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KIT KIT proto-oncogene, receptor tyrosine kinase [ Macaca fascicularis (crab-eating macaque) ]

Gene ID: 102137242, updated on 12-Jun-2024

Summary

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Gene symbol
KIT
Gene description
KIT proto-oncogene, receptor tyrosine kinase
See related
Ensembl:ENSMFAG00000041033
Gene type
protein coding
RefSeq status
MODEL
Organism
Macaca fascicularis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 5
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_05 current T2T-MFA8v1.0 (GCF_037993035.1) 5 NC_088379.1 (79157707..79247225, complement)
102 previous assembly MFA1912RKSv2 (GCF_012559485.2) 5 NC_052259.1 (78792706..78881805, complement)

Chromosome 5 - NC_088379.1Genomic Context describing neighboring genes Neighboring gene kinase insert domain receptor Neighboring gene large ribosomal subunit protein eL38-like Neighboring gene uncharacterized LOC123573512 Neighboring gene uncharacterized LOC135970798

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cytokine binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables growth factor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in B cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in Fc receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in Kit signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in hematopoietic progenitor cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of MAP kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of receptor signaling pathway via JAK-STAT IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
mast/stem cell growth factor receptor Kit
Names
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_037993035.1-RS_2024_05

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference T2T-MFA8v1.0

Genomic

  1. NC_088379.1 Reference T2T-MFA8v1.0

    Range
    79157707..79247225 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015450467.3 → XP_015305953.1  mast/stem cell growth factor receptor Kit isoform X8

    UniProtKB/TrEMBL
    G7P5T3
    Conserved Domains (6) summary
    cd00096
    Location:426 → 505
    Ig; Immunoglobulin domain
    cd05860
    Location:311 → 411
    Ig4_SCFR; Fourth immunoglobulin (Ig)-like domain of stem cell factor receptor (SCFR)
    smart00410
    Location:220 → 307
    IG_like; Immunoglobulin like
    cd05104
    Location:549 → 923
    PTKc_Kit; Catalytic domain of the Protein Tyrosine Kinase, Kit
    pfam00047
    Location:216 → 305
    ig; Immunoglobulin domain
    pfam07714
    Location:585 → 919
    Pkinase_Tyr; Protein tyrosine kinase

  2. XM_005555275.4 → XP_005555332.1  mast/stem cell growth factor receptor Kit isoform X6

    See identical proteins and their annotated locations for XP_005555332.1

    UniProtKB/TrEMBL
    G7P5T3
    Related
    ENSMFAP00000007152.1
    Conserved Domains (6) summary
    cd00096
    Location:426 → 505
    Ig; Immunoglobulin domain
    cd05860
    Location:311 → 411
    Ig4_SCFR; Fourth immunoglobulin (Ig)-like domain of stem cell factor receptor (SCFR)
    smart00410
    Location:220 → 307
    IG_like; Immunoglobulin like
    cd05104
    Location:549 → 924
    PTKc_Kit; Catalytic domain of the Protein Tyrosine Kinase, Kit
    pfam00047
    Location:216 → 305
    ig; Immunoglobulin domain
    pfam07714
    Location:585 → 920
    Pkinase_Tyr; Protein tyrosine kinase

  3. XM_045392612.2 → XP_045248547.1  mast/stem cell growth factor receptor Kit isoform X4

    UniProtKB/TrEMBL
    G7P5T3

  4. XM_005555273.4 → XP_005555330.1  mast/stem cell growth factor receptor Kit isoform X2

    See identical proteins and their annotated locations for XP_005555330.1

    UniProtKB/TrEMBL
    A0A2K5U4C5, G7P5T3
    Conserved Domains (6) summary
    cd00096
    Location:426 → 505
    Ig; Immunoglobulin domain
    cd05860
    Location:311 → 411
    Ig4_SCFR; Fourth immunoglobulin (Ig)-like domain of stem cell factor receptor (SCFR)
    smart00410
    Location:220 → 307
    IG_like; Immunoglobulin like
    cd05104
    Location:553 → 928
    PTKc_Kit; Catalytic domain of the Protein Tyrosine Kinase, Kit
    pfam00047
    Location:216 → 305
    ig; Immunoglobulin domain
    pfam07714
    Location:589 → 924
    Pkinase_Tyr; Protein tyrosine kinase

  5. XM_045392614.2 → XP_045248549.1  mast/stem cell growth factor receptor Kit isoform X7

    UniProtKB/TrEMBL
    G7P5T3

  6. XM_015450466.3 → XP_015305952.1  mast/stem cell growth factor receptor Kit isoform X5

    UniProtKB/TrEMBL
    G7P5T3
    Conserved Domains (6) summary
    cd00096
    Location:427 → 506
    Ig; Immunoglobulin domain
    cd05860
    Location:312 → 412
    Ig4_SCFR; Fourth immunoglobulin (Ig)-like domain of stem cell factor receptor (SCFR)
    smart00410
    Location:220 → 308
    IG_like; Immunoglobulin like
    cd05104
    Location:550 → 925
    PTKc_Kit; Catalytic domain of the Protein Tyrosine Kinase, Kit
    pfam00047
    Location:216 → 306
    ig; Immunoglobulin domain
    pfam07714
    Location:586 → 921
    Pkinase_Tyr; Protein tyrosine kinase

  7. XM_005555274.4 → XP_005555331.1  mast/stem cell growth factor receptor Kit isoform X3

    UniProtKB/TrEMBL
    G7P5T3
    Conserved Domains (6) summary
    cd00096
    Location:427 → 506
    Ig; Immunoglobulin domain
    cd05860
    Location:312 → 412
    Ig4_SCFR; Fourth immunoglobulin (Ig)-like domain of stem cell factor receptor (SCFR)
    smart00410
    Location:220 → 308
    IG_like; Immunoglobulin like
    cd05104
    Location:554 → 928
    PTKc_Kit; Catalytic domain of the Protein Tyrosine Kinase, Kit
    pfam00047
    Location:216 → 306
    ig; Immunoglobulin domain
    pfam07714
    Location:590 → 924
    Pkinase_Tyr; Protein tyrosine kinase

  8. XM_005555272.4 → XP_005555329.1  mast/stem cell growth factor receptor Kit isoform X1

    UniProtKB/TrEMBL
    G7P5T3
    Conserved Domains (6) summary
    cd00096
    Location:427 → 506
    Ig; Immunoglobulin domain
    cd05860
    Location:312 → 412
    Ig4_SCFR; Fourth immunoglobulin (Ig)-like domain of stem cell factor receptor (SCFR)
    smart00410
    Location:220 → 308
    IG_like; Immunoglobulin like
    cd05104
    Location:554 → 929
    PTKc_Kit; Catalytic domain of the Protein Tyrosine Kinase, Kit
    pfam00047
    Location:216 → 306
    ig; Immunoglobulin domain
    pfam07714
    Location:590 → 925
    Pkinase_Tyr; Protein tyrosine kinase
Nucleotide Protein
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