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SPRY1 sprouty RTK signaling antagonist 1 [ Homo sapiens (human) ]

Gene ID: 10252, updated on 3-Jun-2018
Official Symbol
SPRY1provided by HGNC
Official Full Name
sprouty RTK signaling antagonist 1provided by HGNC
Primary source
HGNC:HGNC:11269
See related
Ensembl:ENSG00000164056 MIM:602465; Vega:OTTHUMG00000133071
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
hSPRY1
Expression
Ubiquitous expression in fat (RPKM 30.2), gall bladder (RPKM 30.0) and 25 other tissues See more
Orthologs
See SPRY1 in Genome Data Viewer
Location:
4q28.1
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 4 NC_000004.12 (123396791..123403760)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (124317946..124324915)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene spermatogenesis associated 5 Neighboring gene coilin pseudogene 2 Neighboring gene uncharacterized LOC105377404 Neighboring gene VISTA enhancer hs1582 Neighboring gene transfer RNA-Cys (GCA) 2-1

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association study identifies two novel genomic regions in irritable bowel syndrome.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif upregulates the expression of sprouty homolog 1 protein (SPRY1, antagonist of FGF signaling) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

  • EGFR downregulation, organism-specific biosystem (from REACTOME)
    EGFR downregulation, organism-specific biosystemRegulation of receptor tyrosine kinase (RTK) activity is implicated in the control of almost all cellular functions. One of the best understood RTKs is epidermal growth factor receptor (EGFR). Growth...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by EGFR, organism-specific biosystem (from REACTOME)
    Signaling by EGFR, organism-specific biosystemThe epidermal growth factor receptor (EGFR) is one member of the ERBB family of transmembrane glycoprotein tyrosine receptor kinases (RTK). Binding of EGFR to its ligands induces conformational chang...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
animal organ development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
bud elongation involved in lung branching IEA
Inferred from Electronic Annotation
more info
 
epithelial to mesenchymal transition involved in cardiac fibroblast development ISS
Inferred from Sequence or Structural Similarity
more info
 
establishment of mitotic spindle orientation IEA
Inferred from Electronic Annotation
more info
 
metanephros development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of MAP kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of MAP kinase activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of Ras protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of epidermal growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
negative regulation of fibroblast growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of fibroblast growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of neurotrophin TRK receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
organ induction IEA
Inferred from Electronic Annotation
more info
 
ureteric bud development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
protein sprouty homolog 1
Names
sprouty homolog 1, antagonist of FGF signaling
sprouty, Drosophila, homolog of, 1 (antagonist of FGF signaling)
spry-1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001258038.1NP_001244967.1  protein sprouty homolog 1

    See identical proteins and their annotated locations for NP_001244967.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest variant. Variants 1-4 encode the same protein.
    Source sequence(s)
    AL602431, AY590694, CA447611, DA765300
    Consensus CDS
    CCDS3731.1
    UniProtKB/Swiss-Prot
    O43609
    Related
    ENSP00000481675.1, ENST00000610581.4
    Conserved Domains (1) summary
    pfam05210
    Location:187284
    Sprouty; Sprouty protein (Spry)
  2. NM_001258039.1NP_001244968.1  protein sprouty homolog 1

    See identical proteins and their annotated locations for NP_001244968.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate promoter, compared to variant 1. Variants 1-4 encode the same protein.
    Source sequence(s)
    AV692593, AY590694, CA447611, CN302060
    Consensus CDS
    CCDS3731.1
    UniProtKB/Swiss-Prot
    O43609
    Related
    ENSP00000480540.1, ENST00000622283.1
    Conserved Domains (1) summary
    pfam05210
    Location:187284
    Sprouty; Sprouty protein (Spry)
  3. NM_005841.2NP_005832.1  protein sprouty homolog 1

    See identical proteins and their annotated locations for NP_005832.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate promoter, compared to variant 1. Variants 1-4 encode the same protein.
    Source sequence(s)
    BC063856, CA447611, DB250100
    Consensus CDS
    CCDS3731.1
    UniProtKB/Swiss-Prot
    O43609
    Related
    ENSP00000377871.2, OTTHUMP00000164086, ENST00000394339.2, OTTHUMT00000256711
    Conserved Domains (1) summary
    pfam05210
    Location:187284
    Sprouty; Sprouty protein (Spry)
  4. NM_199327.2NP_955359.1  protein sprouty homolog 1

    See identical proteins and their annotated locations for NP_955359.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5'UTR, compared to variant 1. Variants 1-4 encode the same protein.
    Source sequence(s)
    AL602431, AY192146, AY590694, CA447611
    Consensus CDS
    CCDS3731.1
    UniProtKB/Swiss-Prot
    O43609
    Related
    ENSP00000343785.1, OTTHUMP00000219789, ENST00000339241.1, OTTHUMT00000363944
    Conserved Domains (1) summary
    pfam05210
    Location:187284
    Sprouty; Sprouty protein (Spry)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p12 Primary Assembly

    Range
    123396791..123403760
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005262686.1XP_005262743.1  protein sprouty homolog 1 isoform X1

    See identical proteins and their annotated locations for XP_005262743.1

    UniProtKB/Swiss-Prot
    O43609
    Conserved Domains (1) summary
    pfam05210
    Location:187284
    Sprouty; Sprouty protein (Spry)
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