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Spry1 sprouty RTK signaling antagonist 1 [ Mus musculus (house mouse) ]

Gene ID: 24063, updated on 8-Nov-2022

Summary

Official Symbol
Spry1provided by MGI
Official Full Name
sprouty RTK signaling antagonist 1provided by MGI
Primary source
MGI:MGI:1345139
See related
Ensembl:ENSMUSG00000037211 AllianceGenome:MGI:1345139
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
spry-1; sprouty1
Summary
Involved in negative regulation of cell differentiation and negative regulation of signal transduction. Acts upstream of or within several processes, including bud elongation involved in lung branching; kidney development; and negative regulation of signal transduction. Predicted to be located in Golgi apparatus and nucleoplasm. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; branchial arch; embryo ectoderm; limb; and sensory organ. Orthologous to human SPRY1 (sprouty RTK signaling antagonist 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lung adult (RPKM 52.2), genital fat pad adult (RPKM 23.9) and 24 other tissues See more
Orthologs
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Genomic context

See Spry1 in Genome Data Viewer
Location:
3; 3 B
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (37694096..37698748)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (37639947..37644599)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36412 Neighboring gene RIKEN cDNA 4930594O21 gene Neighboring gene PRELI domain containing 1 pseudogene Neighboring gene predicted gene 42922 Neighboring gene predicted gene, 46799 Neighboring gene predicted gene, 42211

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (7)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of ERK1 and ERK2 cascade IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in animal organ development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within bud elongation involved in lung branching IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in epithelial to mesenchymal transition involved in cardiac fibroblast development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within establishment of mitotic spindle orientation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within metanephros development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of ERK1 and ERK2 cascade IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of MAP kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within negative regulation of MAP kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within negative regulation of Ras protein signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of epithelial to mesenchymal transition IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of fibroblast growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within negative regulation of fibroblast growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of fibroblast growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of lens fiber cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of neurotrophin TRK receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within organ induction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within ureteric bud development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within ureteric bud development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protein sprouty homolog 1
Names
inhibitor of receptor tyrosine kinases
sprouty homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001305440.1NP_001292369.1  protein sprouty homolog 1

    See identical proteins and their annotated locations for NP_001292369.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4, encode the same protein.
    Source sequence(s)
    AC110508, AK140405, AV377285, BC051977
    Consensus CDS
    CCDS17322.1
    UniProtKB/Swiss-Prot
    Q9QXV9
    UniProtKB/TrEMBL
    A0A6P7QXE7, Q53ZU1
    Related
    ENSMUSP00000103744.2, ENSMUST00000108109.8
    Conserved Domains (1) summary
    pfam05210
    Location:181278
    Sprouty; Sprouty protein (Spry)
  2. NM_001305441.1NP_001292370.1  protein sprouty homolog 1

    See identical proteins and their annotated locations for NP_001292370.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an exon in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4, encode the same protein.
    Source sequence(s)
    AC110508, AK140405, AV377285, BC051977
    Consensus CDS
    CCDS17322.1
    UniProtKB/Swiss-Prot
    Q9QXV9
    UniProtKB/TrEMBL
    A0A6P7QXE7, Q53ZU1
    Conserved Domains (1) summary
    pfam05210
    Location:181278
    Sprouty; Sprouty protein (Spry)
  3. NM_001305442.1NP_001292371.1  protein sprouty homolog 1

    See identical proteins and their annotated locations for NP_001292371.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site and lacks an exon in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4, encode the same protein.
    Source sequence(s)
    AC110508, AK140405, AV377285, BC051977
    Consensus CDS
    CCDS17322.1
    UniProtKB/Swiss-Prot
    Q9QXV9
    UniProtKB/TrEMBL
    A0A6P7QXE7, Q53ZU1
    Conserved Domains (1) summary
    pfam05210
    Location:181278
    Sprouty; Sprouty protein (Spry)
  4. NM_011896.3NP_036026.1  protein sprouty homolog 1

    See identical proteins and their annotated locations for NP_036026.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3, and 4, encode the same protein.
    Source sequence(s)
    AC110508, AK140405, AV377285, BC051977
    Consensus CDS
    CCDS17322.1
    UniProtKB/Swiss-Prot
    Q9QXV9
    UniProtKB/TrEMBL
    A0A6P7QXE7, Q53ZU1
    Related
    ENSMUSP00000049292.2, ENSMUST00000038569.8
    Conserved Domains (1) summary
    pfam05210
    Location:181278
    Sprouty; Sprouty protein (Spry)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    37694096..37698748
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)