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TIMM17B translocase of inner mitochondrial membrane 17B [ Homo sapiens (human) ]

Gene ID: 10245, updated on 7-Jun-2020

Summary

Official Symbol
TIMM17Bprovided by HGNC
Official Full Name
translocase of inner mitochondrial membrane 17Bprovided by HGNC
Primary source
HGNC:HGNC:17310
See related
Ensembl:ENSG00000126768 MIM:300249
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
JM3; TIM17B; DXS9822
Summary
This gene encodes a multipass transmembrane protein that forms an integral component of the mitochondrial translocase TIM23 complex. This complex facilitates the transport of mitochondrial proteins from the cytosol across the mitochondrial inner membrane and into the mitochondrion. There is a pseudogene for this gene on chromosome 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Expression
Ubiquitous expression in heart (RPKM 15.4), prostate (RPKM 13.6) and 25 other tissues See more
Orthologs

Genomic context

See TIMM17B in Genome Data Viewer
Location:
Xp11.23
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (48893447..48898143, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (48750730..48755489, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ES cell expressed Ras Neighboring gene proprotein convertase subtilisin/kexin type 1 inhibitor Neighboring gene polyglutamine binding protein 1 Neighboring gene solute carrier family 35 member A2 Neighboring gene Pim-2 proto-oncogene, serine/threonine kinase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of translocase of inner mitochondrial membrane 17 homolog B (TIMM17B) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
P-P-bond-hydrolysis-driven protein transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
protein import into mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein targeting to mitochondrion TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
mitochondrial import inner membrane translocase subunit Tim17-B
Names
inner mitochondrial membrane preprotein translocase
translocase of inner mitochondrial membrane 17 homolog B

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_015968.2 RefSeqGene

    Range
    5007..9701
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001167947.2NP_001161419.1  mitochondrial import inner membrane translocase subunit Tim17-B isoform 1

    See identical proteins and their annotated locations for NP_001161419.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1, also known as hTim17a).
    Source sequence(s)
    AF034790, AJ005895, CA421979, CB993524
    Consensus CDS
    CCDS55411.1
    UniProtKB/Swiss-Prot
    O60830
    Related
    ENSP00000379999.3, ENST00000396779.7
    Conserved Domains (1) summary
    cl02381
    Location:1221
    Tim17; Tim17/Tim22/Tim23/Pmp24 family
  2. NM_005834.5NP_005825.1  mitochondrial import inner membrane translocase subunit Tim17-B isoform 2

    See identical proteins and their annotated locations for NP_005825.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2, also known as hTim17b) is shorter than isoform 1.
    Source sequence(s)
    AF034790, AJ005895
    Consensus CDS
    CCDS14308.1
    UniProtKB/Swiss-Prot
    O60830
    Related
    ENSP00000365766.3, ENST00000376582.7
    Conserved Domains (1) summary
    cl02381
    Location:1171
    Tim17; Tim17/Tim22/Tim23/Pmp24 family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    48893447..48898143 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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