3  mdm2-binding protein isoform 1

    See identical proteins and their annotated locations for NP_598853.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC123682
    Consensus CDS
    CCDS27478.1
    UniProtKB/Swiss-Prot
    Q8BJS8, Q9ER61
    Related
    ENSMUSP00000022998.8, ENSMUST00000022998.14
    Conserved Domains (3) summary
    pfam14918
    Location:1270
    MTBP_N; MDM2-binding
    pfam14919
    Location:287626
    MTBP_mid; MDM2-binding
    pfam14920
    Location:630884
    MTBP_C; MDM2-binding

RNA

  1. NR_183253.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC123682

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    55420800..55489819
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011245394.2XP_011243696.1  mdm2-binding protein isoform X1

    Conserved Domains (2) summary
    pfam14918
    Location:1270
    MTBP_N; MDM2-binding
    pfam14919
    Location:287622
    MTBP_mid; MDM2-binding
  2. XM_006520250.3XP_006520313.1  mdm2-binding protein isoform X2

    Conserved Domains (2) summary
    pfam14919
    Location:1296
    MTBP_mid; MDM2-binding
    pfam14920
    Location:300554
    MTBP_C; MDM2-binding
  3. XM_017316360.3XP_017171849.1  mdm2-binding protein isoform X2

    Conserved Domains (2) summary
    pfam14919
    Location:1296
    MTBP_mid; MDM2-binding
    pfam14920
    Location:300554
    MTBP_C; MDM2-binding
  4. XM_017316361.3XP_017171850.1  mdm2-binding protein isoform X3

    Related
    ENSMUSP00000128615.2, ENSMUST00000169667.2
    Conserved Domains (2) summary
    pfam14919
    Location:2225
    MTBP_mid; MDM2-binding
    pfam14920
    Location:229483
    MTBP_C; MDM2-binding

RNA

  1. XR_004938781.1 RNA Sequence

  2. XR_383964.2 RNA Sequence

  3. XR_875211.2 RNA Sequence