U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Trib1 tribbles pseudokinase 1 [ Mus musculus (house mouse) ]

Gene ID: 211770, updated on 26-Sep-2022

Summary

Official Symbol
Trib1provided by MGI
Official Full Name
tribbles pseudokinase 1provided by MGI
Primary source
MGI:MGI:2443397
See related
Ensembl:ENSMUSG00000032501 AllianceGenome:MGI:2443397
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Trb1; TRB-1; A530090O15Rik
Summary
Enables ubiquitin protein ligase binding activity and ubiquitin-protein transferase regulator activity. Involved in several processes, including negative regulation of DNA-binding transcription factor activity; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; and regulation of myeloid leukocyte differentiation. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart valve; and integumental system. Orthologous to human TRIB1 (tribbles pseudokinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in colon adult (RPKM 28.7), small intestine adult (RPKM 14.1) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Trib1 in Genome Data Viewer
Location:
15; 15 D1
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (59520503..59528948)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (59648654..59657099)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase Neighboring gene predicted gene, 36677 Neighboring gene predicted gene, 20150 Neighboring gene predicted gene, 19510

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (7)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in JNK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of lipopolysaccharide-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neutrophil differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of eosinophil differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of macrophage differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of ubiquitin-protein transferase activity IC
Inferred by Curator
more info
PubMed 
NOT involved_in protein phosphorylation TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of MAP kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_144549.4NP_653132.1  tribbles homolog 1

    See identical proteins and their annotated locations for NP_653132.1

    Status: PROVISIONAL

    Source sequence(s)
    AC161172
    Consensus CDS
    CCDS27499.1
    UniProtKB/Swiss-Prot
    Q8K4K4, Q91W04
    UniProtKB/TrEMBL
    A0A8C6H676
    Related
    ENSMUSP00000068834.7, ENSMUST00000067543.8
    Conserved Domains (2) summary
    smart00220
    Location:105338
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14023
    Location:97338
    PK_TRB1; Pseudokinase domain of Tribbles Homolog 1

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    59520503..59528948
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)