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Fst follistatin [ Mus musculus (house mouse) ]

Gene ID: 14313, updated on 12-Mar-2024

Summary

Official Symbol
Fstprovided by MGI
Official Full Name
follistatinprovided by MGI
Primary source
MGI:MGI:95586
See related
Ensembl:ENSMUSG00000021765 AllianceGenome:MGI:95586
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FS
Summary
The protein encoded by this gene binds to and negatively regulates activin, as well as other members of the transforming growth factor beta family, and acts to prevent uncontrolled cellular proliferation. This protein also contains a heparin-binding sequence. It is expressed in many of the tissues in which activin is synthesized and is thought to clear activin from the circulation by attachment to the cell surface. Alternative splicing results in multiple transcript variants that encode multiple protein isoforms, including FST315 and FST288, that differ at their C-terminus. Another isoform, FST303 is thought to be produced by proteolytic cleavage of FST315. These isoforms differ in their localization and in their ability to bind heparin. While FST315 is a circulating protein, FST288 is tissue-bound, and FST303 is gonad-specific. While deletion of all isoforms results in embryonic lethality, expression of just FST288 is sufficient for embryonic development, but the resultant mice have fertility defects. [provided by RefSeq, Aug 2014]
Expression
Biased expression in ovary adult (RPKM 18.5), limb E14.5 (RPKM 6.6) and 14 other tissues See more
Orthologs
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Genomic context

See Fst in Genome Data Viewer
Location:
13 D2.2; 13 64.15 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (114588798..114595522, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (114452262..114458989, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_35756 Neighboring gene STARR-seq mESC enhancer starr_35758 Neighboring gene NADH:ubiquinone oxidoreductase core subunit S4 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:115178183-115178393 Neighboring gene STARR-seq mESC enhancer starr_35759 Neighboring gene STARR-seq mESC enhancer starr_35760 Neighboring gene predicted gene, 41073 Neighboring gene predicted gene, 41074 Neighboring gene STARR-seq mESC enhancer starr_35762 Neighboring gene STARR-seq mESC enhancer starr_35763 Neighboring gene RIKEN cDNA 4930467J12 gene Neighboring gene RIKEN cDNA 4930544M13 gene Neighboring gene STARR-seq mESC enhancer starr_35765 Neighboring gene STARR-seq mESC enhancer starr_35766

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables activin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables activin binding ISO
Inferred from Sequence Orthology
more info
 
enables activin receptor antagonist activity ISO
Inferred from Sequence Orthology
more info
 
enables heparan sulfate proteoglycan binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within BMP signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of ameloblast differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of ameloblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within female gonad development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within gamete generation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within hair follicle morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in hematopoietic progenitor cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within keratinocyte proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of activin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of activin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of epithelial cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of epithelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within odontogenesis of dentin-containing tooth IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within pattern specification process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of hair follicle development ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in regulation of BMP signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within skeletal system development IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
follistatin
Names
activin-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301373.1NP_001288302.1  follistatin isoform FST315 precursor

    See identical proteins and their annotated locations for NP_001288302.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform, FST315 (PMID:17932109).
    Source sequence(s)
    AC110817, AK079916, AW987053, BC144926, BX514305, Z29532
    Consensus CDS
    CCDS88534.1
    UniProtKB/Swiss-Prot
    A6H6P0, P47931
    Related
    ENSMUSP00000022287.7, ENSMUST00000022287.8
    Conserved Domains (3) summary
    smart00274
    Location:167190
    FOLN; Follistatin-N-terminal domain-like
    smart00280
    Location:117164
    KAZAL; Kazal type serine protease inhibitors
    pfam09289
    Location:95116
    FOLN; Follistatin/Osteonectin-like EGF domain
  2. NM_001301375.1NP_001288304.1  follistatin isoform FST288 precursor

    See identical proteins and their annotated locations for NP_001288304.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes FST288 (PMID:20032047), which has a shorter C-terminus, compared to FST315.
    Source sequence(s)
    AC110817, AK079916, AK083556, AW987053, BC144926, BX514305, Z29532
    Consensus CDS
    CCDS88535.1
    UniProtKB/TrEMBL
    Q8BNY0
    Related
    ENSMUSP00000153365.2, ENSMUST00000223640.3
    Conserved Domains (3) summary
    smart00274
    Location:167190
    FOLN; Follistatin-N-terminal domain-like
    smart00280
    Location:117164
    KAZAL; Kazal type serine protease inhibitors
    pfam09289
    Location:95116
    FOLN; Follistatin/Osteonectin-like EGF domain
  3. NM_008046.3NP_032072.1  follistatin isoform 2 precursor

    See identical proteins and their annotated locations for NP_032072.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1. It encodes isoform 2 which is shorter than isoform 1.
    Source sequence(s)
    AC110817, AK079916, AW987053, BC144926, BX514305, Z29532
    Consensus CDS
    CCDS36787.1
    UniProtKB/Swiss-Prot
    P47931
    UniProtKB/TrEMBL
    A0A0R4J026, Q8BNY0
    Related
    ENSMUSP00000156375.2, ENSMUST00000231252.2
    Conserved Domains (3) summary
    smart00274
    Location:167190
    FOLN; Follistatin-N-terminal domain-like
    smart00280
    Location:117164
    KAZAL; Kazal type serine protease inhibitors
    pfam09289
    Location:95116
    FOLN; Follistatin/Osteonectin-like EGF domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    114588798..114595522 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247150.2XP_030103010.1  follistatin isoform X1

    Conserved Domains (3) summary
    smart00274
    Location:167190
    FOLN; Follistatin-N-terminal domain-like
    smart00280
    Location:117164
    KAZAL; Kazal type serine protease inhibitors
    pfam09289
    Location:95116
    FOLN; Follistatin/Osteonectin-like EGF domain