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C1D C1D nuclear receptor corepressor [ Homo sapiens (human) ]

Gene ID: 10438, updated on 21-Dec-2019

Summary

Official Symbol
C1Dprovided by HGNC
Official Full Name
C1D nuclear receptor corepressorprovided by HGNC
Primary source
HGNC:HGNC:29911
See related
Ensembl:ENSG00000197223 MIM:606997
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LRP1; hC1D; Rrp47; SUNCOR; SUN-CoR
Summary
The protein encoded by this gene is a DNA binding and apoptosis-inducing protein and is localized in the nucleus. It is also a Rac3-interacting protein which acts as a corepressor for the thyroid hormone receptor. This protein is thought to regulate TRAX/Translin complex formation. Alternate splicing results in multiple transcript variants that encode the same protein. Multiple pseudogenes of this gene are found on chromosome 10.[provided by RefSeq, Jun 2010]
Expression
Ubiquitous expression in bone marrow (RPKM 17.9), adrenal (RPKM 15.5) and 25 other tissues See more
Orthologs

Genomic context

See C1D in Genome Data Viewer
Location:
2p14
Exon count:
6
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (68041130..68063004, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (68269332..68290159, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1812 Neighboring gene FBXL12 pseudogene 1 Neighboring gene uncharacterized LOC105374789 Neighboring gene small integral membrane protein 30-like

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif modulates the expression of C1D nuclear receptor corepressor (C1D) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC12261, MGC14659

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
nuclear receptor binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription corepressor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
maturation of 5.8S rRNA IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
rRNA processing TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nuclear exosome (RNase complex) TAS
Traceable Author Statement
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus TAS
Traceable Author Statement
more info
PubMed 
transcriptional repressor complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
nuclear nucleic acid-binding protein C1D
Names
C1D DNA-binding protein
C1D nuclear receptor co-repressor
nuclear DNA-binding protein
small unique nuclear receptor co-repressor
small unique nuclear receptor corepressor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190263.2NP_001177192.1  nuclear nucleic acid-binding protein C1D

    See identical proteins and their annotated locations for NP_001177192.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AC079112, AI004680, AK290451
    Consensus CDS
    CCDS1883.1
    UniProtKB/Swiss-Prot
    Q13901
    Related
    ENSP00000386779.1, ENST00000409302.1
    Conserved Domains (1) summary
    pfam04000
    Location:1895
    Sas10_Utp3; Sas10/Utp3/C1D family
  2. NM_001190265.2NP_001177194.1  nuclear nucleic acid-binding protein C1D

    See identical proteins and their annotated locations for NP_001177194.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AC079112, AI004680, DA900336
    Consensus CDS
    CCDS1883.1
    UniProtKB/Swiss-Prot
    Q13901
    Conserved Domains (1) summary
    pfam04000
    Location:1895
    Sas10_Utp3; Sas10/Utp3/C1D family
  3. NM_006333.4NP_006324.1  nuclear nucleic acid-binding protein C1D

    See identical proteins and their annotated locations for NP_006324.1

    Status: REVIEWED

    Description
    Transcript Variant: This transcript represents variant (1). Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AC079112, BC016284, BG505686, BM354091, CN342947
    Consensus CDS
    CCDS1883.1
    UniProtKB/Swiss-Prot
    Q13901
    Related
    ENSP00000348107.3, ENST00000355848.7
    Conserved Domains (1) summary
    pfam04000
    Location:1895
    Sas10_Utp3; Sas10/Utp3/C1D family
  4. NM_173177.3NP_775269.1  nuclear nucleic acid-binding protein C1D

    See identical proteins and their annotated locations for NP_775269.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AC079112, BC009589, BG505686, BM354091, CN342947
    Consensus CDS
    CCDS1883.1
    UniProtKB/Swiss-Prot
    Q13901
    Related
    ENSP00000386468.3, ENST00000410067.7
    Conserved Domains (1) summary
    pfam04000
    Location:1895
    Sas10_Utp3; Sas10/Utp3/C1D family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    68041130..68063004 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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