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SLC35B1 solute carrier family 35 member B1 [ Homo sapiens (human) ]

Gene ID: 10237, updated on 7-Jun-2020

Summary

Official Symbol
SLC35B1provided by HGNC
Official Full Name
solute carrier family 35 member B1provided by HGNC
Primary source
HGNC:HGNC:20798
See related
Ensembl:ENSG00000121073 MIM:610790
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UGTREL1
Summary
This gene encodes a nucleotide sugar transporter which is a member of solute carrier family 35. The transporters in this family are highly conserved hydrophobic proteins with multiple transmembrane domains. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]
Expression
Ubiquitous expression in thyroid (RPKM 24.3), duodenum (RPKM 18.7) and 25 other tissues See more
Orthologs

Genomic context

See SLC35B1 in Genome Data Viewer
Location:
17q21.33
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (49700943..49708173, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (47778296..47785313, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene neurexophilin 3 Neighboring gene uncharacterized LOC107984999 Neighboring gene speckle type BTB/POZ protein Neighboring gene family with sequence similarity 117 member A Neighboring gene signal recognition particle 14 pseudogene 3 Neighboring gene lysine acetyltransferase 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of solute carrier family 35, member B1 (SLC35B1) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
UDP-galactose transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
UDP-glucose transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
UDP-galactose transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
UDP-glucose transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
carbohydrate transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular membrane-bounded organelle TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
solute carrier family 35 member B1
Names
UDP-galactose transporter related
UDP-galactose transporter-related protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278784.2NP_001265713.1  solute carrier family 35 member B1 isoform 2

    See identical proteins and their annotated locations for NP_001265713.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' coding region and initiates translation at downstream start codon compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC015795, AI252816, AU309730, CX164572
    UniProtKB/TrEMBL
    D3DTX1
    Conserved Domains (2) summary
    pfam08449
    Location:18242
    UAA; UAA transporter family
    cl23754
    Location:138242
    EamA; EamA-like transporter family
  2. NM_005827.4NP_005818.3  solute carrier family 35 member B1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
    Source sequence(s)
    AC015795, AI252816, AU099388, BM476321, D87989
    Consensus CDS
    CCDS11552.2
    Related
    ENSP00000240333.8, ENST00000240333.12
    Conserved Domains (1) summary
    pfam08449
    Location:16309
    UAA; UAA transporter family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    49700943..49708173 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011524180.2XP_011522482.1  solute carrier family 35 member B1 isoform X3

    See identical proteins and their annotated locations for XP_011522482.1

    UniProtKB/TrEMBL
    D3DTX1
    Conserved Domains (2) summary
    pfam08449
    Location:18242
    UAA; UAA transporter family
    cl23754
    Location:138242
    EamA; EamA-like transporter family
  2. XM_005256929.3XP_005256986.1  solute carrier family 35 member B1 isoform X3

    See identical proteins and their annotated locations for XP_005256986.1

    UniProtKB/TrEMBL
    D3DTX1
    Related
    ENSP00000423323.1, ENST00000503334.5
    Conserved Domains (2) summary
    pfam08449
    Location:18242
    UAA; UAA transporter family
    cl23754
    Location:138242
    EamA; EamA-like transporter family
  3. XM_006721632.3XP_006721695.1  solute carrier family 35 member B1 isoform X1

    Conserved Domains (2) summary
    pfam08449
    Location:53380
    UAA; UAA transporter family
    cl23754
    Location:276380
    EamA; EamA-like transporter family
  4. XM_011524179.2XP_011522481.1  solute carrier family 35 member B1 isoform X2

    Conserved Domains (2) summary
    pfam08449
    Location:53303
    UAA; UAA transporter family
    cl23754
    Location:199303
    EamA; EamA-like transporter family
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