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Timm17b translocase of inner mitochondrial membrane 17b [ Mus musculus (house mouse) ]

Gene ID: 21855, updated on 11-Apr-2024

Summary

Official Symbol
Timm17bprovided by MGI
Official Full Name
translocase of inner mitochondrial membrane 17bprovided by MGI
Primary source
MGI:MGI:1343176
See related
Ensembl:ENSMUSG00000031158 AllianceGenome:MGI:1343176
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sfc3; 17kDa; mTim17b
Summary
Predicted to contribute to protein transmembrane transporter activity. Predicted to be involved in protein import into mitochondrial matrix. Predicted to act upstream of or within protein transport. Located in mitochondrial inner membrane. Orthologous to human TIMM17B (translocase of inner mitochondrial membrane 17B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 27.9), ovary adult (RPKM 20.0) and 28 other tissues See more
Orthologs
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Genomic context

Location:
X A1.1; X 3.56 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (7765575..7773891)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (7899336..7907652)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene solute carrier family 35 (UDP-galactose transporter), member A2 Neighboring gene STARR-positive B cell enhancer ABC_E7684 Neighboring gene polyglutamine binding protein 1 Neighboring gene proprotein convertase subtilisin/kexin type 1 inhibitor Neighboring gene STARR-seq mESC enhancer starr_46677 Neighboring gene ES cell-expressed Ras Neighboring gene histone deacetylase 6 Neighboring gene STARR-seq mESC enhancer starr_46678 Neighboring gene STARR-seq mESC enhancer starr_46679

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
mitochondrial import inner membrane translocase subunit Tim17-B
Names
translocator of inner mitochondrial membrane 17 kDa, b
translocator of inner mitochondrial membrane 17b
translocator of inner mitochondrial membrane b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001313693.1NP_001300622.1  mitochondrial import inner membrane translocase subunit Tim17-B isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate first exon in place of that of variant 1. This difference causes translation initiation at a downstream AUG and results in an isoform (2) with a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AK049584, AL670169, W46058
    UniProtKB/TrEMBL
    Q3UBR8
    Conserved Domains (1) summary
    cl02381
    Location:1149
    Tim17; Tim17/Tim22/Tim23/Pmp24 family
  2. NM_011591.5NP_035721.1  mitochondrial import inner membrane translocase subunit Tim17-B isoform 1

    See identical proteins and their annotated locations for NP_035721.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK049584, AL670169, AL671978
    Consensus CDS
    CCDS29978.1
    UniProtKB/Swiss-Prot
    Q9Z0V7
    UniProtKB/TrEMBL
    Q3UBR8, Q545H3
    Related
    ENSMUSP00000033498.4, ENSMUST00000033498.11
    Conserved Domains (1) summary
    cl02381
    Location:1171
    Tim17; Tim17/Tim22/Tim23/Pmp24 family

RNA

  1. NR_132589.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK049584, AL670169, AL671978, BY294049

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    7765575..7773891
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)