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KALRN kalirin RhoGEF kinase [ Panthera tigris (tiger) ]

Gene ID: 102970886, updated on 10-Mar-2024

Summary

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Gene symbol
KALRN
Gene description
kalirin RhoGEF kinase
Gene type
protein coding
RefSeq status
MODEL
Organism
Panthera tigris
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Pantherinae; Panthera
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: C2
Exon count:
63
Annotation release Status Assembly Chr Location
102 current P.tigris_Pti1_mat1.1 (GCF_018350195.1) C2 NC_056668.1 (69086861..69607545)

Chromosome C2 - NC_056668.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC122241940 Neighboring gene drebrin-like protein Neighboring gene uridine monophosphate synthetase Neighboring gene integrin subunit beta 5

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_056668.1 Chromosome C2 Reference P.tigris_Pti1_mat1.1 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in axon guidance IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in postsynaptic density IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
kalirin

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Panthera tigris Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference P.tigris_Pti1_mat1.1 Primary Assembly

Genomic

  1. NC_056668.1 Reference P.tigris_Pti1_mat1.1 Primary Assembly

    Range
    69086861..69607545
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_042998400.1 → XP_042854334.1  kalirin isoform X1

    Conserved Domains (12) summary
    smart00150
    Location:1110 → 1210
    SPEC; Spectrin repeats
    cd11852
    Location:1624 → 1683
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2300 → 2358
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00410
    Location:2455 → 2541
    IG_like; Immunoglobulin like
    smart00516
    Location:23 → 161
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:2545 → 2636
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:1259 → 1429
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:875 → 1104
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1436 → 1558
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2082 → 2216
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:2666 → 2913
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    cd00096
    Location:2464 → 2468
    Ig; Ig strand B [structural motif]

  2. XM_042998401.1 → XP_042854335.1  kalirin isoform X3

    Conserved Domains (12) summary
    smart00150
    Location:1097 → 1197
    SPEC; Spectrin repeats
    cd11852
    Location:1611 → 1670
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2287 → 2345
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00410
    Location:2442 → 2528
    IG_like; Immunoglobulin like
    smart00516
    Location:23 → 161
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:2532 → 2623
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:1246 → 1416
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:862 → 1091
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1423 → 1545
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2069 → 2203
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:2653 → 2900
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    cd00096
    Location:2451 → 2455
    Ig; Ig strand B [structural motif]

  3. XM_042998403.1 → XP_042854337.1  kalirin isoform X5

    Conserved Domains (5) summary
    smart00150
    Location:1110 → 1210
    SPEC; Spectrin repeats
    smart00516
    Location:23 → 161
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1259 → 1429
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:875 → 1104
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1436 → 1558
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

  4. XM_042998404.1 → XP_042854338.1  kalirin isoform X6

    Conserved Domains (5) summary
    smart00150
    Location:1097 → 1197
    SPEC; Spectrin repeats
    smart00516
    Location:23 → 161
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1246 → 1416
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:862 → 1091
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1423 → 1545
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

  5. XM_015544797.2 → XP_015400283.2  kalirin isoform X2

    Conserved Domains (11) summary
    smart00150
    Location:1023 → 1123
    SPEC; Spectrin repeats
    cd11852
    Location:1537 → 1596
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2213 → 2271
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00409
    Location:2368 → 2454
    IG; Immunoglobulin
    cd00063
    Location:2458 → 2549
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:1172 → 1342
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:438 → 654
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1349 → 1471
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:1995 → 2129
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:2579 → 2826
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    cl15787
    Location:1 → 78
    SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...

  6. XM_042998402.1 → XP_042854336.1  kalirin isoform X4

    Conserved Domains (11) summary
    smart00150
    Location:824 → 924
    SPEC; Spectrin repeats
    cd11852
    Location:1338 → 1397
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2014 → 2072
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00410
    Location:2169 → 2255
    IG_like; Immunoglobulin like
    cd00063
    Location:2259 → 2350
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:973 → 1143
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:580 → 818
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1150 → 1272
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:1796 → 1930
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:2380 → 2627
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    cd00096
    Location:2178 → 2182
    Ig; Ig strand B [structural motif]

  7. XM_042998406.1 → XP_042854340.1  kalirin isoform X8

    UniProtKB/TrEMBL
    A0A8C9KYB3
    Conserved Domains (8) summary
    cd11853
    Location:628 → 686
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd00063
    Location:873 → 964
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd13241
    Location:411 → 545
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:994 → 1241
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:237 → 406
    RhoGEF; RhoGEF domain
    pfam07679
    Location:775 → 869
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:29 → 194
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cd00096
    Location:767 → 770
    Ig; Ig strand A [structural motif]

  8. XM_042998405.1 → XP_042854339.1  kalirin isoform X7

    UniProtKB/TrEMBL
    A0A8C9KYB3
    Conserved Domains (8) summary
    cd11853
    Location:629 → 687
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd00063
    Location:874 → 965
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd13241
    Location:411 → 545
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:995 → 1242
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:237 → 406
    RhoGEF; RhoGEF domain
    pfam07679
    Location:776 → 870
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:29 → 194
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cd00096
    Location:768 → 771
    Ig; Ig strand A [structural motif]

  9. XM_042998408.1 → XP_042854342.1  kalirin isoform X10

    Conserved Domains (4) summary
    cd11853
    Location:597 → 655
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd13241
    Location:379 → 513
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam00621
    Location:205 → 374
    RhoGEF; RhoGEF domain
    pfam16609
    Location:29 → 202
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  10. XM_042998410.1 → XP_042854344.1  kalirin isoform X12

    Conserved Domains (4) summary
    cd11853
    Location:596 → 654
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd13241
    Location:379 → 513
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam00621
    Location:205 → 374
    RhoGEF; RhoGEF domain
    pfam16609
    Location:29 → 202
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  11. XM_042998407.1 → XP_042854341.1  kalirin isoform X9

    Conserved Domains (4) summary
    cd11853
    Location:627 → 685
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd13241
    Location:410 → 544
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam00621
    Location:236 → 405
    RhoGEF; RhoGEF domain
    pfam16609
    Location:29 → 193
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  12. XM_042998409.1 → XP_042854343.1  kalirin isoform X11

    Conserved Domains (4) summary
    cd11853
    Location:596 → 654
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd13241
    Location:378 → 512
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam00621
    Location:204 → 373
    RhoGEF; RhoGEF domain
    pfam16609
    Location:29 → 201
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  13. XM_042998411.1 → XP_042854345.1  kalirin isoform X13

    Conserved Domains (4) summary
    cd11853
    Location:595 → 653
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd13241
    Location:378 → 512
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam00621
    Location:204 → 373
    RhoGEF; RhoGEF domain
    pfam16609
    Location:29 → 201
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
Nucleotide Protein
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