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Dctn2 dynactin 2 [ Mus musculus (house mouse) ]

Gene ID: 69654, updated on 11-Apr-2024

Summary

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Official Symbol
Dctn2provided by MGI
Official Full Name
dynactin 2provided by MGI
Primary source
MGI:MGI:107733
See related
Ensembl:ENSMUSG00000025410 AllianceGenome:MGI:107733
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p50; RBP50; DCTN-50; GMP23-48K; 2310042E05Rik; C130077D06Rik
Summary
Predicted to enable identical protein binding activity; protein kinase binding activity; and spectrin binding activity. Acts upstream of or within melanosome transport. Located in growth cone. Is expressed in several structures, including adipose tissue; alimentary system; early conceptus; genitourinary system; and nervous system. Orthologous to human DCTN2 (dynactin subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 150.2), adrenal adult (RPKM 99.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 D3; 10 74.5 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (127102131..127117828)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (127266262..127281959)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA F420014N23 gene Neighboring gene phosphatidylinositol-5-phosphate 4-kinase, type II, gamma Neighboring gene STARR-seq mESC enhancer starr_28215 Neighboring gene kinesin family member 5A Neighboring gene STARR-positive B cell enhancer ABC_E9810 Neighboring gene predicted gene, 40800 Neighboring gene STARR-positive B cell enhancer ABC_E10652 Neighboring gene STARR-positive B cell enhancer ABC_E1410 Neighboring gene STARR-positive B cell enhancer ABC_E6939 Neighboring gene methyl-CpG binding domain protein 6 Neighboring gene DNA-damage inducible transcript 3 Neighboring gene methionine-tRNA synthetase 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:126748829-126749012 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Differential roles of kinesin and dynein in translocation of neurofilaments into axonal neurites. Lee S, et al. J Cell Sci, 2011 Apr 1. PMID 21363889
  2. Dynamitin affects cell-surface expression of voltage-gated sodium channel Nav1.5. Chatin B, et al. Biochem J, 2014 Nov 1. PMID 25088759
  3. Regulation of autophagic flux by dynein-mediated autophagosomes trafficking in mouse coronary arterial myocytes. Xu M, et al. Biochim Biophys Acta, 2013 Dec. PMID 24095928, Free PMC Article
  4. Dynactin is essential for growth cone advance. Abe TK, et al. Biochem Biophys Res Commun, 2008 Aug 1. PMID 18477476
  5. Interaction of Cep135 with a p50 dynactin subunit in mammalian centrosomes. Uetake Y, et al. Cell Motil Cytoskeleton, 2004 May. PMID 14983524

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables spectrin binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within melanosome transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule-based process IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic metaphase chromosome alignment ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic spindle organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein localization to centrosome ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of dynactin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of dynactin complex ISO
Inferred from Sequence Orthology
more info
  
part_of dynein complex IEA
Inferred from Electronic Annotation
more info
  
located_in growth cone IDA
Inferred from Direct Assay
more info
 PubMed 
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in vesicle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
dynactin subunit 2
Names
50 kDa dynein-associated polypeptide
dynactin complex 50 kDa subunit
growth cone membrane protein 23-48K
p50 dynamitin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190453.1 → NP_001177382.1  dynactin subunit 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC144852
    Conserved Domains (1) summary
    pfam04912
    Location:16 → 402
    Dynamitin; Dynamitin

  2. NM_001190454.1 → NP_001177383.1  dynactin subunit 2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC144852
    Conserved Domains (1) summary
    pfam04912
    Location:16 → 405
    Dynamitin; Dynamitin

  3. NM_027151.2 → NP_081427.1  dynactin subunit 2 isoform 3

    See identical proteins and their annotated locations for NP_081427.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two in-frame exons in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
    Source sequence(s)
    AC144852, AK144464
    Consensus CDS
    CCDS24234.1
    UniProtKB/Swiss-Prot
    Q99KJ8
    UniProtKB/TrEMBL
    Q3TPZ5
    Related
    ENSMUSP00000026479.10, ENSMUST00000026479.11
    Conserved Domains (1) summary
    pfam04912
    Location:16 → 400
    Dynamitin; Dynamitin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    127102131..127117828
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514055.4 → XP_006514118.1  dynactin subunit 2 isoform X1

    Conserved Domains (1) summary
    pfam04912
    Location:16 → 401
    Dynamitin

  2. XM_036155985.1 → XP_036011878.1  dynactin subunit 2 isoform X2

    Conserved Domains (1) summary
    pfam04912
    Location:2 → 313
    Dynamitin
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99KJ8.3 GenPept UniProtKB/Swiss-Prot:Q99KJ8

Gene LinkOut

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