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ZNF267 zinc finger protein 267 [ Homo sapiens (human) ]

Gene ID: 10308, updated on 4-Jul-2021

Summary

Official Symbol
ZNF267provided by HGNC
Official Full Name
zinc finger protein 267provided by HGNC
Primary source
HGNC:HGNC:13060
See related
Ensembl:ENSG00000185947 MIM:604752
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HZF2
Expression
Ubiquitous expression in appendix (RPKM 9.7), lymph node (RPKM 8.0) and 24 other tissues See more
Orthologs
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Genomic context

See ZNF267 in Genome Data Viewer
Location:
16p11.2
Exon count:
6
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (31873807..31917357)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (31885128..31928678)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene vomeronasal 1 receptor 3 Neighboring gene Sharpr-MPRA regulatory region 3948 Neighboring gene RNA binding motif protein 22 pseudogene 13 Neighboring gene PTPRF interacting protein alpha 1 pseudogene Neighboring gene Rho GTPase activating protein 23 pseudogene Neighboring gene immunoglobulin heavy variable 1/OR16-1 (pseudogene)

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 267
Names
zinc finger (C2H2)
zinc finger protein 2
zinc finger protein HZF2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001265588.2NP_001252517.2  zinc finger protein 267 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate internal exon in the 5' region and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC034105
    Conserved Domains (3) summary
    COG5048
    Location:332698
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:350370
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02581
    Location:132
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
  2. NM_003414.6NP_003405.4  zinc finger protein 267 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC034105
    Consensus CDS
    CCDS32440.1
    Related
    ENSP00000300870.10, ENST00000300870.15
    Conserved Domains (3) summary
    smart00349
    Location:464
    KRAB; krueppel associated box
    COG5048
    Location:364730
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:382402
    ZF_C2H2; C2H2 Zn finger [structural motif]

RNA

  1. NR_049749.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) includes an alternate internal exon, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC034105

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    31873807..31917357
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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