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SPRY1 sprouty RTK signaling antagonist 1 [ Homo sapiens (human) ]

Gene ID: 10252, updated on 13-May-2022

Summary

Official Symbol
SPRY1provided by HGNC
Official Full Name
sprouty RTK signaling antagonist 1provided by HGNC
Primary source
HGNC:HGNC:11269
See related
Ensembl:ENSG00000164056 MIM:602465; AllianceGenome:HGNC:11269
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
hSPRY1
Summary
Involved in negative regulation of fibroblast growth factor receptor signaling pathway. Located in Golgi apparatus; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in fat (RPKM 30.2), gall bladder (RPKM 30.0) and 25 other tissues See more
Orthologs
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Genomic context

See SPRY1 in Genome Data Viewer
Location:
4q28.1
Exon count:
6
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (123396795..123403760)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (126700894..126707854)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (124317950..124324915)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 14026 Neighboring gene uncharacterized LOC124900774 Neighboring gene VISTA enhancer hs1582 Neighboring gene tRNA-Cys (anticodon GCA) 2-1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study identifies two novel genomic regions in irritable bowel syndrome.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif upregulates the expression of sprouty homolog 1 protein (SPRY1, antagonist of FGF signaling) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in animal organ development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in bud elongation involved in lung branching IEA
Inferred from Electronic Annotation
more info
 
involved_in epithelial to mesenchymal transition involved in cardiac fibroblast development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in establishment of mitotic spindle orientation IEA
Inferred from Electronic Annotation
more info
 
involved_in metanephros development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of MAP kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of epithelial to mesenchymal transition ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of fibroblast growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of fibroblast growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of lens fiber cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of neurotrophin TRK receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of transforming growth factor beta receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in organ induction IEA
Inferred from Electronic Annotation
more info
 
involved_in ureteric bud development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
protein sprouty homolog 1
Names
sprouty homolog 1, antagonist of FGF signaling
sprouty, Drosophila, homolog of, 1 (antagonist of FGF signaling)
spry-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001258038.2NP_001244967.1  protein sprouty homolog 1

    See identical proteins and their annotated locations for NP_001244967.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest variant. Variants 1-4 encode the same protein.
    Source sequence(s)
    AL602431, AY590694, CA447611, DA765300
    Consensus CDS
    CCDS3731.1
    UniProtKB/Swiss-Prot
    O43609
    Related
    ENSP00000498292.1, ENST00000651917.1
    Conserved Domains (1) summary
    pfam05210
    Location:187284
    Sprouty; Sprouty protein (Spry)
  2. NM_001258039.1NP_001244968.1  protein sprouty homolog 1

    See identical proteins and their annotated locations for NP_001244968.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate promoter, compared to variant 1. Variants 1-4 encode the same protein.
    Source sequence(s)
    AV692593, AY590694, CA447611, CN302060
    Consensus CDS
    CCDS3731.1
    UniProtKB/Swiss-Prot
    O43609
    Related
    ENSP00000480540.1, ENST00000622283.1
    Conserved Domains (1) summary
    pfam05210
    Location:187284
    Sprouty; Sprouty protein (Spry)
  3. NM_001375410.1NP_001362339.1  protein sprouty homolog 1

    Status: VALIDATED

    Source sequence(s)
    AC026402
    Conserved Domains (1) summary
    pfam05210
    Location:187284
    Sprouty; Sprouty protein (Spry)
  4. NM_005841.3NP_005832.1  protein sprouty homolog 1

    See identical proteins and their annotated locations for NP_005832.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate promoter, compared to variant 1. Variants 1-4 encode the same protein.
    Source sequence(s)
    BC063856, CA447611
    Consensus CDS
    CCDS3731.1
    UniProtKB/Swiss-Prot
    O43609
    Related
    ENSP00000377871.2, ENST00000394339.2
    Conserved Domains (1) summary
    pfam05210
    Location:187284
    Sprouty; Sprouty protein (Spry)
  5. NM_199327.3NP_955359.1  protein sprouty homolog 1

    See identical proteins and their annotated locations for NP_955359.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5'UTR, compared to variant 1. Variants 1-4 encode the same protein.
    Source sequence(s)
    AL602431, AY192146, AY590694, CA447611
    Consensus CDS
    CCDS3731.1
    UniProtKB/Swiss-Prot
    O43609
    Related
    ENSP00000343785.1, ENST00000339241.1
    Conserved Domains (1) summary
    pfam05210
    Location:187284
    Sprouty; Sprouty protein (Spry)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    123396795..123403760
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047449492.1XP_047305448.1  protein sprouty homolog 1 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    126700894..126707854
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)