Format

Send to:

Choose Destination

Kit KIT proto-oncogene receptor tyrosine kinase [ Mus musculus (house mouse) ]

Gene ID: 16590, updated on 8-Dec-2018

Summary

Official Symbol
Kitprovided by MGI
Official Full Name
KIT proto-oncogene receptor tyrosine kinaseprovided by MGI
Primary source
MGI:MGI:96677
See related
Ensembl:ENSMUSG00000005672
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
W; Bs; Fdc; Ssm; SCO1; SCO5; SOW3; CD117; c-KIT; Tr-kit; Gsfsco1; Gsfsco5; Gsfsow3
Summary
The c-Kit proto-oncogene is the cellular homolog of the transforming gene of a feline retrovirus (v-Kit). The c-kit protein includes characteristics of a protein kinase transmembrane receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Broad expression in lung adult (RPKM 39.0), cerebellum adult (RPKM 19.6) and 25 other tissues See more
Orthologs

Genomic context

See Kit in Genome Data Viewer
Location:
5 C3.3; 5 39.55 cM
Exon count:
22
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (75574987..75656722)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (75971012..76052747)

Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene platelet derived growth factor receptor, alpha polypeptide Neighboring gene microRNA 7025 Neighboring gene sterol O-acyltransferase 1 pseudogene Neighboring gene predicted gene, 32558 Neighboring gene predicted gene, 32727 Neighboring gene kinase insert domain protein receptor

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
cytokine binding ISO
Inferred from Sequence Orthology
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protease binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
stem cell factor receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmembrane receptor protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
B cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Fc receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Kit signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Kit signaling pathway ISO
Inferred from Sequence Orthology
more info
 
T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
actin cytoskeleton reorganization ISO
Inferred from Sequence Orthology
more info
 
activation of MAPK activity ISO
Inferred from Sequence Orthology
more info
 
cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
cell differentiation TAS
Traceable Author Statement
more info
PubMed 
cellular response to thyroid hormone stimulus IDA
Inferred from Direct Assay
more info
PubMed 
chemotaxis TAS
Traceable Author Statement
more info
PubMed 
cytokine-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
dendritic cell cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
detection of mechanical stimulus involved in sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
PubMed 
developmental pigmentation IMP
Inferred from Mutant Phenotype
more info
PubMed 
digestive tract development IMP
Inferred from Mutant Phenotype
more info
PubMed 
ectopic germ cell programmed cell death IGI
Inferred from Genetic Interaction
more info
PubMed 
embryonic hemopoiesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
erythrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
erythrocyte differentiation TAS
Traceable Author Statement
more info
PubMed 
erythropoietin-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
germ cell development TAS
Traceable Author Statement
more info
PubMed 
germ cell migration ISO
Inferred from Sequence Orthology
more info
 
glycosphingolipid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
hematopoietic progenitor cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
hematopoietic stem cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
hemopoiesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
immature B cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
lamellipodium assembly IDA
Inferred from Direct Assay
more info
PubMed 
lymphoid progenitor cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
mast cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
mast cell cytokine production ISO
Inferred from Sequence Orthology
more info
 
mast cell degranulation ISO
Inferred from Sequence Orthology
more info
 
mast cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
megakaryocyte development IMP
Inferred from Mutant Phenotype
more info
PubMed 
melanocyte adhesion IDA
Inferred from Direct Assay
more info
PubMed 
melanocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
melanocyte migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
myeloid leukocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
myeloid progenitor cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of programmed cell death IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of programmed cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
ovarian follicle development IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
pigmentation IGI
Inferred from Genetic Interaction
more info
PubMed 
pigmentation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of JAK-STAT cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of JAK-STAT cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of MAP kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of MAP kinase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of colon smooth muscle contraction ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of long-term neuronal synaptic plasticity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of pseudopodium assembly ISO
Inferred from Sequence Orthology
more info
 
positive regulation of pyloric antrum smooth muscle contraction ISO
Inferred from Sequence Orthology
more info
 
positive regulation of small intestine smooth muscle contraction ISO
Inferred from Sequence Orthology
more info
 
positive regulation of tyrosine phosphorylation of STAT protein ISO
Inferred from Sequence Orthology
more info
 
positive regulation of vascular smooth muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein autophosphorylation TAS
Traceable Author Statement
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of bile acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
regulation of cell shape IDA
Inferred from Direct Assay
more info
PubMed 
regulation of developmental pigmentation IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of developmental pigmentation IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to radiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
somatic stem cell division ISO
Inferred from Sequence Orthology
more info
 
somatic stem cell population maintenance ISO
Inferred from Sequence Orthology
more info
 
spermatid development IMP
Inferred from Mutant Phenotype
more info
PubMed 
spermatogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
spermatogenesis ISO
Inferred from Sequence Orthology
more info
 
stem cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
visual learning ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
acrosomal vesicle ISO
Inferred from Sequence Orthology
more info
 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
mast/stem cell growth factor receptor Kit
Names
Dominant white spotting
SCFR
Steel Factor Receptor
belly-spot
c-kit proto-oncogene protein
dominant spotting
kit oncogene
proto-oncogene c-Kit
proto-oncogene tyrosine-protein kinase Kit
spotted sterile male
tyrosine-protein kinase Kit
NP_001116205.1
NP_066922.2
XP_017176176.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001122733.1NP_001116205.1  mast/stem cell growth factor receptor Kit isoform 1 precursor

    See identical proteins and their annotated locations for NP_001116205.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK047010, BC052457, BY123520
    Consensus CDS
    CCDS51525.1
    UniProtKB/Swiss-Prot
    P05532
    Related
    ENSMUSP00000005815.6, ENSMUST00000005815.6
    Conserved Domains (6) summary
    cd05860
    Location:314414
    Ig4_SCFR; Fourth immunoglobulin (Ig)-like domain of stem cell factor receptor (SCFR)
    smart00410
    Location:221310
    IG_like; Immunoglobulin like
    cd05104
    Location:556930
    PTKc_Kit; Catalytic domain of the Protein Tyrosine Kinase, Kit
    pfam00047
    Location:217308
    ig; Immunoglobulin domain
    pfam07714
    Location:592926
    Pkinase_Tyr; Protein tyrosine kinase
    cl11960
    Location:427501
    Ig; Immunoglobulin domain
  2. NM_021099.3NP_066922.2  mast/stem cell growth factor receptor Kit isoform 2 precursor

    See identical proteins and their annotated locations for NP_066922.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate splice site in the CDS and encodes a shorter isoform, as compared to variant 1.
    Source sequence(s)
    AY536430, BC052457, BY017579
    Consensus CDS
    CCDS80302.1
    UniProtKB/Swiss-Prot
    P05532
    Related
    ENSMUSP00000116465.2, ENSMUST00000144270.7
    Conserved Domains (6) summary
    cd05860
    Location:314414
    Ig4_SCFR; Fourth immunoglobulin (Ig)-like domain of stem cell factor receptor (SCFR)
    smart00410
    Location:221310
    IG_like; Immunoglobulin like
    cd05104
    Location:552926
    PTKc_Kit; Catalytic domain of the Protein Tyrosine Kinase, Kit
    pfam00047
    Location:217308
    ig; Immunoglobulin domain
    pfam07714
    Location:588922
    Pkinase_Tyr; Protein tyrosine kinase
    cl11960
    Location:427501
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

    Range
    75574987..75656722
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017320687.1XP_017176176.1  mast/stem cell growth factor receptor Kit isoform X1

Support Center