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NCOA2 nuclear receptor coactivator 2 [ Homo sapiens (human) ]

Gene ID: 10499, updated on 3-Mar-2019

Summary

Official Symbol
NCOA2provided by HGNC
Official Full Name
nuclear receptor coactivator 2provided by HGNC
Primary source
HGNC:HGNC:7669
See related
Ensembl:ENSG00000140396 MIM:601993
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SRC2; TIF2; GRIP1; KAT13C; NCoA-2; bHLHe75
Summary
The protein encoded by this gene functions as a transcriptional coactivator for nuclear hormone receptors, including steroid, thyroid, retinoid, and vitamin D receptors. The encoded protein acts as an intermediary factor for the ligand-dependent activity of these nuclear receptors, which regulate their target genes upon binding of cognate response elements. This gene has been found to be involved in translocations that result in fusions with other genes in various cancers, including the lysine acetyltransferase 6A (KAT6A) gene in acute myeloid leukemia, the ETS variant 6 (ETV6) gene in acute lymphoblastic leukemia, and the hes related family bHLH transcription factor with YRPW motif 1 (HEY1) gene in mesenchymal chondrosarcoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Annotation information
Note: GRIP1 (Gene ID: 23426) and NCOA2 (Gene ID: 10499) share the GRIP1 symbol/alias in common. GRIP1 is a widely used alternative name for nuclear receptor coactivator 2 (NCOA2), which can be confused with the official symbol for glutamate receptor-interacting protein 1 (GRIP1). [06 Jul 2018]
Expression
Ubiquitous expression in testis (RPKM 5.6), esophagus (RPKM 4.0) and 25 other tissues See more
Orthologs

Genomic context

See NCOA2 in Genome Data Viewer
Location:
8q13.3
Exon count:
32
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 8 NC_000008.11 (70109762..70405390, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (71021997..71316062, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene RNA, U1 small nuclear 101, pseudogene Neighboring gene H2A histone family member Z pseudogene 2 Neighboring gene basic transcription factor 3 pseudogene 12 Neighboring gene RNY3 pseudogene 14 Neighboring gene ribosomal protein S18 pseudogene 11 Neighboring gene uncharacterized LOC101926892 Neighboring gene RNA, 7SL, cytoplasmic 203, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Association of genome-wide variation with highly sensitive cardiac troponin-T levels in European Americans and Blacks: a meta-analysis from atherosclerosis risk in communities and cardiovascular health studies.
NHGRI GWA Catalog
Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.
NHGRI GWA Catalog
Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.
NHGRI GWA Catalog
Prognostic implications of genetic variants in advanced non-small cell lung cancer: a genome-wide association study.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat may function as an adaptor molecule, efficiently stimulating the processes of transcription initiation and elongation through potentiation of the coupling of p160 co-activators and the P-TEFb complex PubMed
tat The p160 nuclear receptor co-activator GRIP1 binds to the N-terminal region of HIV-1 Tat (amino acids 1-40) through its basic helix-loop-helix domain (amino acids 1-97) and enhances the transactivating activity of Tat PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC138808

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II proximal promoter sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
aryl hydrocarbon receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
chromatin binding IEA
Inferred from Electronic Annotation
more info
 
nuclear hormone receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear hormone receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
nuclear receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
nuclear receptor transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear receptor transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
thyroid hormone receptor coactivator activity IEA
Inferred from Electronic Annotation
more info
 
transcription coactivator activity ISS
Inferred from Sequence or Structural Similarity
more info
 
transcription coactivator activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
bile acid and bile salt transport TAS
Traceable Author Statement
more info
 
cellular response to Thyroglobulin triiodothyronine IEA
Inferred from Electronic Annotation
more info
 
cellular response to hormone stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
circadian regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
locomotor rhythm IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of glucose metabolic process IEA
Inferred from Electronic Annotation
more info
 
regulation of lipid metabolic process TAS
Traceable Author Statement
more info
 
regulation of transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
response to progesterone IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nuclear body IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein-containing complex IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
nuclear receptor coactivator 2
Names
class E basic helix-loop-helix protein 75
glucocorticoid receptor-interacting protein-1
p160 steroid receptor coactivator 2
transcriptional intermediary factor 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001321703.1NP_001308632.1  nuclear receptor coactivator 2 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1, 2 and 3 all encode isoform a.
    Source sequence(s)
    AC022730, AI652063, AW504723, BC047111, CB270668, CK903771, CN291204, DA691975, X97674
    Consensus CDS
    CCDS47872.1
    UniProtKB/Swiss-Prot
    Q15596
    Conserved Domains (10) summary
    smart00353
    Location:3588
    HLH; helix loop helix domain
    cd00130
    Location:123213
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam07469
    Location:12811338
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:10711116
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:640709
    SRC-1; Steroid receptor coactivator
    pfam09606
    Location:8921372
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam14598
    Location:268378
    PAS_11; PAS domain
    pfam16279
    Location:731816
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:463587
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein
    cl26950
    Location:12691399
    LsmAD; LsmAD domain
  2. NM_001321707.1NP_001308636.1  nuclear receptor coactivator 2 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 all encode isoform a.
    Source sequence(s)
    AC022730, AI652063, AW504723, BC047111, CB270668, CK903771, CN291204, DA691975, X97674
    Consensus CDS
    CCDS47872.1
    UniProtKB/Swiss-Prot
    Q15596
    Conserved Domains (10) summary
    smart00353
    Location:3588
    HLH; helix loop helix domain
    cd00130
    Location:123213
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam07469
    Location:12811338
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:10711116
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:640709
    SRC-1; Steroid receptor coactivator
    pfam09606
    Location:8921372
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam14598
    Location:268378
    PAS_11; PAS domain
    pfam16279
    Location:731816
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:463587
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein
    cl26950
    Location:12691399
    LsmAD; LsmAD domain
  3. NM_001321711.1NP_001308640.1  nuclear receptor coactivator 2 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform 1. Both variants 4 and 5 encode isoform b.
    Source sequence(s)
    AI652063, AK298528, AL712418, AW504723, BC047111, CB270668, CK903771, CN291204, DA691975, X97674
    UniProtKB/Swiss-Prot
    Q15596
    UniProtKB/TrEMBL
    B4DPW8
    Conserved Domains (9) summary
    smart00353
    Location:3588
    HLH; helix loop helix domain
    cd00130
    Location:123213
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00989
    Location:119215
    PAS; PAS fold
    pfam07469
    Location:12121269
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:10021047
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:640709
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:268378
    PAS_11; PAS domain
    pfam16279
    Location:731816
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:463587
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein
  4. NM_001321712.1NP_001308641.1  nuclear receptor coactivator 2 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform 1. Both variants 4 and 5 encode isoform b.
    Source sequence(s)
    AI652063, AK298528, AW504723, BC047111, CB270668, CK002637, CK903771, CN291204, DA691975, X97674
    UniProtKB/Swiss-Prot
    Q15596
    UniProtKB/TrEMBL
    B4DPW8
    Conserved Domains (9) summary
    smart00353
    Location:3588
    HLH; helix loop helix domain
    cd00130
    Location:123213
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00989
    Location:119215
    PAS; PAS fold
    pfam07469
    Location:12121269
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:10021047
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:640709
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:268378
    PAS_11; PAS domain
    pfam16279
    Location:731816
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:463587
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein
  5. NM_001321713.1NP_001308642.1  nuclear receptor coactivator 2 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) contains alternate 5' exon structure, and it thus differs in the 5' UTR and initiates translation from a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AI652063, AW504723, BC047111, CB270668, CK002637, CK903771, CN291204, DA691975, X97674
    UniProtKB/Swiss-Prot
    Q15596
    Conserved Domains (6) summary
    pfam07469
    Location:11271184
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:917962
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:486555
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:114224
    PAS_11; PAS domain
    pfam16279
    Location:577662
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:309433
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein
  6. NM_006540.4NP_006531.1  nuclear receptor coactivator 2 isoform a

    See identical proteins and their annotated locations for NP_006531.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 all encode isoform a.
    Source sequence(s)
    AL712418, AW504723, BC047111, CB270668, CK903771, CN291204, DA691975, X97674
    Consensus CDS
    CCDS47872.1
    UniProtKB/Swiss-Prot
    Q15596
    Related
    ENSP00000399968.2, ENST00000452400.6
    Conserved Domains (10) summary
    smart00353
    Location:3588
    HLH; helix loop helix domain
    cd00130
    Location:123213
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam07469
    Location:12811338
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:10711116
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:640709
    SRC-1; Steroid receptor coactivator
    pfam09606
    Location:8921372
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam14598
    Location:268378
    PAS_11; PAS domain
    pfam16279
    Location:731816
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:463587
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein
    cl26950
    Location:12691399
    LsmAD; LsmAD domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p12 Primary Assembly

    Range
    70109762..70405390 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017012961.2XP_016868450.1  nuclear receptor coactivator 2 isoform X1

  2. XM_017012963.2XP_016868452.1  nuclear receptor coactivator 2 isoform X1

  3. XM_017012966.2XP_016868455.1  nuclear receptor coactivator 2 isoform X1

  4. XM_017012968.2XP_016868457.1  nuclear receptor coactivator 2 isoform X1

  5. XM_017012962.2XP_016868451.1  nuclear receptor coactivator 2 isoform X1

  6. XM_017012964.2XP_016868453.1  nuclear receptor coactivator 2 isoform X1

  7. XM_017012967.2XP_016868456.1  nuclear receptor coactivator 2 isoform X1

  8. XM_017012971.2XP_016868460.1  nuclear receptor coactivator 2 isoform X1

  9. XM_017012970.2XP_016868459.1  nuclear receptor coactivator 2 isoform X1

  10. XM_017012969.2XP_016868458.1  nuclear receptor coactivator 2 isoform X1

  11. XM_017012972.2XP_016868461.1  nuclear receptor coactivator 2 isoform X2

  12. XM_017012973.2XP_016868462.1  nuclear receptor coactivator 2 isoform X3

    Related
    ENSP00000430148.2, ENST00000518287.6
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