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RNF31 ring finger protein 31 [ Homo sapiens (human) ]

Gene ID: 55072, updated on 8-Aug-2021

Summary

Official Symbol
RNF31provided by HGNC
Official Full Name
ring finger protein 31provided by HGNC
Primary source
HGNC:HGNC:16031
See related
Ensembl:ENSG00000092098 MIM:612487
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HOIP; Paul; ZIBRA
Summary
The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. The encoded protein is the E3 ubiquitin-protein ligase component of the linear ubiquitin chain assembly complex. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2015]
Expression
Ubiquitous expression in spleen (RPKM 17.0), testis (RPKM 12.6) and 25 other tissues See more
Orthologs
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Genomic context

See RNF31 in Genome Data Viewer
Location:
14q12
Exon count:
22
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (24146875..24160655)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (24616084..24629864)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene proteasome activator subunit 1 Neighboring gene ER membrane protein complex subunit 9 Neighboring gene microRNA 7703 Neighboring gene proteasome activator subunit 2 Neighboring gene RNA, 5S ribosomal pseudogene 383 Neighboring gene interferon regulatory factor 9 Neighboring gene REC8 meiotic recombination protein Neighboring gene importin 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: IRF9

Homology

Clone Names

  • FLJ10111, FLJ23501, MGC19975

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables K48-linked polyubiquitin modification-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables K63-linked polyubiquitin modification-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables linear polyubiquitin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of CD40 receptor complex ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of LUBAC complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic side of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase RNF31
Names
HOIL-1-interacting protein
RING-type E3 ubiquitin transferase RNF31
zinc in-between-RING-finger ubiquitin-associated domain protein
NP_001297261.1
NP_060469.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_042234.1 RefSeqGene

    Range
    5624..18781
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1315

mRNA and Protein(s)

  1. NM_001310332.2NP_001297261.1  E3 ubiquitin-protein ligase RNF31 isoform 2

    See identical proteins and their annotated locations for NP_001297261.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate first exon and an alternate splice site in a 5' exon compared to variant 1, resulting in the use of a downstream translation initiation site. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AL136295, AY256461, DA462121
    Consensus CDS
    CCDS81792.1
    UniProtKB/Swiss-Prot
    Q96EP0
    Related
    ENSP00000453574.1, ENST00000559275.5
    Conserved Domains (5) summary
    smart00647
    Location:628690
    IBR; In Between Ring fingers
    cd14325
    Location:420474
    UBA_RNF31; UBA domain found in E3 ubiquitin-protein ligase RING finger protein 31 and similar proteins
    sd00029
    Location:153172
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam04981
    Location:548598
    NMD3; NMD3 family
    pfam16678
    Location:332476
    HOIP-UBA; UB-associated-like domain of HOIP or E3 ubiquitin-protein ligase
  2. NM_017999.5NP_060469.4  E3 ubiquitin-protein ligase RNF31 isoform 1

    See identical proteins and their annotated locations for NP_060469.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC012077, CN287790
    Consensus CDS
    CCDS41931.1
    UniProtKB/Swiss-Prot
    Q96EP0
    Related
    ENSP00000315112.6, ENST00000324103.11
    Conserved Domains (6) summary
    cd10464
    Location:52153
    PUB_RNF31; PNGase/UBA or UBX (PUB) domain of the RNF31 (or HOIP) protein
    smart00647
    Location:779841
    IBR; In Between Ring fingers
    cd14325
    Location:571625
    UBA_RNF31; UBA domain found in E3 ubiquitin-protein ligase RING finger protein 31 and similar proteins
    sd00029
    Location:304323
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam04981
    Location:699749
    NMD3; NMD3 family
    pfam16678
    Location:483627
    HOIP-UBA; UB-associated-like domain of HOIP or E3 ubiquitin-protein ligase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    24146875..24160655
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_018654722.1 Reference GRCh38.p13 PATCHES

    Range
    447853..461633
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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