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TRIB1 tribbles pseudokinase 1 [ Homo sapiens (human) ]

Gene ID: 10221, updated on 7-Dec-2018

Summary

Official Symbol
TRIB1provided by HGNC
Official Full Name
tribbles pseudokinase 1provided by HGNC
Primary source
HGNC:HGNC:16891
See related
Ensembl:ENSG00000173334 MIM:609461
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C8FW; GIG2; TRB1; GIG-2; SKIP1; TRB-1
Expression
Broad expression in bone marrow (RPKM 87.7), liver (RPKM 53.0) and 20 other tissues See more
Orthologs

Genomic context

See TRIB1 in Genome Data Viewer
Location:
8q24.13
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 8 NC_000008.11 (125430290..125438405)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (126442563..126450647)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase Neighboring gene HNF1 motif-containing MPRA enhancer 31 Neighboring gene RNA, 7SL, cytoplasmic 329, pseudogene Neighboring gene uncharacterized LOC105375746 Neighboring gene uncharacterized LOC105375747

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium.
NHGRI GWA Catalog
A genome wide association study identifies common variants associated with lipid levels in the Chinese population.
NHGRI GWA Catalog
Amerindian-specific regions under positive selection harbour new lipid variants in Latinos.
NHGRI GWA Catalog
Biological, clinical and population relevance of 95 loci for blood lipids.
NHGRI GWA Catalog
Common variants at 30 loci contribute to polygenic dyslipidemia.
NHGRI GWA Catalog
Discovery and refinement of loci associated with lipid levels.
NHGRI GWA Catalog
Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis.
NHGRI GWA Catalog
Genetic variants influencing circulating lipid levels and risk of coronary artery disease.
NHGRI GWA Catalog
Genome-wide association of lipid-lowering response to statins in combined study populations.
NHGRI GWA Catalog
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
NHGRI GWA Catalog
Genome-wide association study of hematological and biochemical traits in a Japanese population.
NHGRI GWA Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog
Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.
NHGRI GWA Catalog
Newly identified loci that influence lipid concentrations and risk of coronary artery disease.
NHGRI GWA Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.
NHGRI GWA Catalog
Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NOT ATP binding TAS
Traceable Author Statement
more info
PubMed 
mitogen-activated protein kinase kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitogen-activated protein kinase kinase binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
NOT protein kinase activity TAS
Traceable Author Statement
more info
PubMed 
protein kinase inhibitor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
ubiquitin-protein transferase regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
JNK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of lipopolysaccharide-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of neutrophil differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of smooth muscle cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of eosinophil differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of macrophage differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
NOT protein phosphorylation TAS
Traceable Author Statement
more info
PubMed 
regulation of MAP kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of MAP kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to lipopolysaccharide ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
tribbles homolog 1
Names
G-protein-coupled receptor induced protein
G-protein-coupled receptor-induced gene 2 protein
G-protein-coupled receptor-induced protein 2
phosphoprotein regulated by mitogenic pathways
tribbles-like protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282985.1NP_001269914.1  tribbles homolog 1 isoform 2

    See identical proteins and their annotated locations for NP_001269914.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC091114, BC012441, DA686993
    Consensus CDS
    CCDS64971.1
    UniProtKB/Swiss-Prot
    Q96RU8
    Related
    ENSP00000429063.1, ENST00000520847.1
    Conserved Domains (2) summary
    smart00220
    Location:1172
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:1172
    PKc_like; Protein Kinases, catalytic domain
  2. NM_025195.4NP_079471.1  tribbles homolog 1 isoform 1

    See identical proteins and their annotated locations for NP_079471.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript nd encodes the longer isoform (1).
    Source sequence(s)
    AC091114, AL832388, BC012441
    Consensus CDS
    CCDS6357.1
    UniProtKB/Swiss-Prot
    Q96RU8
    Related
    ENSP00000312150.3, ENST00000311922.3
    Conserved Domains (1) summary
    cd14023
    Location:97338
    PK_TRB1; Pseudokinase domain of Tribbles Homolog 1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p12 Primary Assembly

    Range
    125430290..125438405
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_428373.3 RNA Sequence

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