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MTBP MDM2 binding protein [ Homo sapiens (human) ]

Gene ID: 27085, updated on 17-Jun-2019

Summary

Official Symbol
MTBPprovided by HGNC
Official Full Name
MDM2 binding proteinprovided by HGNC
Primary source
HGNC:HGNC:7417
See related
Ensembl:ENSG00000172167 MIM:605927
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MDM2BP
Summary
This gene encodes a protein that interacts with the oncoprotein mouse double minute 2. The encoded protein regulates progression through the cell cycle and may be involved in tumor formation. [provided by RefSeq, Aug 2012]
Expression
Broad expression in testis (RPKM 2.1), lymph node (RPKM 1.4) and 24 other tissues See more
Orthologs

Genomic context

See MTBP in Genome Data Viewer
Location:
8q24.12
Exon count:
25
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (120445401..120523636)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (121457638..121535875)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene collagen type XIV alpha 1 chain Neighboring gene mitochondrial ribosomal protein L13 Neighboring gene syntrophin beta 1 Neighboring gene non-SMC condensin I complex subunit G pseudogene 1 Neighboring gene uncharacterized LOC101927543

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Epidemiological and genome-wide association study of gastritis or gastric ulcer in korean populations.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
cell cycle arrest IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of mitotic nuclear division IEA
Inferred from Electronic Annotation
more info
 
protein localization to kinetochore IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
traversing start control point of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
chromatin IDA
Inferred from Direct Assay
more info
PubMed 
kinetochore IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
mdm2-binding protein
Names
MDM2 (mouse double minute 2)-binding protein, 104kD
Mdm2, transformed 3T3 cell double minute 2, p53 binding protein binding protein, 104kDa

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033151.1 RefSeqGene

    Range
    5001..83238
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_022045.5NP_071328.2  mdm2-binding protein

    See identical proteins and their annotated locations for NP_071328.2

    Status: REVIEWED

    Source sequence(s)
    AC105142, AC107877, BC013136
    Consensus CDS
    CCDS6333.1
    UniProtKB/Swiss-Prot
    Q96DY7
    Related
    ENSP00000303398.1, ENST00000305949.6
    Conserved Domains (3) summary
    pfam14918
    Location:1270
    MTBP_N; MDM2-binding
    pfam14919
    Location:294632
    MTBP_mid; MDM2-binding
    pfam14920
    Location:636894
    MTBP_C; MDM2-binding

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    120445401..120523636
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011516962.2XP_011515264.1  mdm2-binding protein isoform X1

    Conserved Domains (3) summary
    pfam14918
    Location:1270
    MTBP_N; MDM2-binding
    pfam14919
    Location:294632
    MTBP_mid; MDM2-binding
    pfam14920
    Location:636660
    MTBP_C; MDM2-binding
  2. XM_011516963.2XP_011515265.1  mdm2-binding protein isoform X2

    Conserved Domains (2) summary
    pfam14918
    Location:1270
    MTBP_N; MDM2-binding
    pfam14919
    Location:294483
    MTBP_mid; MDM2-binding

RNA

  1. XR_928318.2 RNA Sequence

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