Format

Send to:

Choose Destination

NSA2 NSA2 ribosome biogenesis factor [ Homo sapiens (human) ]

Gene ID: 10412, updated on 8-Nov-2020

Summary

Official Symbol
NSA2provided by HGNC
Official Full Name
NSA2 ribosome biogenesis factorprovided by HGNC
Primary source
HGNC:HGNC:30728
See related
Ensembl:ENSG00000164346 MIM:612497
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HCLG1; TINP1; CDK105; HCL-G1; HUSSY29; HUSSY-29
Summary
This gene encodes a nucleolar protein involved in cell cycle regulation and proliferation. This gene was identified based on sequence similarity to a highly conserved Saccharomyces cerevisiae gene encoding a pre-ribosomal protein, which is involved in large ribosomal subunit biogenesis. The encoded protein is found at elevated levels in diabetic nephropathy. Alternative splicing results in multiple transcript variants. Several related pseudogenes have been identified. [provided by RefSeq, Nov 2012]
Expression
Ubiquitous expression in ovary (RPKM 71.9), lymph node (RPKM 43.0) and 25 other tissues See more
Orthologs

Genomic context

See NSA2 in Genome Data Viewer
Location:
5q13.3
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (74767249..74780113)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (74062816..74072737)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ectodermal-neural cortex 1 Neighboring gene hexosaminidase subunit beta Neighboring gene RNA, U6 small nuclear 658, pseudogene Neighboring gene GTP dependent ribosome recycling factor mitochondrial 2 Neighboring gene RNA, U6 small nuclear 1330, pseudogene Neighboring gene family with sequence similarity 169 member A Neighboring gene actin related protein 2/3 complex subunit 1A pseudogene Neighboring gene uncharacterized LOC441086

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of NSA2 ribosome biogenesis homolog (S. cerevisiae, NSA2) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • YR-29

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
Process Evidence Code Pubs
maturation of 5.8S rRNA IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
maturation of LSU-rRNA IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
nucleolus IEA
Inferred from Electronic Annotation
more info
 
preribosome, large subunit precursor IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ribosome biogenesis protein NSA2 homolog
Names
NSA2, ribosome biogenesis homolog
TGF beta-inducible nuclear protein 1
TGF-beta inducible nuclear protein
hairy cell leukemia protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271665.2NP_001258594.1  ribosome biogenesis protein NSA2 homolog isoform 2

    See identical proteins and their annotated locations for NP_001258594.1

    Status: REVIEWED

    Source sequence(s)
    AC093214
    Consensus CDS
    CCDS75260.1
    UniProtKB/Swiss-Prot
    O95478
    UniProtKB/TrEMBL
    A0A0A0MQZ6
    Related
    ENSP00000296802.6, ENST00000296802.9
    Conserved Domains (1) summary
    cl00880
    Location:4174
    Ribosomal_S8e_like; Eukaryotic/archaeal ribosomal protein S8e and similar proteins
  2. NM_001364506.2NP_001351435.1  ribosome biogenesis protein NSA2 homolog isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC093214
    Conserved Domains (1) summary
    cl00880
    Location:4174
    Ribosomal_S8e_like; Eukaryotic/archaeal ribosomal protein S8e and similar proteins
  3. NM_014886.6NP_055701.1  ribosome biogenesis protein NSA2 homolog isoform 1

    See identical proteins and their annotated locations for NP_055701.1

    Status: REVIEWED

    Source sequence(s)
    AC093214
    Consensus CDS
    CCDS4025.1
    UniProtKB/Swiss-Prot
    O95478
    UniProtKB/TrEMBL
    Q5J7U2
    Related
    ENSP00000483484.1, ENST00000610426.5
    Conserved Domains (1) summary
    cd11381
    Location:4260
    NSA2; pre-ribosomal protein NSA2 (Nop seven-associated 2)

RNA

  1. NR_073403.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC093214
  2. NR_157205.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC093214
  3. NR_157206.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC093214

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    74767249..74780113
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center