Arfgef2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Arfgef2provided by MGI
Official Full Name: ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)provided by MGI
Primary source: MGI:MGI:2139354
See related: Ensembl:ENSMUSG00000074582 AllianceGenome:MGI:2139354
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: BIG2; E230011G24Rik
Summary: Predicted to enable several functions, including GABA receptor binding activity; guanyl-nucleotide exchange factor activity; and protein kinase A regulatory subunit binding activity. Predicted to be involved in several processes, including Golgi to plasma membrane transport; positive regulation of tumor necrosis factor production; and receptor recycling. Predicted to act upstream of or within intracellular signal transduction. Predicted to be located in several cellular components, including Golgi apparatus; microtubule cytoskeleton; and recycling endosome. Is expressed in brown fat; central nervous system; duodenum; thymus; and trunk. Human ortholog(s) of this gene implicated in periventricular nodular heterotopia. Orthologous to human ARFGEF2 (ADP ribosylation factor guanine nucleotide exchange factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in adrenal adult (RPKM 9.9), lung adult (RPKM 8.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2; 2 H3

Exon count:: 39

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (166647371..166739972)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (166805451..166898052)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

coordinated interactions between actin (through FlnA) and vesicle trafficking (through Big2-Arf) direct the assembly and disassembly of membrane protein complexes required for neuronal migration and neuroependymal integrity.
Title: Filamin A regulates neuronal migration through brefeldin A-inhibited guanine exchange factor 2-dependent Arf1 activation.
an early acting GEF (GBF1) activates ARFs that mediate recruitment of late acting GEFs (BIG1/2) to coordinate coating events within the pre-Golgi/Golgi/TGN continuum.
Title: The Sec7 guanine nucleotide exchange factor GBF1 regulates membrane recruitment of BIG1 and BIG2 guanine nucleotide exchange factors to the trans-Golgi network (TGN).
Big2 inhibition promotes Filamin A phosphorylation, thereby disrupting cell intrinsic neuronal migration.
Title: Brefeldin A-inhibited guanine exchange factor 2 regulates filamin A phosphorylation and neuronal migration.
Results indicate that murine BIG2 is essential for early embryonic development.
Title: Early embryonic lethality in gene trap mice with disruption of the Arfgef2 gene.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1) 1 citation
Targeted (1) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW493672 (e-PCR)
- UniSTS:178774

AI463430 (e-PCR)
- UniSTS:159076

STS-R64296 (e-PCR)
- UniSTS:45429

Homology

Homologs of the Arfgef2 gene: The Arfgef2 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, S.pombe, A.thaliana, and frog.
Orthologs from Annotation Pipeline: 471 organisms have orthologs with human gene Arfgef2
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GABA receptor binding	ISO Inferred from Sequence Orthology more info
enables guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
enables myosin binding	ISO Inferred from Sequence Orthology more info
enables protein kinase A regulatory subunit binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Golgi to plasma membrane transport	ISO Inferred from Sequence Orthology more info
involved_in endomembrane system organization	ISO Inferred from Sequence Orthology more info
involved_in endosome organization	ISO Inferred from Sequence Orthology more info
involved_in exocytosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
involved_in receptor recycling	ISO Inferred from Sequence Orthology more info
involved_in regulation of ARF protein signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in asymmetric synapse	ISO Inferred from Sequence Orthology more info
located_in axonemal microtubule	ISO Inferred from Sequence Orthology more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
located_in endosome	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in microtubule organizing center	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	ISO Inferred from Sequence Orthology more info
is_active_in presynapse	ISO Inferred from Sequence Orthology more info
located_in recycling endosome	ISO Inferred from Sequence Orthology more info
located_in symmetric synapse	ISO Inferred from Sequence Orthology more info
located_in synapse	IEA Inferred from Electronic Annotation more info
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: brefeldin A-inhibited guanine nucleotide-exchange protein 2

Names: brefeldin A-inhibited GEP 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001085495.2 → NP_001078964.1 brefeldin A-inhibited guanine nucleotide-exchange protein 2

See identical proteins and their annotated locations for NP_001078964.1

Status: VALIDATED

Source sequence(s)

AL591703, AL591911

Consensus CDS

CCDS38335.1

UniProtKB/Swiss-Prot

A2A5R2

Related

ENSMUSP00000096677.4, ENSMUST00000099078.10

Conserved Domains (1) summary

PLN03076
Location:11 → 1718

PLN03076; ARF guanine nucleotide exchange factor (ARF-GEF); Provisional

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

166647371..166739972

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006500484.4 → XP_006500547.1 brefeldin A-inhibited guanine nucleotide-exchange protein 2 isoform X2

Conserved Domains (1) summary

PLN03076
Location:11 → 1695

PLN03076; ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
XM_006500483.4 → XP_006500546.1 brefeldin A-inhibited guanine nucleotide-exchange protein 2 isoform X1

Conserved Domains (1) summary

PLN03076
Location:11 → 1717

PLN03076; ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
XM_036162763.1 → XP_036018656.1 brefeldin A-inhibited guanine nucleotide-exchange protein 2 isoform X3

Conserved Domains (1) summary

PLN03076
Location:11 → 1694

PLN03076; ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
XM_030252278.2 → XP_030108138.1 brefeldin A-inhibited guanine nucleotide-exchange protein 2 isoform X4

Conserved Domains (1) summary

PLN03076
Location:189 → 1530

PLN03076; ARF guanine nucleotide exchange factor (ARF-GEF); Provisional