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DCTN2 dynactin subunit 2 [ Homo sapiens (human) ]

Gene ID: 10540, updated on 5-Sep-2021

Summary

Official Symbol
DCTN2provided by HGNC
Official Full Name
dynactin subunit 2provided by HGNC
Primary source
HGNC:HGNC:2712
See related
Ensembl:ENSG00000175203 MIM:607376
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RBP50; DCTN50; HEL-S-77; DYNAMITIN
Summary
This gene encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4-5 copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that may mediate association with self or other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and may affix p150 in place. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2012]
Expression
Ubiquitous expression in brain (RPKM 42.2), esophagus (RPKM 36.9) and 25 other tissues See more
Orthologs
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Genomic context

See DCTN2 in Genome Data Viewer
Location:
12q13.3
Exon count:
19
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (57530051..57547216, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (57923834..57940975, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene methionyl-tRNA synthetase 1 Neighboring gene microRNA 6758 Neighboring gene DNA damage inducible transcript 3 Neighboring gene microRNA 616 Neighboring gene methyl-CpG binding domain protein 6 Neighboring gene kinesin family member 5A Neighboring gene phosphatidylinositol-5-phosphate 4-kinase type 2 gamma

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Overexpression of p50/dynamitin leads to a marked relocalization of vRNA and viral structural protein Gag to the cell periphery with late endosomes and a several fold increase in HIV-1 production PubMed
capsid gag Over-expression of p50/dynamitin results in upregulated amounts of pelletable HIV-1 CA cores in infected cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables spectrin binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in melanosome transport IEA
Inferred from Electronic Annotation
more info
 
involved_in mitotic metaphase plate congression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitotic spindle organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitotic spindle organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitotic spindle organization ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to centrosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
part_of dynactin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of dynactin complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of dynein complex IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular exosome HDA PubMed 
located_in growth cone IEA
Inferred from Electronic Annotation
more info
 
located_in kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 
located_in vesicle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
dynactin subunit 2
Names
50 kDa dynein-associated polypeptide
dynactin 2 (p50)
dynactin complex 50 kDa subunit
epididymis secretory protein Li 77
epididymis secretory sperm binding protein
p50 dynamitin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047120.1 RefSeqGene

    Range
    5001..22282
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001261412.2NP_001248341.1  dynactin subunit 2 isoform 2

    See identical proteins and their annotated locations for NP_001248341.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AK098794, DB027733, DB569305
    Consensus CDS
    CCDS73489.1
    UniProtKB/Swiss-Prot
    Q13561
    Related
    ENSP00000439376.2, ENST00000543672.6
    Conserved Domains (1) summary
    pfam04912
    Location:16401
    Dynamitin; Dynamitin
  2. NM_001261413.2NP_001248342.1  dynactin subunit 2 isoform 3

    See identical proteins and their annotated locations for NP_001248342.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two exons in the 5' coding region but maintains the reading frame, compared to variant 1. The resulting isoform (3) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    BC009468, DB027733, DB569305
    Consensus CDS
    CCDS58245.1
    UniProtKB/Swiss-Prot
    Q13561
    Related
    ENSP00000447824.1, ENST00000548249.6
    Conserved Domains (1) summary
    pfam04912
    Location:16399
    Dynamitin; Dynamitin
  3. NM_001348065.2NP_001334994.1  dynactin subunit 2 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC022506
    Conserved Domains (1) summary
    pfam04912
    Location:59444
    Dynamitin
  4. NM_001348066.2NP_001334995.1  dynactin subunit 2 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC022506, AK096242
    UniProtKB/TrEMBL
    B3KTX4
    Conserved Domains (1) summary
    pfam04912
    Location:6376
    Dynamitin
  5. NM_001348067.2NP_001334996.1  dynactin subunit 2 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), as well as variant 7, encodes isoform 6.
    Source sequence(s)
    AC022506, AK292364
    UniProtKB/TrEMBL
    A8K8J9
    Conserved Domains (1) summary
    pfam04912
    Location:2312
    Dynamitin; Dynamitin
  6. NM_001348068.2NP_001334997.1  dynactin subunit 2 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), as well as variant 6, encodes isoform 6.
    Source sequence(s)
    AC022506
    UniProtKB/TrEMBL
    A8K8J9
    Related
    ENSP00000504380.1, ENST00000678653.1
    Conserved Domains (1) summary
    pfam04912
    Location:2312
    Dynamitin; Dynamitin
  7. NM_006400.5NP_006391.1  dynactin subunit 2 isoform 1

    See identical proteins and their annotated locations for NP_006391.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AC022506
    Consensus CDS
    CCDS44930.1
    UniProtKB/Swiss-Prot
    Q13561
    UniProtKB/TrEMBL
    V9HW58
    Related
    ENSP00000408910.3, ENST00000434715.7
    Conserved Domains (1) summary
    pfam04912
    Location:16404
    Dynamitin

RNA

  1. NR_145419.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC022506
    Related
    ENST00000678521.1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    57530051..57547216 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_002957284.1 RNA Sequence

    Related
    ENST00000552390.6
  2. XR_001748556.1 RNA Sequence

    Related
    ENST00000550201.5
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