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Ncoa2 nuclear receptor coactivator 2 [ Mus musculus (house mouse) ]

Gene ID: 17978, updated on 8-Dec-2022

Summary

Official Symbol
Ncoa2provided by MGI
Official Full Name
nuclear receptor coactivator 2provided by MGI
Primary source
MGI:MGI:1276533
See related
Ensembl:ENSMUSG00000005886 AllianceGenome:MGI:1276533
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TIF2; Grip1; SRC-2; GRIP-1; KAT13C; NCoA-2; bHLHe75; D1Ertd433e
Summary
Enables several functions, including RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; chromatin binding activity; and nuclear receptor coactivator activity. Involved in circadian regulation of gene expression; locomotor rhythm; and regulation of glucose metabolic process. Acts upstream of or within several processes, including cellular response to Thyroglobulin triiodothyronine; regulation of transcription by RNA polymerase II; and response to progesterone. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; hemolymphoid system; and sensory organ. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human NCOA2 (nuclear receptor coactivator 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 10.9), thymus adult (RPKM 8.7) and 28 other tissues See more
Orthologs
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Genomic context

See Ncoa2 in Genome Data Viewer
Location:
1 A3; 1 4.12 cM
Exon count:
34
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (13209329..13444451, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (13139105..13374227, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39592 Neighboring gene PR domain containing 14 Neighboring gene predicted gene, 23169 Neighboring gene predicted gene, 51852 Neighboring gene predicted gene, 39595 Neighboring gene signal recognition particle receptor ('docking protein') pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (5)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • 9530095N19

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA polymerase binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables aryl hydrocarbon receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables nuclear estrogen receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables nuclear glucocorticoid receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables nuclear progesterone receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables nuclear receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nuclear receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables nuclear receptor coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nuclear receptor coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables nuclear receptor coactivator activity ISO
Inferred from Sequence Orthology
more info
 
enables nuclear retinoic acid receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables nuclear retinoid X receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables nuclear thyroid hormone receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription coactivator activity IGI
Inferred from Genetic Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to Thyroglobulin triiodothyronine IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to hormone stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in circadian regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in circadian rhythm IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in locomotor rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mRNA transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peroxisome proliferator activated receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of adipose tissue development NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of female receptivity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of glucocorticoid receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cellular response to insulin stimulus NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of glucose metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of lipid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within response to progesterone IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex ISO
Inferred from Sequence Orthology
more info
 
part_of RNA polymerase II transcription regulator complex NAS
Non-traceable Author Statement
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
part_of transcription regulator complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of transcription regulator complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
nuclear receptor coactivator 2
Names
glucocorticoid receptor interacting protein 1
steroid receptor coactivator 2
transcriptional intermediary factor 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001302702.1NP_001289631.1  nuclear receptor coactivator 2 isoform b

    See identical proteins and their annotated locations for NP_001289631.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (c) differs in the 5' UTR and lacks an in-frame exon compared to variant a. The encoded isoform (b) is shorter than isoform a.
    Source sequence(s)
    AC091248, AK028964, AK035719, AK038781, AK042893, AK087443, BP761474, BU703942
    Consensus CDS
    CCDS35514.1
    UniProtKB/TrEMBL
    E9PV80, Q8BN74, Q8C961, Q8CAG7, Q8CBM5, Q8CE59
    Related
    ENSMUSP00000080413.5, ENSMUST00000081713.11
    Conserved Domains (9) summary
    smart00091
    Location:118175
    PAS; PAS domain
    pfam09606
    Location:10561334
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd18950
    Location:2891
    bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
    pfam07469
    Location:12101267
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:10021046
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:636709
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:268378
    PAS_11; PAS domain
    pfam16279
    Location:731816
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:463587
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein
  2. NM_008678.3NP_032704.2  nuclear receptor coactivator 2 isoform a

    See identical proteins and their annotated locations for NP_032704.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (a) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC091248, AK028964, AK035719, AK038781, AK042893, AK052117, AK087443, BP761474, BU703942
    Consensus CDS
    CCDS35515.1
    UniProtKB/Swiss-Prot
    P97759, Q61026
    UniProtKB/TrEMBL
    Q8BN74, Q8C961, Q8CAG7, Q8CBM5, Q8CE59
    Related
    ENSMUSP00000006037.7, ENSMUST00000006037.13
    Conserved Domains (9) summary
    smart00091
    Location:118175
    PAS; PAS domain
    pfam09606
    Location:9211424
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd18950
    Location:2891
    bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
    pfam07469
    Location:12791336
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:10711115
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:636709
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:268378
    PAS_11; PAS domain
    pfam16279
    Location:731816
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:463587
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    13209329..13444451 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162692.1XP_036018585.1  nuclear receptor coactivator 2 isoform X4

    UniProtKB/Swiss-Prot
    P97759
    Conserved Domains (9) summary
    smart00091
    Location:118175
    PAS; PAS domain
    pfam09606
    Location:9211424
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd18950
    Location:2891
    bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
    pfam07469
    Location:12791336
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:10711115
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:636709
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:268378
    PAS_11; PAS domain
    pfam16279
    Location:731816
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:463587
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein
  2. XM_036162710.1XP_036018603.1  nuclear receptor coactivator 2 isoform X7

    UniProtKB/TrEMBL
    E9PV80
    Related
    ENSMUSP00000069509.7, ENSMUST00000068304.13
    Conserved Domains (9) summary
    smart00091
    Location:118175
    PAS; PAS domain
    pfam09606
    Location:10561334
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd18950
    Location:2891
    bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
    pfam07469
    Location:12101267
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:10021046
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:636709
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:268378
    PAS_11; PAS domain
    pfam16279
    Location:731816
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:463587
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein
  3. XM_030252088.1XP_030107948.1  nuclear receptor coactivator 2 isoform X3

    Conserved Domains (8) summary
    smart00091
    Location:118175
    PAS; PAS domain
    pfam08815
    Location:10761121
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam07469
    Location:12841340
    DUF1518; Domain of unknown function (DUF1518)
    pfam08832
    Location:636709
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:268378
    PAS_11; PAS domain
    pfam16279
    Location:731816
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:463587
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein
    cd18950
    Location:2891
    bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
  4. XM_036162655.1XP_036018548.1  nuclear receptor coactivator 2 isoform X1

    Conserved Domains (9) summary
    smart00091
    Location:118175
    PAS; PAS domain
    pfam09606
    Location:11301408
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd18950
    Location:2891
    bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
    pfam07469
    Location:12841341
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:10761120
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:636709
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:268378
    PAS_11; PAS domain
    pfam16279
    Location:731816
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:463587
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein
  5. XM_030252095.2XP_030107955.1  nuclear receptor coactivator 2 isoform X7

    UniProtKB/TrEMBL
    E9PV80
    Conserved Domains (9) summary
    smart00091
    Location:118175
    PAS; PAS domain
    pfam09606
    Location:10561334
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd18950
    Location:2891
    bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
    pfam07469
    Location:12101267
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:10021046
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:636709
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:268378
    PAS_11; PAS domain
    pfam16279
    Location:731816
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:463587
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein
  6. XM_036162694.1XP_036018587.1  nuclear receptor coactivator 2 isoform X4

    UniProtKB/Swiss-Prot
    P97759
    Conserved Domains (9) summary
    smart00091
    Location:118175
    PAS; PAS domain
    pfam09606
    Location:9211424
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd18950
    Location:2891
    bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
    pfam07469
    Location:12791336
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:10711115
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:636709
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:268378
    PAS_11; PAS domain
    pfam16279
    Location:731816
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:463587
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein
  7. XM_036162714.1XP_036018607.1  nuclear receptor coactivator 2 isoform X7

    UniProtKB/TrEMBL
    E9PV80
    Conserved Domains (9) summary
    smart00091
    Location:118175
    PAS; PAS domain
    pfam09606
    Location:10561334
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd18950
    Location:2891
    bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
    pfam07469
    Location:12101267
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:10021046
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:636709
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:268378
    PAS_11; PAS domain
    pfam16279
    Location:731816
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:463587
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein
  8. XM_036162698.1XP_036018591.1  nuclear receptor coactivator 2 isoform X4

    UniProtKB/Swiss-Prot
    P97759
    Conserved Domains (9) summary
    smart00091
    Location:118175
    PAS; PAS domain
    pfam09606
    Location:9211424
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd18950
    Location:2891
    bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
    pfam07469
    Location:12791336
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:10711115
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:636709
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:268378
    PAS_11; PAS domain
    pfam16279
    Location:731816
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:463587
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein
  9. XM_036162703.1XP_036018596.1  nuclear receptor coactivator 2 isoform X6

    Conserved Domains (9) summary
    smart00091
    Location:118175
    PAS; PAS domain
    pfam09606
    Location:10561334
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd18950
    Location:2891
    bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
    pfam07469
    Location:12101267
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:10021046
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:636709
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:268378
    PAS_11; PAS domain
    pfam16279
    Location:731816
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:463587
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein
  10. XM_030252090.2XP_030107950.1  nuclear receptor coactivator 2 isoform X5

    Conserved Domains (10) summary
    TIGR01628
    Location:9021021
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    smart00091
    Location:118175
    PAS; PAS domain
    pfam08815
    Location:10071052
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam09606
    Location:10701360
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam07469
    Location:12151271
    DUF1518; Domain of unknown function (DUF1518)
    pfam08832
    Location:636709
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:268378
    PAS_11; PAS domain
    pfam16279
    Location:731816
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:463587
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein
    cd18950
    Location:2891
    bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
  11. XM_030252087.2XP_030107947.1  nuclear receptor coactivator 2 isoform X2

    Conserved Domains (9) summary
    smart00091
    Location:118175
    PAS; PAS domain
    pfam08815
    Location:10711116
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam09606
    Location:9211424
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam07469
    Location:12791335
    DUF1518; Domain of unknown function (DUF1518)
    pfam08832
    Location:636709
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:268378
    PAS_11; PAS domain
    pfam16279
    Location:731816
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:463587
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein
    cd18950
    Location:2891
    bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
  12. XM_030252072.2XP_030107932.1  nuclear receptor coactivator 2 isoform X1

    Conserved Domains (9) summary
    smart00091
    Location:118175
    PAS; PAS domain
    pfam09606
    Location:11301408
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd18950
    Location:2891
    bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
    pfam07469
    Location:12841341
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:10761120
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:636709
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:268378
    PAS_11; PAS domain
    pfam16279
    Location:731816
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:463587
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein
  13. XM_030252093.2XP_030107953.1  nuclear receptor coactivator 2 isoform X6

    Conserved Domains (9) summary
    smart00091
    Location:118175
    PAS; PAS domain
    pfam09606
    Location:10561334
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd18950
    Location:2891
    bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
    pfam07469
    Location:12101267
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:10021046
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:636709
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:268378
    PAS_11; PAS domain
    pfam16279
    Location:731816
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:463587
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein
  14. XM_017319241.3XP_017174730.1  nuclear receptor coactivator 2 isoform X5

    Conserved Domains (10) summary
    TIGR01628
    Location:9021021
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    smart00091
    Location:118175
    PAS; PAS domain
    pfam08815
    Location:10071052
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam09606
    Location:10701360
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam07469
    Location:12151271
    DUF1518; Domain of unknown function (DUF1518)
    pfam08832
    Location:636709
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:268378
    PAS_11; PAS domain
    pfam16279
    Location:731816
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:463587
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein
    cd18950
    Location:2891
    bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
  15. XM_017319229.3XP_017174718.1  nuclear receptor coactivator 2 isoform X1

    Conserved Domains (9) summary
    smart00091
    Location:118175
    PAS; PAS domain
    pfam09606
    Location:11301408
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd18950
    Location:2891
    bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
    pfam07469
    Location:12841341
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:10761120
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:636709
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:268378
    PAS_11; PAS domain
    pfam16279
    Location:731816
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:463587
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein
  16. XM_030252082.2XP_030107942.1  nuclear receptor coactivator 2 isoform X1

    Conserved Domains (9) summary
    smart00091
    Location:118175
    PAS; PAS domain
    pfam09606
    Location:11301408
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd18950
    Location:2891
    bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
    pfam07469
    Location:12841341
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:10761120
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:636709
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:268378
    PAS_11; PAS domain
    pfam16279
    Location:731816
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:463587
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein
  17. XM_030252068.2XP_030107928.1  nuclear receptor coactivator 2 isoform X1

    Conserved Domains (9) summary
    smart00091
    Location:118175
    PAS; PAS domain
    pfam09606
    Location:11301408
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd18950
    Location:2891
    bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
    pfam07469
    Location:12841341
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:10761120
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:636709
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:268378
    PAS_11; PAS domain
    pfam16279
    Location:731816
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:463587
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein
  18. XM_017319235.3XP_017174724.1  nuclear receptor coactivator 2 isoform X1

    Conserved Domains (9) summary
    smart00091
    Location:118175
    PAS; PAS domain
    pfam09606
    Location:11301408
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd18950
    Location:2891
    bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
    pfam07469
    Location:12841341
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:10761120
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:636709
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:268378
    PAS_11; PAS domain
    pfam16279
    Location:731816
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:463587
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein
  19. XM_036162665.1XP_036018558.1  nuclear receptor coactivator 2 isoform X1

    Conserved Domains (9) summary
    smart00091
    Location:118175
    PAS; PAS domain
    pfam09606
    Location:11301408
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd18950
    Location:2891
    bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
    pfam07469
    Location:12841341
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:10761120
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:636709
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:268378
    PAS_11; PAS domain
    pfam16279
    Location:731816
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:463587
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein
  20. XM_036162709.1XP_036018602.1  nuclear receptor coactivator 2 isoform X6

    Conserved Domains (9) summary
    smart00091
    Location:118175
    PAS; PAS domain
    pfam09606
    Location:10561334
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd18950
    Location:2891
    bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
    pfam07469
    Location:12101267
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:10021046
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:636709
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:268378
    PAS_11; PAS domain
    pfam16279
    Location:731816
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:463587
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein
  21. XM_017319233.3XP_017174722.1  nuclear receptor coactivator 2 isoform X1

    Conserved Domains (9) summary
    smart00091
    Location:118175
    PAS; PAS domain
    pfam09606
    Location:11301408
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd18950
    Location:2891
    bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
    pfam07469
    Location:12841341
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:10761120
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:636709
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:268378
    PAS_11; PAS domain
    pfam16279
    Location:731816
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:463587
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein
  22. XM_030252070.2XP_030107930.1  nuclear receptor coactivator 2 isoform X1

    Conserved Domains (9) summary
    smart00091
    Location:118175
    PAS; PAS domain
    pfam09606
    Location:11301408
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd18950
    Location:2891
    bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
    pfam07469
    Location:12841341
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:10761120
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:636709
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:268378
    PAS_11; PAS domain
    pfam16279
    Location:731816
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:463587
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein
  23. XM_017319232.3XP_017174721.1  nuclear receptor coactivator 2 isoform X1

    Conserved Domains (9) summary
    smart00091
    Location:118175
    PAS; PAS domain
    pfam09606
    Location:11301408
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd18950
    Location:2891
    bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
    pfam07469
    Location:12841341
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:10761120
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:636709
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:268378
    PAS_11; PAS domain
    pfam16279
    Location:731816
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:463587
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein
  24. XM_030252066.2XP_030107926.1  nuclear receptor coactivator 2 isoform X1

    Conserved Domains (9) summary
    smart00091
    Location:118175
    PAS; PAS domain
    pfam09606
    Location:11301408
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd18950
    Location:2891
    bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
    pfam07469
    Location:12841341
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:10761120
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:636709
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:268378
    PAS_11; PAS domain
    pfam16279
    Location:731816
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:463587
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein
  25. XM_036162671.1XP_036018564.1  nuclear receptor coactivator 2 isoform X1

    Conserved Domains (9) summary
    smart00091
    Location:118175
    PAS; PAS domain
    pfam09606
    Location:11301408
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd18950
    Location:2891
    bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
    pfam07469
    Location:12841341
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:10761120
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:636709
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:268378
    PAS_11; PAS domain
    pfam16279
    Location:731816
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:463587
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein
  26. XM_036162677.1XP_036018570.1  nuclear receptor coactivator 2 isoform X1

    Conserved Domains (9) summary
    smart00091
    Location:118175
    PAS; PAS domain
    pfam09606
    Location:11301408
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd18950
    Location:2891
    bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
    pfam07469
    Location:12841341
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:10761120
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:636709
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:268378
    PAS_11; PAS domain
    pfam16279
    Location:731816
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:463587
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein
  27. XM_030252075.2XP_030107935.1  nuclear receptor coactivator 2 isoform X1

    Conserved Domains (9) summary
    smart00091
    Location:118175
    PAS; PAS domain
    pfam09606
    Location:11301408
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd18950
    Location:2891
    bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
    pfam07469
    Location:12841341
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:10761120
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:636709
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:268378
    PAS_11; PAS domain
    pfam16279
    Location:731816
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:463587
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein
  28. XM_030252077.2XP_030107937.1  nuclear receptor coactivator 2 isoform X1

    Conserved Domains (9) summary
    smart00091
    Location:118175
    PAS; PAS domain
    pfam09606
    Location:11301408
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd18950
    Location:2891
    bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
    pfam07469
    Location:12841341
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:10761120
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:636709
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:268378
    PAS_11; PAS domain
    pfam16279
    Location:731816
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:463587
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein
  29. XM_030252083.2XP_030107943.1  nuclear receptor coactivator 2 isoform X1

    Conserved Domains (9) summary
    smart00091
    Location:118175
    PAS; PAS domain
    pfam09606
    Location:11301408
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd18950
    Location:2891
    bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
    pfam07469
    Location:12841341
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:10761120
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:636709
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:268378
    PAS_11; PAS domain
    pfam16279
    Location:731816
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:463587
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001077695.1: Suppressed sequence

    Description
    NM_001077695.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.