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IPO7 importin 7 [ Homo sapiens (human) ]

Gene ID: 10527, updated on 24-Nov-2020

Summary

Official Symbol
IPO7provided by HGNC
Official Full Name
importin 7provided by HGNC
Primary source
HGNC:HGNC:9852
See related
Ensembl:ENSG00000205339 MIM:605586
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Imp7; RANBP7
Summary
The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. Similar to importin-beta, this protein prevents the activation of Ran's GTPase by RanGAP1 and inhibits nucleotide exchange on RanGTP, and also binds directly to nuclear pore complexes where it competes for binding sites with importin-beta and transportin. This protein has a Ran-dependent transport cycle and it can cross the nuclear envelope rapidly and in both directions. At least four importin beta-like transport receptors, namely importin beta itself, transportin, RanBP5 and RanBP7, directly bind and import ribosomal proteins. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 38.5), urinary bladder (RPKM 24.9) and 25 other tissues See more
Orthologs

Genomic context

See IPO7 in Genome Data Viewer
Location:
11p15.4
Exon count:
25
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (9384652..9448127)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (9406169..9469674)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene tRNA-Leu (CAA) 5-1 Neighboring gene transmembrane protein 41B Neighboring gene proline rich 13 pseudogene 2 Neighboring gene small nucleolar RNA, H/ACA box 23 Neighboring gene uncharacterized LOC644656 Neighboring gene zinc finger protein 143

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of IPO7 PubMed
High levels of additive and synergic antiretroviral activity are obtained by using antiretroviral compounds (T1249, 3TC, RAL, or IDV) in PM1 cells stably expressing anti-host shRNAs (IPO7, HSPD1, or ATG16) or anti-HIV shRNAs (Pol, RT, or Nef) PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify importin 7 (IPO7), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify importin 7 (IPO7), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify importin 7 (IPO7), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
nef High levels of additive and synergic antiretroviral activity are obtained by using antiretroviral compounds (T1249, 3TC, RAL, or IDV) in PM1 cells stably expressing anti-host shRNAs (IPO7, HSPD1, or ATG16) or anti-HIV shRNAs (Pol, RT, or Nef) PubMed
Pol gag-pol High levels of additive and synergic antiretroviral activity are obtained by using antiretroviral compounds (T1249, 3TC, RAL, or IDV) in PM1 cells stably expressing anti-host shRNAs (IPO7, HSPD1, or ATG16) or anti-HIV shRNAs (Pol, RT, or Nef) PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify importin 7 (IPO7), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Rev rev HIV-1 Rev interacting protein, importin 7 (IPO7), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with IPO7 is decreased by RRE PubMed
Vpr vpr Importin 7, an import receptor for ribosomal proteins and histone H1, is involved in the active nuclear import of the intracellular HIV-1 reverse transcription complex (RTC) containing HIV-1 RT, IN, NC, MA, and Vpr PubMed
integrase gag-pol Amino-acid regions ((235)WKGPAKLLWKG and (262)RRKAK) within the C-terminal domain of HIV-1 integrase (IN) are required for efficient IN/Imp7 interaction PubMed
gag-pol Importin 7, an import receptor for ribosomal proteins and histone H1, is involved in the active nuclear import of the intracellular HIV-1 reverse transcription complex (RTC) containing HIV-1 RT, IN, NC, MA, and Vpr PubMed
matrix gag Importin 7, an import receptor for ribosomal proteins and histone H1, is involved in the active nuclear import of the intracellular HIV-1 reverse transcription complex (RTC) containing HIV-1 RT, IN, NC, MA, and Vpr PubMed
nucleocapsid gag Importin 7, an import receptor for ribosomal proteins and histone H1, is involved in the active nuclear import of the intracellular HIV-1 reverse transcription complex (RTC) containing HIV-1 RT, IN, NC, MA, and Vpr PubMed
reverse transcriptase gag-pol High levels of additive and synergic antiretroviral activity are obtained by using antiretroviral compounds (T1249, 3TC, RAL, or IDV) in PM1 cells stably expressing anti-host shRNAs (IPO7, HSPD1, or ATG16) or anti-HIV shRNAs (Pol, RT, or Nef) PubMed
gag-pol Importin 7, an import receptor for ribosomal proteins and histone H1, is involved in the active nuclear import of the intracellular HIV-1 reverse transcription complex (RTC) containing HIV-1 RT, IN, NC, MA, and Vpr PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ14581, MGC138673

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase regulator activity TAS
Traceable Author Statement
more info
PubMed 
SMAD binding IPI
Inferred from Physical Interaction
more info
PubMed 
histone binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
small GTPase binding IEA
Inferred from Electronic Annotation
more info
 
transporter activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
innate immune response IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cyclin-dependent protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
PubMed 
protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
membrane HDA PubMed 
nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear pore TAS
Traceable Author Statement
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
importin-7
Names
RAN-binding protein 7

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006391.3NP_006382.1  importin-7

    See identical proteins and their annotated locations for NP_006382.1

    Status: REVIEWED

    Source sequence(s)
    AC055845, AC132192
    Consensus CDS
    CCDS31425.1
    UniProtKB/Swiss-Prot
    O95373
    UniProtKB/TrEMBL
    B3KNG9
    Related
    ENSP00000369042.3, ENST00000379719.8
    Conserved Domains (1) summary
    COG5656
    Location:15997
    SXM1; Importin, protein involved in nuclear import [Posttranslational modification, protein turnover, chaperones]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    9384652..9448127
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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