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Kat5 K(lysine) acetyltransferase 5 [ Mus musculus (house mouse) ]

Gene ID: 81601, updated on 12-May-2024

Summary

Official Symbol
Kat5provided by MGI
Official Full Name
K(lysine) acetyltransferase 5provided by MGI
Primary source
MGI:MGI:1932051
See related
Ensembl:ENSMUSG00000024926 AllianceGenome:MGI:1932051
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PLIP; CPLA2; Tip55; Tip60; Htatip; Htatip1
Summary
Enables peptide-lysine-N-acetyltransferase activity and transcription coactivator activity. Involved in peptidyl-lysine acetylation and positive regulation of autophagy. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Part of transcription regulator complex. Is expressed in several structures, including central nervous system; eye; genitourinary system; hemolymphoid system gland; and limb. Orthologous to human KAT5 (lysine acetyltransferase 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E14 (RPKM 21.5), testis adult (RPKM 19.9) and 28 other tissues See more
Orthologs
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Genomic context

See Kat5 in Genome Data Viewer
Location:
19 A; 19 4.34 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (5653042..5661584, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (5603014..5611556, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene ovo like zinc finger 1 Neighboring gene adaptor-related protein complex 5, beta 1 subunit Neighboring gene STARR-seq mESC enhancer starr_45393 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:5601776-5601959 Neighboring gene ribonuclease H2, subunit C Neighboring gene STARR-positive B cell enhancer ABC_E11011 Neighboring gene v-rel reticuloendotheliosis viral oncogene homolog A (avian) Neighboring gene signal-induced proliferation associated gene 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Gene trapped (2) 
  • Targeted (11)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC117972

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables histone H2A acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables histone H2AK5 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables histone H4 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables histone H4K16 acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables histone H4K16 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables histone acetyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables histone acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables peptide butyryltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables peptide crotonyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables peptide-lysine-N-acetyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables peptide-lysine-N-acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables phospholipase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in DNA damage response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
 
involved_in DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA repair-dependent chromatin remodeling ISO
Inferred from Sequence Orthology
more info
 
involved_in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to estradiol stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to glucose starvation ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to glucose stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
 
involved_in double-strand break repair ISO
Inferred from Sequence Orthology
more info
 
involved_in double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in double-strand break repair via homologous recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment of mitotic spindle orientation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_positive_effect lipid droplet disassembly ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of interleukin-2 production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in neural tube development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in neurogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in nucleotide-excision repair ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-lysine acetylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptidyl-lysine acetylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of aggrephagy ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of attachment of mitotic spindle microtubules to kinetochore ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of autophagy IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of autophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of circadian rhythm IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of innate immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mitotic sister chromatid segregation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of myoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein acetylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of regulatory T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of regulatory T cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of triglyceride biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protein acetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein modification process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of apoptotic process NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of chromatin organization NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of double-strand break repair NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of hematopoietic stem cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to ionizing radiation ISO
Inferred from Sequence Orthology
more info
 
involved_in sperm DNA condensation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in spermatid development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of NuA4 histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of NuA4 histone acetyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of NuA4 histone acetyltransferase complex ISO
Inferred from Sequence Orthology
more info
 
part_of Swr1 complex ISO
Inferred from Sequence Orthology
more info
 
part_of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
 
located_in mitotic spindle pole ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
part_of nucleosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus NAS
Non-traceable Author Statement
more info
PubMed 
part_of piccolo histone acetyltransferase complex ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in site of double-strand break ISO
Inferred from Sequence Orthology
more info
 
part_of transcription regulator complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
histone acetyltransferase KAT5
Names
60 kDa Tat-interactive protein
HIV-1 tat interactive protein 1, 60 kDa homolog
HIV-1 tat interactive protein 1, homolog
Tat-interactive protein-60
histone acetyltransferase HTATIP
lysine acetyltransferase 5
protein 2-hydroxyisobutyryltransferase KAT5
protein acetyltransferase KAT5
protein crotonyltransferase KAT5
NP_001186176.1
NP_001186177.1
NP_001186178.1
NP_001349299.1
NP_001349300.1
NP_001349301.1
NP_848752.1
XP_006531923.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199247.1NP_001186176.1  histone acetyltransferase KAT5 isoform 2

    See identical proteins and their annotated locations for NP_001186176.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region, compared to variant 1, and encodes a shorter isoform (2, also known as beta), compared to isoform 1.
    Source sequence(s)
    AF528196, CJ080877, DV648619
    Consensus CDS
    CCDS89314.1
    UniProtKB/TrEMBL
    A2VDH4
    Related
    ENSMUSP00000158391.2, ENSMUST00000236229.2
    Conserved Domains (2) summary
    PLN00104
    Location:43452
    PLN00104; MYST -like histone acetyltransferase; Provisional
    pfam11717
    Location:765
    Tudor-knot; RNA binding activity-knot of a chromodomain
  2. NM_001199248.1NP_001186177.1  histone acetyltransferase KAT5 isoform 3

    See identical proteins and their annotated locations for NP_001186177.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has multiple differences in the 5' coding region, compared to variant 1. It encodes a shorter isoform (3, also known as gamma), compared to isoform 1.
    Source sequence(s)
    AF528195, AK160077, CJ080877, DV648619
    Consensus CDS
    CCDS89313.1
    UniProtKB/TrEMBL
    A0A494BAP7, A2VDH4
    Related
    ENSMUSP00000158181.2, ENSMUST00000235701.2
    Conserved Domains (2) summary
    PLN00104
    Location:76485
    PLN00104; MYST -like histone acetyltransferase; Provisional
    pfam11717
    Location:4098
    Tudor-knot; RNA binding activity-knot of a chromodomain
  3. NM_001199249.1NP_001186178.1  histone acetyltransferase KAT5 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has multiple differences in the 5' and 3' coding regions, compared to variant 1. It encodes a shorter isoform (4, also known as delta) with a unique C-terminus, compared to isoform 1.
    Source sequence(s)
    AK143674, CA317697, CJ080877
    Related
    ENSMUST00000235788.2
    Conserved Domains (2) summary
    pfam11717
    Location:4098
    Tudor-knot; RNA binding activity-knot of a chromodomain
    cl17182
    Location:200378
    NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate
  4. NM_001362370.1NP_001349299.1  histone acetyltransferase KAT5 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC126029, AF528196, BY269987, DV648619
    Related
    ENSMUST00000236964.2
    Conserved Domains (1) summary
    PLN00104
    Location:7293
    PLN00104; MYST -like histone acetyltransferase; Provisional
  5. NM_001362371.1NP_001349300.1  histone acetyltransferase KAT5 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC126029, DV648619
    Conserved Domains (1) summary
    PLN00104
    Location:7293
    PLN00104; MYST -like histone acetyltransferase; Provisional
  6. NM_001362372.1NP_001349301.1  histone acetyltransferase KAT5 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC126029, DV648619
    UniProtKB/TrEMBL
    A2VDH4
    Conserved Domains (2) summary
    PLN00104
    Location:76537
    PLN00104; MYST -like histone acetyltransferase; Provisional
    pfam11717
    Location:4098
    Tudor-knot; RNA binding activity-knot of a chromodomain
  7. NM_178637.2NP_848752.1  histone acetyltransferase KAT5 isoform 1

    See identical proteins and their annotated locations for NP_848752.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1, also known as alpha).
    Source sequence(s)
    AF528195, CJ080877, DV648619
    Consensus CDS
    CCDS29472.1
    UniProtKB/Swiss-Prot
    A0A494B9U8, A1L394, Q3YFI9, Q8CGZ3, Q8CGZ4, Q8CHK4, Q8VIH0
    UniProtKB/TrEMBL
    A2VDH4, Q3UJQ1
    Related
    ENSMUSP00000109271.3, ENSMUST00000113641.4
    Conserved Domains (2) summary
    PLN00104
    Location:43504
    PLN00104; MYST -like histone acetyltransferase; Provisional
    pfam11717
    Location:765
    Tudor-knot; RNA binding activity-knot of a chromodomain

RNA

  1. NR_155544.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC126029, DV648619
    Related
    ENSMUST00000236883.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    5653042..5661584 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531860.3XP_006531923.1  histone acetyltransferase KAT5 isoform X1

    See identical proteins and their annotated locations for XP_006531923.1

    UniProtKB/TrEMBL
    A2VDH4
    Conserved Domains (2) summary
    PLN00104
    Location:227513
    PLN00104; MYST -like histone acetyltransferase; Provisional
    cd18985
    Location:1477
    CBD_TIP60_like; chromo barrel domain of human tat-interactive protein 60, and similar proteins