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TRIB1 tribbles pseudokinase 1 [ Homo sapiens (human) ]

Gene ID: 10221, updated on 5-Aug-2022

Summary

Official Symbol
TRIB1provided by HGNC
Official Full Name
tribbles pseudokinase 1provided by HGNC
Primary source
HGNC:HGNC:16891
See related
Ensembl:ENSG00000173334 MIM:609461; AllianceGenome:HGNC:16891
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C8FW; GIG2; TRB1; GIG-2; SKIP1; TRB-1
Summary
Enables mitogen-activated protein kinase kinase binding activity and protein kinase inhibitor activity. Involved in several processes, including JNK cascade; negative regulation of lipopolysaccharide-mediated signaling pathway; and regulation of protein kinase activity. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bone marrow (RPKM 87.7), liver (RPKM 53.0) and 20 other tissues See more
Orthologs
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Genomic context

See TRIB1 in Genome Data Viewer
Location:
8q24.13
Exon count:
4
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (125430358..125438403)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (126563804..126571849)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (126442600..126450645)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase Neighboring gene Sharpr-MPRA regulatory region 6874 Neighboring gene Sharpr-MPRA regulatory region 8491 Neighboring gene Sharpr-MPRA regulatory region 8664 Neighboring gene long intergenic non-protein coding RNA 2964

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium.
EBI GWAS Catalog
A genome wide association study identifies common variants associated with lipid levels in the Chinese population.
EBI GWAS Catalog
Amerindian-specific regions under positive selection harbour new lipid variants in Latinos.
EBI GWAS Catalog
Biological, clinical and population relevance of 95 loci for blood lipids.
EBI GWAS Catalog
Common variants at 30 loci contribute to polygenic dyslipidemia.
EBI GWAS Catalog
Discovery and refinement of loci associated with lipid levels.
EBI GWAS Catalog
Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis.
EBI GWAS Catalog
Genetic variants influencing circulating lipid levels and risk of coronary artery disease.
EBI GWAS Catalog
Genome-wide association of lipid-lowering response to statins in combined study populations.
EBI GWAS Catalog
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
EBI GWAS Catalog
Genome-wide association study of hematological and biochemical traits in a Japanese population.
EBI GWAS Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
EBI GWAS Catalog
Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.
EBI GWAS Catalog
Newly identified loci that influence lipid concentrations and risk of coronary artery disease.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.
EBI GWAS Catalog
Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NOT enables ATP binding TAS
Traceable Author Statement
more info
PubMed 
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables mitogen-activated protein kinase kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables mitogen-activated protein kinase kinase binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
NOT enables protein kinase activity TAS
Traceable Author Statement
more info
PubMed 
enables protein kinase inhibitor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables ubiquitin protein ligase binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables ubiquitin-protein transferase regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
involved_in JNK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in negative regulation of lipopolysaccharide-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of neutrophil differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of smooth muscle cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of eosinophil differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of macrophage differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
NOT involved_in protein phosphorylation TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of MAP kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of MAP kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to lipopolysaccharide ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
tribbles homolog 1
Names
G-protein-coupled receptor induced protein
G-protein-coupled receptor-induced gene 2 protein
G-protein-coupled receptor-induced protein 2
phosphoprotein regulated by mitogenic pathways
tribbles-like protein 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282985.2NP_001269914.1  tribbles homolog 1 isoform 2

    See identical proteins and their annotated locations for NP_001269914.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC091114, BC012441, DA686993
    Consensus CDS
    CCDS64971.1
    UniProtKB/Swiss-Prot
    Q96RU8
    Related
    ENSP00000429063.1, ENST00000520847.1
    Conserved Domains (2) summary
    smart00220
    Location:1172
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:1172
    PKc_like; Protein Kinases, catalytic domain
  2. NM_025195.4NP_079471.1  tribbles homolog 1 isoform 1

    See identical proteins and their annotated locations for NP_079471.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript nd encodes the longer isoform (1).
    Source sequence(s)
    AC091114, AL832388, BC012441
    Consensus CDS
    CCDS6357.1
    UniProtKB/Swiss-Prot
    Q96RU8, Q9H2Y8
    Related
    ENSP00000312150.3, ENST00000311922.4
    Conserved Domains (1) summary
    cd14023
    Location:97338
    PK_TRB1; Pseudokinase domain of Tribbles Homolog 1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    125430358..125438403
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    126563804..126571849
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)