U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

DNAJA2 DnaJ heat shock protein family (Hsp40) member A2 [ Homo sapiens (human) ]

Gene ID: 10294, updated on 7-Apr-2024

Summary

Official Symbol
DNAJA2provided by HGNC
Official Full Name
DnaJ heat shock protein family (Hsp40) member A2provided by HGNC
Primary source
HGNC:HGNC:14884
See related
Ensembl:ENSG00000069345 MIM:611322; AllianceGenome:HGNC:14884
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DJ3; CPR3; DJA2; DNAJ; DNJ3; RDJ2; HIRIP4; PRO3015
Summary
The protein encoded by this gene belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate molecular chaperone activity by stimulating ATPase activity. DNAJ proteins may have up to 3 distinct domains: a conserved 70-amino acid J domain, usually at the N terminus; a glycine/phenylalanine (G/F)-rich region; and a cysteine-rich domain containing 4 motifs resembling a zinc finger domain. The product of this gene works as a cochaperone of Hsp70s in protein folding and mitochondrial protein import in vitro. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 26.8), heart (RPKM 23.4) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Location:
16q11.2
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (46955362..46973674, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (52752176..52770493, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (46989274..47007585, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:46877721-46878246 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:46878247-46878770 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10778 Neighboring gene Sharpr-MPRA regulatory region 14543 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10779 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:46903238-46903844 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:46903845-46904450 Neighboring gene creatine kinase B pseudogene 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:46917671-46918263 Neighboring gene Sharpr-MPRA regulatory region 10353 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:46931211-46931883 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:46933408-46934347 Neighboring gene small nucleolar RNA, C/D box 148 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7437 Neighboring gene glutamic--pyruvic transaminase 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10781 Neighboring gene Sharpr-MPRA regulatory region 12922 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:46963495-46964034 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:46964035-46964572 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:46993862-46994528 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:46999088-46999813 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7439 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7440 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7441 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7442 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7443 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10783 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10782 Neighboring gene DNAJA2 divergent transcript Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:47025988-47026488 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7444 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7445 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10784 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10785 Neighboring gene MPRA-validated peak2576 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:47112757-47113521 Neighboring gene neuropilin and tolloid like 2 Neighboring gene small nucleolar RNA U13

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of DnaJ (Hsp40) homolog, subfamily A, member 2 (DNAJA2) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif interacts with DNAJA2; interaction predicted to be relevant in protein folding and/or macromolecular structure assembly PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATPase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables Hsp70 protein binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-folding chaperone binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein-folding chaperone binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables unfolded protein binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in positive regulation of cell population proliferation TAS
Traceable Author Statement
more info
PubMed 
involved_in protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein refolding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to heat IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
dnaJ homolog subfamily A member 2
Names
DnaJ (Hsp40) homolog, subfamily A, member 2
HIRA interacting protein 4
cell cycle progression 3 protein
cell cycle progression restoration gene 3 protein
renal carcinoma antigen NY-REN-14

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005880.4NP_005871.1  dnaJ homolog subfamily A member 2

    See identical proteins and their annotated locations for NP_005871.1

    Status: REVIEWED

    Source sequence(s)
    AC018845, BC015809, BU677823, DB097731
    Consensus CDS
    CCDS10726.1
    UniProtKB/Swiss-Prot
    B2R7L7, O14711, O60884
    Related
    ENSP00000314030.5, ENST00000317089.10
    Conserved Domains (1) summary
    PTZ00037
    Location:4412
    PTZ00037; DnaJ_C chaperone protein; Provisional

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    46955362..46973674 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    52752176..52770493 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)