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Cdo1 cysteine dioxygenase 1, cytosolic [ Mus musculus (house mouse) ]

Gene ID: 12583, updated on 5-Jan-2023

Summary

Official Symbol
Cdo1provided by MGI
Official Full Name
cysteine dioxygenase 1, cytosolicprovided by MGI
Primary source
MGI:MGI:105925
See related
Ensembl:ENSMUSG00000033022 AllianceGenome:MGI:105925
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cdo; D18Ucla3; 1300002L19Rik
Summary
Predicted to enable cysteine dioxygenase activity and ferrous iron binding activity. Predicted to be involved in several processes, including L-cysteine catabolic process; lactation; and response to glucagon. Predicted to act upstream of or within L-cysteine catabolic process to taurine. Located in cytosol. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human CDO1 (cysteine dioxygenase type 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver adult (RPKM 643.5), subcutaneous fat pad adult (RPKM 274.9) and 6 other tissues See more
Orthologs
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Genomic context

See Cdo1 in Genome Data Viewer
Location:
18 C; 18 24.75 cM
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (46846260..46861569, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (46713193..46728502, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene 3734 Neighboring gene predicted gene, 54021 Neighboring gene autophagy related 12 Neighboring gene adaptor-related protein complex 3, sigma 1 subunit

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cysteine dioxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cysteine dioxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cysteine dioxygenase activity ISO
Inferred from Sequence Orthology
more info
 
enables cysteine dioxygenase activity TAS
Traceable Author Statement
more info
PubMed 
enables dioxygenase activity IEA
Inferred from Electronic Annotation
more info
 
enables ferrous iron binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ferrous iron binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ferrous iron binding ISO
Inferred from Sequence Orthology
more info
 
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nickel cation binding IDA
Inferred from Direct Assay
more info
PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in L-cysteine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in L-cysteine catabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within L-cysteine catabolic process to taurine TAS
Traceable Author Statement
more info
PubMed 
involved_in lactation ISO
Inferred from Sequence Orthology
more info
 
involved_in response to amino acid ISO
Inferred from Sequence Orthology
more info
 
involved_in response to cAMP ISO
Inferred from Sequence Orthology
more info
 
involved_in response to ethanol ISO
Inferred from Sequence Orthology
more info
 
involved_in response to glucagon ISO
Inferred from Sequence Orthology
more info
 
involved_in response to glucocorticoid ISO
Inferred from Sequence Orthology
more info
 
involved_in response to organonitrogen compound ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within taurine metabolic process TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
cysteine dioxygenase type 1
Names
CDO-I
cysteine dioxygenase type I
NP_149026.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033037.4NP_149026.1  cysteine dioxygenase type 1

    See identical proteins and their annotated locations for NP_149026.1

    Status: VALIDATED

    Source sequence(s)
    AK149582, CX222492
    Consensus CDS
    CCDS29234.1
    UniProtKB/Swiss-Prot
    P60334, Q3UED8
    UniProtKB/TrEMBL
    A0A8C6GBS0
    Related
    ENSMUSP00000046517.8, ENSMUST00000035804.9
    Conserved Domains (1) summary
    pfam05995
    Location:2170
    CDO_I; Cysteine dioxygenase type I

RNA

  1. NR_151681.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC123927

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    46846260..46861569 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)