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CDO1 cysteine dioxygenase type 1 [ Homo sapiens (human) ]

Gene ID: 1036, updated on 11-Sep-2019

Summary

Official Symbol
CDO1provided by HGNC
Official Full Name
cysteine dioxygenase type 1provided by HGNC
Primary source
HGNC:HGNC:1795
See related
Ensembl:ENSG00000129596 MIM:603943
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CDO-I
Expression
Biased expression in liver (RPKM 94.6), fat (RPKM 66.8) and 8 other tissues See more
Orthologs

Genomic context

See CDO1 in Genome Data Viewer
Location:
5q22.3
Exon count:
8
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (115804733..115816659, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (115140430..115152405, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene RNA, U2 small nuclear 49, pseudogene Neighboring gene H3 histone pseudogene 24 Neighboring gene autophagy related 12 Neighboring gene adaptor related protein complex 3 subunit sigma 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Meta-analysis of genome-wide association studies for circulating phylloquinone concentrations.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of cysteine dioxygenase, type I (CDO1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cysteine dioxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cysteine dioxygenase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
ferrous iron binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
L-cysteine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
L-cysteine catabolic process TAS
Traceable Author Statement
more info
 
cysteine metabolic process TAS
Traceable Author Statement
more info
PubMed 
inflammatory response TAS
Traceable Author Statement
more info
PubMed 
lactation IEA
Inferred from Electronic Annotation
more info
 
oxidation-reduction process TAS
Traceable Author Statement
more info
PubMed 
response to amino acid IEA
Inferred from Electronic Annotation
more info
 
response to cAMP IEA
Inferred from Electronic Annotation
more info
 
response to ethanol IEA
Inferred from Electronic Annotation
more info
 
response to glucagon IEA
Inferred from Electronic Annotation
more info
 
response to glucocorticoid IEA
Inferred from Electronic Annotation
more info
 
sulfur amino acid biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
taurine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
taurine biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
cysteine dioxygenase type 1
Names
cysteine dioxygenase, type I
NP_001310494.1
NP_001310495.1
NP_001310496.1
NP_001792.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001323565.2NP_001310494.1  cysteine dioxygenase type 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC026449, AK130357, BC024241, DA849625
    UniProtKB/Swiss-Prot
    Q16878
  2. NM_001323566.2NP_001310495.1  cysteine dioxygenase type 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC026449, AK130357, BC024241, DA359016
    UniProtKB/Swiss-Prot
    Q16878
  3. NM_001323567.2NP_001310496.1  cysteine dioxygenase type 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC026449, BC024241, BG720517, BG897741, D85777
    UniProtKB/Swiss-Prot
    Q16878
  4. NM_001801.3NP_001792.2  cysteine dioxygenase type 1 isoform 2

    See identical proteins and their annotated locations for NP_001792.2

    Status: VALIDATED

    Source sequence(s)
    AC026449, AK130357, BC024241
    Consensus CDS
    CCDS4121.1
    UniProtKB/Swiss-Prot
    Q16878
    Related
    ENSP00000250535.4, ENST00000250535.5
    Conserved Domains (1) summary
    pfam05995
    Location:1170
    CDO_I; Cysteine dioxygenase type I

RNA

  1. NR_136618.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC026449, AK130357, BC024241, CK005322
  2. NR_136619.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC026449, AK130357, BC024241, CK005322
  3. NR_136620.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC026449, AK130357, BC024241, BG197197
  4. NR_136621.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC026449, BC024241, BG720517

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    115804733..115816659 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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