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Dnaja2 DnaJ heat shock protein family (Hsp40) member A2 [ Mus musculus (house mouse) ]

Gene ID: 56445, updated on 5-Mar-2024

Summary

Official Symbol
Dnaja2provided by MGI
Official Full Name
DnaJ heat shock protein family (Hsp40) member A2provided by MGI
Primary source
MGI:MGI:1931882
See related
Ensembl:ENSMUSG00000031701 AllianceGenome:MGI:1931882
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DNAJ; DNJ3; mDj3; Dnaj3; HIRIP4; PRO3015; 1500017M13Rik; 2010206B19Rik
Summary
Predicted to enable ATPase activator activity; chaperone binding activity; and unfolded protein binding activity. Predicted to be involved in protein refolding. Predicted to be located in nucleus. Predicted to be active in cytosol. Orthologous to human DNAJA2 (DnaJ heat shock protein family (Hsp40) member A2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 23.5), placenta adult (RPKM 23.2) and 28 other tissues See more
Orthologs
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Genomic context

Location:
8 C3; 8 41.61 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (86264262..86281990, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (85537633..85555361, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53446 Neighboring gene STARR-seq mESC enhancer starr_22160 Neighboring gene STARR-positive B cell enhancer ABC_E8255 Neighboring gene glutamic pyruvate transaminase (alanine aminotransferase) 2 Neighboring gene STARR-seq mESC enhancer starr_22166 Neighboring gene STARR-seq mESC enhancer starr_22168 Neighboring gene STARR-positive B cell enhancer ABC_E6669 Neighboring gene predicted gene, 51583 Neighboring gene STARR-seq mESC enhancer starr_22169 Neighboring gene predicted gene, 53447

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATPase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables Hsp70 protein binding IEA
Inferred from Electronic Annotation
more info
 
enables heat shock protein binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein-folding chaperone binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein-folding chaperone binding ISO
Inferred from Sequence Orthology
more info
 
enables unfolded protein binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
 
involved_in protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein refolding ISO
Inferred from Sequence Orthology
more info
 
involved_in response to heat IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
dnaJ homolog subfamily A member 2
Names
DNA J protein
DnaJ (Hsp40) homolog, subfamily A, member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019794.5NP_062768.1  dnaJ homolog subfamily A member 2

    See identical proteins and their annotated locations for NP_062768.1

    Status: VALIDATED

    Source sequence(s)
    AC122409, AC130533
    Consensus CDS
    CCDS22500.1
    UniProtKB/Swiss-Prot
    Q9QYJ0
    UniProtKB/TrEMBL
    Q3TFF0
    Related
    ENSMUSP00000034138.6, ENSMUST00000034138.7
    Conserved Domains (1) summary
    PTZ00037
    Location:4412
    PTZ00037; DnaJ_C chaperone protein; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    86264262..86281990 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)