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ARFGEF2 ADP ribosylation factor guanine nucleotide exchange factor 2 [ Homo sapiens (human) ]

Gene ID: 10564, updated on 4-Jul-2021

Summary

Official Symbol
ARFGEF2provided by HGNC
Official Full Name
ADP ribosylation factor guanine nucleotide exchange factor 2provided by HGNC
Primary source
HGNC:HGNC:15853
See related
Ensembl:ENSG00000124198 MIM:605371
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BIG2; PVNH2; dJ1164I10.1
Summary
ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP and is involved in Golgi transport. It contains a Sec7 domain, which may be responsible for its guanine-nucleotide exchange activity and also brefeldin A inhibition. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 19.9), adrenal (RPKM 14.6) and 25 other tissues See more
Orthologs
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Genomic context

See ARFGEF2 in Genome Data Viewer
Location:
20q13.13
Exon count:
39
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (48921711..49036693)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (47538248..47653230)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 Neighboring gene uncharacterized LOC105372648 Neighboring gene CSE1L antisense RNA 1 Neighboring gene synaptosome associated protein 23 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpu vpu HIV-1 Vpu is identified to have a physical interaction with ADP-ribosylation factor guanine nucleotide-exchange factor 2 (ARFGEF2; BIG2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ23723

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GABA receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase A regulatory subunit binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in asymmetric synapse ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in axonemal microtubule ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytoplasmic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendritic spine ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
located_in membrane HDA PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in microtubule organizing center IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in recycling endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in symmetric synapse ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in trans-Golgi network ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
brefeldin A-inhibited guanine nucleotide-exchange protein 2
Names
ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
brefeldin A-inhibited GEP 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011490.2 RefSeqGene

    Range
    4974..119956
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_006420.3NP_006411.2  brefeldin A-inhibited guanine nucleotide-exchange protein 2

    See identical proteins and their annotated locations for NP_006411.2

    Status: REVIEWED

    Source sequence(s)
    AB209397, AK074303, AL049537, AL121903, BC050449
    Consensus CDS
    CCDS13411.1
    UniProtKB/Swiss-Prot
    Q9Y6D5
    UniProtKB/TrEMBL
    Q59FR3, Q86TH5
    Related
    ENSP00000360985.4, ENST00000371917.5
    Conserved Domains (5) summary
    PLN03076
    Location:111711
    PLN03076; ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
    pfam01369
    Location:643827
    Sec7; Sec7 domain
    pfam09324
    Location:11671248
    DUF1981; Domain of unknown function (DUF1981)
    pfam12783
    Location:370524
    Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
    pfam16213
    Location:28198
    DCB; Dimerization and cyclophilin-binding domain of Mon2

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    48921711..49036693
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005260252.3XP_005260309.1  brefeldin A-inhibited guanine nucleotide-exchange protein 2 isoform X1

    Related
    ENSP00000504888.1, ENST00000679436.1
    Conserved Domains (5) summary
    PLN03076
    Location:111710
    PLN03076; ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
    pfam01369
    Location:642826
    Sec7; Sec7 domain
    pfam09324
    Location:11661247
    DUF1981; Domain of unknown function (DUF1981)
    pfam12783
    Location:369523
    Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
    pfam16213
    Location:28198
    DCB; Dimerization and cyclophilin-binding domain of Mon2
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