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IRF9 interferon regulatory factor 9 [ Homo sapiens (human) ]

Gene ID: 10379, updated on 21-Dec-2022

Summary

Official Symbol
IRF9provided by HGNC
Official Full Name
interferon regulatory factor 9provided by HGNC
Primary source
HGNC:HGNC:6131
See related
Ensembl:ENSG00000213928 MIM:147574; AllianceGenome:HGNC:6131
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p48; IRF-9; ISGF3; ISGF3G
Summary
This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Mutations in this gene result in Immunodeficiency 65. [provided by RefSeq, Jul 2020]
Annotation information
Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
Expression
Ubiquitous expression in spleen (RPKM 55.3), appendix (RPKM 34.4) and 25 other tissues See more
Orthologs
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Genomic context

See IRF9 in Genome Data Viewer
Location:
14q12
Exon count:
10
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (24161265..24166565)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (18359574..18364874)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (24630474..24635774)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:24616442-24616942 Neighboring gene ring finger protein 31 Neighboring gene RNA, 5S ribosomal pseudogene 383 Neighboring gene REC8 meiotic recombination protein Neighboring gene importin 4 Neighboring gene transmembrane 9 superfamily member 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: RNF31

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
part_of ISGF3 complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in cytoplasm TAS
Traceable Author Statement
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
interferon regulatory factor 9
Names
IFN-alpha-responsive transcription factor subunit
ISGF-3 gamma
ISGF3 p48 subunit
interferon-stimulated gene factor 3 gamma
interferon-stimulated transcription factor 3, gamma (48kD)
interferon-stimulated transcription factor 3, gamma 48kDa
transcriptional regulator ISGF3 subunit gamma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001385400.1NP_001372329.1  interferon regulatory factor 9 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL136295
    Consensus CDS
    CCDS91853.1
    UniProtKB/TrEMBL
    A0A8V8TMJ8
    Related
    ENSP00000514071.1, ENST00000698995.1
    Conserved Domains (2) summary
    pfam00605
    Location:11115
    IRF; Interferon regulatory factor transcription factor
    pfam10401
    Location:227340
    IRF-3; Interferon-regulatory factor 3
  2. NM_001385401.1NP_001372330.1  interferon regulatory factor 9 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL136295
    Consensus CDS
    CCDS91854.1
    UniProtKB/TrEMBL
    H0YNP4
    Related
    ENSP00000454095.2, ENST00000560275.6
    Conserved Domains (2) summary
    pfam00605
    Location:11115
    IRF; Interferon regulatory factor transcription factor
    pfam10401
    Location:227390
    IRF-3; Interferon-regulatory factor 3
  3. NM_001385402.1NP_001372331.1  interferon regulatory factor 9 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL136295
    Consensus CDS
    CCDS91855.1
    UniProtKB/TrEMBL
    A0A8V8TP83
    Related
    ENSP00000514183.1, ENST00000699178.1
    Conserved Domains (1) summary
    pfam00605
    Location:11115
    IRF; Interferon regulatory factor transcription factor
  4. NM_006084.5NP_006075.3  interferon regulatory factor 9 isoform 2

    See identical proteins and their annotated locations for NP_006075.3

    Status: VALIDATED

    Source sequence(s)
    AL136295, BI497082, BI919023
    Consensus CDS
    CCDS9615.1
    UniProtKB/Swiss-Prot
    D3DS61, Q00978
    Related
    ENSP00000380073.3, ENST00000396864.8
    Conserved Domains (2) summary
    pfam00605
    Location:11115
    IRF; Interferon regulatory factor transcription factor
    pfam10401
    Location:218382
    IRF-3; Interferon-regulatory factor 3

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    24161265..24166565
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_018654722.1 Reference GRCh38.p14 PATCHES

    Range
    462243..467543
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    18359574..18364874
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)