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Ipo7 importin 7 [ Mus musculus (house mouse) ]

Gene ID: 233726, updated on 13-Dec-2022

Summary

Official Symbol
Ipo7provided by MGI
Official Full Name
importin 7provided by MGI
Primary source
MGI:MGI:2152414
See related
Ensembl:ENSMUSG00000066232 AllianceGenome:MGI:2152414
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Imp7; Ranbp7; C330016G14; A330055O14Rik
Summary
Enables histone binding activity. Acts upstream of or within innate immune response and protein import into nucleus. Predicted to be located in nucleoplasm. Predicted to be active in cytosol and nuclear envelope. Orthologous to human IPO7 (importin 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 27.1), placenta adult (RPKM 21.3) and 28 other tissues See more
Orthologs
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Genomic context

See Ipo7 in Genome Data Viewer
Location:
7; 7 E3
Exon count:
25
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (109617522..109655816)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (110018315..110056609)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 41B Neighboring gene RIKEN cDNA 1600010M07 gene Neighboring gene predicted gene, 23100 Neighboring gene predicted gene, 25636 Neighboring gene small nucleolar RNA, H/ACA box 23 Neighboring gene zinc finger protein 143 Neighboring gene WEE 1 homolog 1 (S. pombe)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SMAD binding ISO
Inferred from Sequence Orthology
more info
 
enables histone binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within protein import into nucleus IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
importin-7
Names
RAN binding protein 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362172.2NP_001349101.1  importin-7 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC121995, AC140235
    Conserved Domains (1) summary
    cl27876
    Location:15996
    Cse1; Cse1
  2. NM_181517.5NP_852658.2  importin-7 isoform 1

    See identical proteins and their annotated locations for NP_852658.2

    Status: VALIDATED

    Source sequence(s)
    AC121995, AC140235
    Consensus CDS
    CCDS40085.1
    UniProtKB/Swiss-Prot
    Q8BYI0, Q9EPL8
    UniProtKB/TrEMBL
    A0A8C6N3R0
    Related
    ENSMUSP00000081782.4, ENSMUST00000084731.5
    Conserved Domains (2) summary
    COG5656
    Location:15997
    SXM1; Importin, protein involved in nuclear import [Posttranslational modification, protein turnover, chaperones]
    pfam03810
    Location:22101
    IBN_N; Importin-beta N-terminal domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    109617522..109655816
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)