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KAT5 lysine acetyltransferase 5 [ Homo sapiens (human) ]

Gene ID: 10524, updated on 24-Nov-2020

Summary

Official Symbol
KAT5provided by HGNC
Official Full Name
lysine acetyltransferase 5provided by HGNC
Primary source
HGNC:HGNC:5275
See related
Ensembl:ENSG00000172977 MIM:601409
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TIP; ESA1; PLIP; TIP60; cPLA2; HTATIP; ZC2HC5; HTATIP1
Summary
The protein encoded by this gene belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 21.5), thyroid (RPKM 20.0) and 25 other tissues See more
Orthologs

Genomic context

See KAT5 in Genome Data Viewer
Location:
11q13.1
Exon count:
14
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (65712018..65719604)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (65479473..65487077)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene RELA divergent transcript Neighboring gene RNA, 7SL, cytoplasmic 309, pseudogene Neighboring gene ribonuclease H2 subunit C Neighboring gene keratin 8 pseudogene 26 Neighboring gene adaptor related protein complex 5 subunit beta 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Discovery and refinement of loci associated with lipid levels.
GeneReviews: Not available
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
GeneReviews: Not available
New loci associated with kidney function and chronic kidney disease.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Reduced levels of Tip60 by HIV-1 Tat is sufficient to restore the effectiveness of antiviral drug maribivar to inhibit beta-herpes virus human cytomegalovirus PubMed
tat HIV-1 Tat forms a quaternary complex with Tip60, Plk1, and cyclin B1 to inhibit Plk1-mediated phosphorylation of cyclin B1 at Ser133 position PubMed
tat HIV-1 Tat induces the polyubiquitination and degradation of Tip60 through p300/CBP-associated E4-type ubiquitin-ligase activity, which results in a dramatic impairment of the Tip60-dependent apoptotic cell response to DNA damage PubMed
tat Tip60 inhibits HIV-1 Tat activation of the HIV-1 LTR promoter in Jurkat cells PubMed
tat Tip60 enhances HIV-1 Tat activation of the HIV-1 LTR promoter in HeLa cells PubMed
tat HIV-1 Tat inhibits Tip60 histone-acetyltransferase activity and abolishes Tip60-dependent transcriptional activity of the Mn-SOD promoter PubMed
tat Tip60 is a nuclear histone acetyltransferase that binds to the N-terminal 31 amino acids of HIV-1 Tat PubMed
matrix gag HIV-1 MA downregulates KAT5 gene expression in HepG2 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
acetyltransferase activity TAS
Traceable Author Statement
more info
 
histone acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone acetyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to histone acetyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
histone acetyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
histone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
peptide-lysine-N-acetyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
repressing transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
transcription coactivator activity TAS
Traceable Author Statement
more info
PubMed 
transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IDA
Inferred from Direct Assay
more info
PubMed 
DNA double-strand break processing TAS
Traceable Author Statement
more info
 
DNA replication TAS
Traceable Author Statement
more info
 
beta-catenin-TCF complex assembly TAS
Traceable Author Statement
more info
 
cellular response to estradiol stimulus IDA
Inferred from Direct Assay
more info
PubMed 
double-strand break repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
double-strand break repair via nonhomologous end joining TAS
Traceable Author Statement
more info
 
histone acetylation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of interleukin-2 production IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-lysine acetylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of autophagy IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein acetylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
proteasome-mediated ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of growth IEA
Inferred from Electronic Annotation
more info
 
regulation of signal transduction by p53 class mediator TAS
Traceable Author Statement
more info
 
response to ionizing radiation IDA
Inferred from Direct Assay
more info
PubMed 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
NuA4 histone acetyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 
Piccolo NuA4 histone acetyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 
Swr1 complex IDA
Inferred from Direct Assay
more info
PubMed 
chromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
transcription regulator complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
histone acetyltransferase KAT5
Names
60 kDa Tat-interactive protein
HIV-1 Tat interactive protein, 60kDa
K(lysine) acetyltransferase 5
K-acetyltransferase 5
Tat interacting protein, 60kDa
cPLA(2)-interacting protein
cPLA2 interacting protein
histone acetyltransferase HTATIP
NP_001193762.1
NP_006379.2
NP_874368.1
NP_874369.1
XP_006718484.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033057.1 RefSeqGene

    Range
    5251..12603
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001206833.2NP_001193762.1  histone acetyltransferase KAT5 isoform 4

    See identical proteins and their annotated locations for NP_001193762.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The resulting protein (isoform 4) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AK304664, BC013211, BU737532
    Consensus CDS
    CCDS55771.1
    UniProtKB/Swiss-Prot
    Q92993
    Related
    ENSP00000434765.1, ENST00000530446.5
    Conserved Domains (2) summary
    PLN00104
    Location:76485
    PLN00104; MYST -like histone acetyltransferase; Provisional
    pfam11717
    Location:4098
    Tudor-knot; RNA binding activity-knot of a chromodomain
  2. NM_006388.4NP_006379.2  histone acetyltransferase KAT5 isoform 2

    See identical proteins and their annotated locations for NP_006379.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), also known as alpha, lacks an alternate in-frame segment, compared to variant 1, resulting in a shorter protein (isoform 2), that has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    BC064912, BU737532, DA043042
    Consensus CDS
    CCDS31610.1
    UniProtKB/Swiss-Prot
    Q92993
    UniProtKB/TrEMBL
    A0A024R597
    Related
    ENSP00000366245.3, ENST00000377046.7
    Conserved Domains (2) summary
    PLN00104
    Location:43504
    PLN00104; MYST -like histone acetyltransferase; Provisional
    pfam11717
    Location:765
    Tudor-knot; RNA binding activity-knot of a chromodomain
  3. NM_182709.3NP_874368.1  histone acetyltransferase KAT5 isoform 3

    See identical proteins and their annotated locations for NP_874368.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), also known as beta, lacks two alternate in-frame segments, compared to variant 1, resulting in a shorter protein (isoform 3), that has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    BC000166, BU737532, DB003934
    Consensus CDS
    CCDS8109.1
    UniProtKB/Swiss-Prot
    Q92993
    UniProtKB/TrEMBL
    A0A024R5E8
    Related
    ENSP00000344955.4, ENST00000352980.8
    Conserved Domains (2) summary
    PLN00104
    Location:43452
    PLN00104; MYST -like histone acetyltransferase; Provisional
    pfam11717
    Location:765
    Tudor-knot; RNA binding activity-knot of a chromodomain
  4. NM_182710.3NP_874369.1  histone acetyltransferase KAT5 isoform 1

    See identical proteins and their annotated locations for NP_874369.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest protein (isoform 1).
    Source sequence(s)
    BC013211, BU737532, DB103287
    Consensus CDS
    CCDS8110.1
    UniProtKB/Swiss-Prot
    Q92993
    Related
    ENSP00000340330.4, ENST00000341318.9
    Conserved Domains (2) summary
    PLN00104
    Location:76537
    PLN00104; MYST -like histone acetyltransferase; Provisional
    pfam11717
    Location:4098
    Tudor-knot; RNA binding activity-knot of a chromodomain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    65712018..65719604
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006718421.3XP_006718484.1  histone acetyltransferase KAT5 isoform X1

    See identical proteins and their annotated locations for XP_006718484.1

    Conserved Domains (2) summary
    PLN00104
    Location:43513
    PLN00104; MYST -like histone acetyltransferase; Provisional
    pfam11717
    Location:765
    Tudor-knot; RNA binding activity-knot of a chromodomain

RNA

  1. XR_001747726.2 RNA Sequence

  2. XR_001747727.2 RNA Sequence

  3. XR_002957116.1 RNA Sequence

  4. XR_001747728.1 RNA Sequence

    Related
    ENST00000534650.5
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