Conserved Protein Domain Family
MTBP_C
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pfam14920: MTBP_C (this model, PSSM-Id:291581 is obsolete and has been replaced by 464376)
MDM2-binding
MTBP, or MDM2-binding protein, binds to MDM2. The MDM2 protein, through its interaction with p53, plays an important role in the regulation of the G1 checkpoint of the cell cycle. MTBP promotes MDM2-mediated ubiquitination and degradation of p53 and also MDM2 stabilization in an MDM2 RING finger-dependent manner. MTBP differentially regulates the E3 ubiquitin ligase activity of MDM2 towards two of its most critical targets (itself and p53) and in doing so significantly contributes to MDM2-dependent p53 homeostasis in unstressed cells. MTBP inhibits cancer cell migration by interacting with a protein involved in cell motility. This motility protein is alpha-actinin-4 (ACTN4). It is unclear which regions of MTBP interact with which binding-partner. See PF14918, PF14919.
Links
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Statistics
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PSSM-Id: 291581
Aligned: 18 rows
Threshold Bit Score: 266.204
Created: 16-Jul-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q0P4G8       604 PKLTPKKLKGLPFEKAAECHYHGLEYCLDNRKALDRDVAFSELQSRLIRYETQTTCTRECCPVPFALSPLPSPAVLSEPG 683 western clawed ...
XP_005019098 594 PELTPRKLRGLPFEKAAGCHYHGLEYCLDNRKALERDVGYAELQTRLIRYETQTTCTKECCPVPVVLSPLPSPAVLSEPG 673 mallard
XP_005662935 636 PELSPRKLRGLPFEKASVCHYHGIEYCLDDRKALERDGGFSELQSRLIRYETQTTCTRESFPAPAVLSPLPSPAVLSEPG 715 pig
XP_008115123 620 PELSPRTLRSLPFEKAADCRYHGLEYCLDNRRALERDVGFAELQTRLIRYETQTTCTKECCPVPCILSPLPSPAVLSEPG 699 green anole
XP_005994624 607 rNLTPRKVRHLPFKEAATCHYHGLEYCLDDRKALERDMAFAKLQSRLVRYETQTTCSRECCPIPYALSPLPSPAVLSEPG 686 coelacanth
XP_003430578 244 PELTPRKLRVLPFEKAAVCHYHGLEYCLDGRKALERDGGFSELQSRLIRYETQTTCAKECIPLPWVLSPLPSPVVLSEAG 323 platypus
XP_006636138 534 cDLTPRKVQHLPFNKAANSHYHGIEFCLDDRNSLDRDKAFGKLQSRLIRYETHTTCSKEPCPVPFALSPAPSPAVLSEPG 613 spotted gar
XP_005450583 574 qDLSPRRISKLPFSKASASHYHGIEFCLDNQRSLDRDQAFVRLQSRLIRYETQTTCSKEPCALPFALSPAPSPAVMSEPG 653 Nile tilapia
XP_011603791 551 PDLSPGRVSLMPFTKASALHYHGLEFCLDEKRSLVQDQAFVKLQSRLIRYETQTTCSKEPSALPFALSPAPSPAVMSEPG 630 torafugu
XP_004077798 607 PDLSPGRVSQMPFSKASGSHYHGLEFCLDNQRSLDRDQVFARLQSRLIRYETQTTCSKEPCALPFALSPAPSPALISEPG 686 Japanese medaka

Q0P4G8       684 SVPDGESIQTELRGEPLLLKRRSRDLD--GLYASK--RLAKSGSSDSLVSLASEGSGHQ-PPTRATRLRPERAASS---- 754 western clawed ...
XP_005019098 674 SVPDGESLQSEFRTEASRLKRRSKDLD--CFYPKK--RLTKSESTDSLLSQASGGSGSH-STVVVTRKRSERSVSL---- 744 mallard
XP_005662935 716 SVPDGEALQSELRPEASRLKRRSKDLN--CLYPLK--RLAKSESSDSLLSQTSGSTKPHpPAVTSRRPRAERSLSV---- 787 pig
XP_008115123 700 SIPDGESLQREPQTEASRLKRRSKDLD--GLYPNK--RLVKSESTDSLMSQASISSRSC-PSRVVTKQCLETSVSL---- 770 green anole
XP_005994624 687 SIPDGETLQNELKTETGRFKRRSRDLD--GGCSSK--RLAKSESTESLLSQANGSGIHH-HSASTRSDRPQRSISA---- 757 coelacanth
XP_003430578 324 SVPDVETLQSEARTDIARQKRRSRDLD--GCYPNK--RLAKSESSDSLLSQASGSSAAA-ATRQFPEPELSLSLSV---- 394 platypus
XP_006636138 614 SVPEGEAFQLEQKGELSR---------------RK--RLPKSESSNSLLSHPGGSSGHR-AAARSLRDQPQRSVST---- 671 spotted gar
XP_005450583 654 SVPDGETL---LNNDVARLKRRSWEADivGGYPHK--RLAKSESSDSLCSQSSSSSGTH-PAIRSLRRQPSRSQSTssvn 727 Nile tilapia
XP_011603791 631 SVPDGETLE---NADVARLKRRSWDMDilSGCPQK--RLVKSESSDSLCSQSSGSSGTH-PAVRSLRRQPGRSKSStsss 704 torafugu
XP_004077798 687 SVPDGETL---LNSDVSRLKCRSWEAElaGGPTRRklRLVKSGSSDSFCSPSSNSSGVH-STVKTLQQQPSRSQST---- 758 Japanese medaka

Q0P4G8       755 ---------------TSAVQPPSAR----VQMAP----SVP---------AQSKQSTHPDLEQKESRSQKHNRMLKEVVS 802 western clawed ...
XP_005019098 745 ---------------TSVQLKQSGQ----LPKVTskvgSAS---------HRSATESQTSKPVKESRSQKHTRMLKEVVA 796 mallard
XP_005662935 788 ---------------TCPSISVLSSetpkVATKV----NSG---------QKSTHLSKTSRPAKESRSQKHTRILKEVVT 839 pig
XP_008115123 771 ---------------PSLAAKQPHHq--aIPKSR----AAS---------QRCGTEPGISRPTKESRSQKHTRMLKEVVA 820 green anole
XP_005994624 758 ---------------SASTKHSSGQsrklAAKTG----QES---------QRGTQKSETQQQKKESRSQKHTRMLKEIVA 809 coelacanth
XP_003430578 395 ---------------TNTSGPQPGS----ET--A----QPS---------HRSGQESETSRKTKESRSQKHTRMLKEVVA 440 platypus
XP_006636138 672 ---------------ASAPLKRSPS-----TGRE----CQS---------QGKTQGQATAQPTKESRSQKHVRMLKEVVA 718 spotted gar
XP_005450583 728 ss-------sssatrPTSGLATLAC----VDRPK----CQQ---------QKTHQGHSEDKPAKESRSQKHNRMLQEVVA 783 Nile tilapia
XP_011603791 705 fssstglssssstrqTASGGATLPS----SGKHK----PQQ---------QTTLNGEAEEKTAKESRSQKHNRMLLEVVA 767 torafugu
XP_004077798 759 ---------------SSSVCTPAGT----RHTAV----SVSapdglkvqqQRTSQRNFEDKRAKESRSQKHNRMLEEVVG 815 Japanese medaka

Q0P4G8       803 KTLQKYGIGVEHPCYAACNQRLFDISKFFLKDLKTSRGLLDEMKKAASNNAKQVI 857 western clawed frog
XP_005019098 797 KTLQKHGIPEDHKCFESCSQRLFEISKFYLKDLKTSRGLLDEMKKTANNNAKQVI 851 mallard
XP_005662935 840 ATLKKHRITEDHECFVPCSQRLFEISKFYLKDLKTSRGLFEEMKKTANNNVVQVI 894 pig
XP_008115123 821 KTLGNHGITEDHKCFETCSHRLFEISKFYLKDLKTSRGLFDEMKKAANSNVKQVI 875 green anole
XP_005994624 810 KTLKNHGIAEDHPCFAACSQRLFEISKFYLKDLKTSRGLHEEMKKAASSNVKQVI 864 coelacanth
XP_003430578 441 KTLKKHNMTEDHECFSACSQRLFEISKFYLKDLKTSRGLLEEMKKTANNNVKQVI 495 platypus
XP_006636138 719 KTLSHHGIREDHESFEACSQRLFEISKFYLKDLKTSRGLHEEMKKAANNNAKQVI 773 spotted gar
XP_005450583 784 KTLKHHGITAEHDCFEACSKRLFDISKFYLKDLKTSRGLHDEMRKAASSNVKQVI 838 Nile tilapia
XP_011603791 768 KTLKHHGIGVEHECFEACSKRLFDISKFYLKDLKTSRGLHEEMKKAAGSNVKQVI 822 torafugu
XP_004077798 816 KTLKHHGISVEHKCYEACSKRLFDISKFYLKDLKTSRGLYDEMKKAASSNVKQVI 870 Japanese medaka
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