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Ipo7 importin 7 [ Mus musculus (house mouse) ]

Gene ID: 233726, updated on 2-Nov-2024

Summary

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Official Symbol
Ipo7provided by MGI
Official Full Name
importin 7provided by MGI
Primary source
MGI:MGI:2152414
See related
Ensembl:ENSMUSG00000066232 AllianceGenome:MGI:2152414
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Imp7; Ranbp7; C330016G14; A330055O14Rik
Summary
Enables histone binding activity. Involved in negative regulation of osteoblast differentiation; positive regulation of odontoblast differentiation; and positive regulation of protein localization to nucleus. Acts upstream of or within innate immune response and protein import into nucleus. Located in cytoplasm and nucleus. Orthologous to human IPO7 (importin 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 27.1), placenta adult (RPKM 21.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ipo7 in Genome Data Viewer
Location:
7 E3; 7 57.7 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (109617522..109655816)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (110018315..110056609)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 41B Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:117129931-117130114 Neighboring gene RIKEN cDNA 1600010M07 gene Neighboring gene STARR-seq mESC enhancer starr_19812 Neighboring gene predicted gene, 23100 Neighboring gene predicted gene, 25636 Neighboring gene small nucleolar RNA, H/ACA box 23 Neighboring gene STARR-seq mESC enhancer starr_19814 Neighboring gene zinc finger protein 143 Neighboring gene STARR-seq mESC enhancer starr_19815 Neighboring gene STARR-positive B cell enhancer ABC_E293 Neighboring gene STARR-positive B cell enhancer ABC_E6584 Neighboring gene WEE 1 homolog 1 (S. pombe)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Inhibition of importin-7 attenuates ventilator-induced lung injury by targeting nuclear translocation of p38. Ding N, et al. Inflamm Res, 2023 May. PMID 37004548, Free PMC Article
  2. Knockdown of Importin 7 Inhibits Lung Tumorigenesis in K-ras(LA1) Lung Cancer Mice. Lee AY, et al. Anticancer Res, 2017 May. PMID 28476804
  3. Effects of transforming growth factor-β1 on odontoblastic differentiation in dental papilla cells is determined by IPO7 expression level. Zhang Y, et al. Biochem Biophys Res Commun, 2021 Mar 19. PMID 33548622
  4. Nucleocytoplasmic shuttling of the zinc finger protein EZI Is mediated by importin-7-dependent nuclear import and CRM1-independent export mechanisms. Saijou E, et al. J Biol Chem, 2007 Nov 2. PMID 17848547
  5. The regulation of Msx1 by BMP4/pSmad1/5 signaling is mediated by importin7 in dental mesenchymal cells. She Y, et al. Cells Dev, 2022 Mar. PMID 34995814

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inhibition of importin-7 attenuates ventilator-induced lung injury by targeting nuclear translocation of p38.
    Title: Inhibition of importin-7 attenuates ventilator-induced lung injury by targeting nuclear translocation of p38.
  2. IPO7 Promotes Odontoblastic Differentiation and Inhibits Osteoblastic Differentiation Through Regulation of RUNX2 Expression and Translocation.
    Title: IPO7 Promotes Odontoblastic Differentiation and Inhibits Osteoblastic Differentiation Through Regulation of RUNX2 Expression and Translocation.
  3. The regulation of Msx1 by BMP4/pSmad1/5 signaling is mediated by importin7 in dental mesenchymal cells.
    Title: The regulation of Msx1 by BMP4/pSmad1/5 signaling is mediated by importin7 in dental mesenchymal cells.
  4. Effects of transforming growth factor-beta1 on odontoblastic differentiation in dental papilla cells is determined by IPO7 expression level.
    Title: Effects of transforming growth factor-β1 on odontoblastic differentiation in dental papilla cells is determined by IPO7 expression level.
  5. Down-regulation of importin 7 suppresses lung tumorigenesis via suppressing Akt activity and inducing apoptosis
    Title: Knockdown of Importin 7 Inhibits Lung Tumorigenesis in K-ras(LA1) Lung Cancer Mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SMAD binding IEA
Inferred from Electronic Annotation
more info
  
enables SMAD binding ISO
Inferred from Sequence Orthology
more info
  
enables histone binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within innate immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of odontoblast differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein localization to nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of protein localization to nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein import into nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
importin-7
Names
RAN binding protein 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362172.2 → NP_001349101.1  importin-7 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC121995, AC140235
    Conserved Domains (1) summary
    cl27876
    Location:15 → 996
    Cse1; Cse1

  2. NM_181517.5 → NP_852658.2  importin-7 isoform 1

    See identical proteins and their annotated locations for NP_852658.2

    Status: VALIDATED

    Source sequence(s)
    AC121995, AC140235
    Consensus CDS
    CCDS40085.1
    UniProtKB/Swiss-Prot
    Q7TN09, Q7TQ63, Q8BKD8, Q8BYI0, Q9EPL8
    Related
    ENSMUSP00000081782.4, ENSMUST00000084731.5
    Conserved Domains (2) summary
    COG5656
    Location:15 → 997
    SXM1; Importin, protein involved in nuclear import [Posttranslational modification, protein turnover, chaperones]
    pfam03810
    Location:22 → 101
    IBN_N; Importin-beta N-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    109617522..109655816
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9EPL8.2 GenPept UniProtKB/Swiss-Prot:Q9EPL8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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