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FST follistatin [ Homo sapiens (human) ]

Gene ID: 10468, updated on 17-Jun-2019

Summary

Official Symbol
FSTprovided by HGNC
Official Full Name
follistatinprovided by HGNC
Primary source
HGNC:HGNC:3971
See related
Ensembl:ENSG00000134363 MIM:136470
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FS
Summary
Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin. [provided by RefSeq, Jul 2008]
Expression
Broad expression in liver (RPKM 13.6), placenta (RPKM 7.9) and 16 other tissues See more
Orthologs

Genomic context

See FST in Genome Data Viewer
Location:
5q11.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (53480338..53487134)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (52776183..52782964)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene RPL13AP13-RPS19P4 intergenic nontranscribed chromatin-defined enhancer Neighboring gene ribosomal protein S19 pseudogene 4 Neighboring gene NADH:ubiquinone oxidoreductase subunit S4 Neighboring gene long intergenic non-protein coding RNA 2105

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of follistatin (FST) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Antagonism of Activin by Follistatin, organism-specific biosystem (from REACTOME)
    Antagonism of Activin by Follistatin, organism-specific biosystemBoth Follistatin (FST) and Follistatin-like-3 (FSTL3) irreversibly bind Activin dimers and prevent Activin from interacting with its receptor (reviewed in Schneyer et al. 2004 ,Xia and Schneyer 2009)...
  • BMP receptor signaling, organism-specific biosystem (from Pathway Interaction Database)
    BMP receptor signaling, organism-specific biosystem
    BMP receptor signaling
  • Differentiation Pathway, organism-specific biosystem (from WikiPathways)
    Differentiation Pathway, organism-specific biosystemThis pathway provides an overview of the directed differentiation molecules used to induce early and derivative cell lineages from human pluripotent stem cells. The initial version of this pathway is...
  • Integrated Pancreatic Cancer Pathway, organism-specific biosystem (from WikiPathways)
    Integrated Pancreatic Cancer Pathway, organism-specific biosystemAn integrated pathway model which displays the protein-protein interactions (PPIs) among the relevant proteins for pancreatic cancer. This pathway is a collection of different mechanistic protein pat...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by Activin, organism-specific biosystem (from REACTOME)
    Signaling by Activin, organism-specific biosystemActivin was initially discovered as an activator of follicle stimulating hormone in the pituitary gland. It has since been shown to be an important participant in the differentiation of embryonic cel...
  • TGF-beta Receptor Signaling, organism-specific biosystem (from WikiPathways)
    TGF-beta Receptor Signaling, organism-specific biosystemThe Transforming growth factor beta (TGFβ) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiat...
  • TGF-beta signaling pathway, organism-specific biosystem (from KEGG)
    TGF-beta signaling pathway, organism-specific biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...
  • TGF-beta signaling pathway, conserved biosystem (from KEGG)
    TGF-beta signaling pathway, conserved biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
activin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
activin binding IPI
Inferred from Physical Interaction
more info
PubMed 
activin receptor antagonist activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
heparan sulfate proteoglycan binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
follistatin
Names
activin-binding protein
follistatin isoform FST317

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028911.1 RefSeqGene

    Range
    5001..11041
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_006350.4NP_006341.1  follistatin isoform FST317 precursor

    See identical proteins and their annotated locations for NP_006341.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (FST317) uses an alternate splice junction at the 5' end of an exon compared to variant, that causes a frameshift. The resulting isoform (FST317) has a shorter and distinct C-terminus compared to isoform FST344.
    Source sequence(s)
    AC008901, BC004107, BQ949678, DR760015
    Consensus CDS
    CCDS43315.1
    UniProtKB/Swiss-Prot
    P19883
    Related
    ENSP00000380151.2, ENST00000396947.7
    Conserved Domains (2) summary
    smart00280
    Location:117164
    KAZAL; Kazal type serine protease inhibitors
    pfam09289
    Location:95116
    FOLN; Follistatin/Osteonectin-like EGF domain
  2. NM_013409.3NP_037541.1  follistatin isoform FST344 precursor

    See identical proteins and their annotated locations for NP_037541.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (FST344) encodes the longer isoform (FST344).
    Source sequence(s)
    AC008901, BC004107, DR760015
    Consensus CDS
    CCDS3959.1
    UniProtKB/Swiss-Prot
    P19883
    UniProtKB/TrEMBL
    A0A024QZU6
    Related
    ENSP00000256759.3, ENST00000256759.8
    Conserved Domains (2) summary
    smart00280
    Location:117164
    KAZAL; Kazal type serine protease inhibitors
    pfam09289
    Location:95116
    FOLN; Follistatin/Osteonectin-like EGF domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    53480338..53487134
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017008954.1XP_016864443.1  follistatin isoform X5

  2. XM_005248402.4XP_005248459.1  follistatin isoform X6

    Conserved Domains (2) summary
    smart00274
    Location:94117
    FOLN; Follistatin-N-terminal domain-like
    smart00280
    Location:117164
    KAZAL; Kazal type serine protease inhibitors
  3. XM_005248400.4XP_005248457.1  follistatin isoform X1

    Conserved Domains (2) summary
    smart00274
    Location:94117
    FOLN; Follistatin-N-terminal domain-like
    smart00280
    Location:117164
    KAZAL; Kazal type serine protease inhibitors
  4. XM_005248403.4XP_005248460.1  follistatin isoform X7

    See identical proteins and their annotated locations for XP_005248460.1

    Conserved Domains (2) summary
    smart00274
    Location:94117
    FOLN; Follistatin-N-terminal domain-like
    smart00280
    Location:117164
    KAZAL; Kazal type serine protease inhibitors
  5. XM_005248401.4XP_005248458.1  follistatin isoform X3

    See identical proteins and their annotated locations for XP_005248458.1

    Conserved Domains (2) summary
    smart00274
    Location:94117
    FOLN; Follistatin-N-terminal domain-like
    smart00280
    Location:117164
    KAZAL; Kazal type serine protease inhibitors
  6. XM_017008955.1XP_016864444.1  follistatin isoform X8

  7. XM_011543099.2XP_011541401.1  follistatin isoform X2

    Conserved Domains (3) summary
    smart00274
    Location:162185
    FOLN; Follistatin-N-terminal domain-like
    smart00280
    Location:112159
    KAZAL; Kazal type serine protease inhibitors
    pfam09289
    Location:90111
    FOLN; Follistatin/Osteonectin-like EGF domain
  8. XM_024454326.1XP_024310094.1  follistatin isoform X4

    Conserved Domains (3) summary
    smart00274
    Location:162185
    FOLN; Follistatin-N-terminal domain-like
    smart00280
    Location:112159
    KAZAL; Kazal type serine protease inhibitors
    pfam09289
    Location:90111
    FOLN; Follistatin/Osteonectin-like EGF domain
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