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Kit KIT proto-oncogene receptor tyrosine kinase [ Mus musculus (house mouse) ]

Gene ID: 16590, updated on 21-Oct-2021

Summary

Official Symbol
Kitprovided by MGI
Official Full Name
KIT proto-oncogene receptor tyrosine kinaseprovided by MGI
Primary source
MGI:MGI:96677
See related
Ensembl:ENSMUSG00000005672
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
W; Bs; Fdc; Ssm; SCO1; SCO5; SOW3; CD117; c-KIT; Tr-kit; Gsfsco1; Gsfsco5; Gsfsow3
Summary
The c-Kit proto-oncogene is the cellular homolog of the transforming gene of a feline retrovirus (v-Kit). The c-kit protein includes characteristics of a protein kinase transmembrane receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Broad expression in lung adult (RPKM 39.0), cerebellum adult (RPKM 19.6) and 25 other tissues See more
Orthologs
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Genomic context

See Kit in Genome Data Viewer
Location:
5 C3.3; 5 39.55 cM
Exon count:
21
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (75735647..75817382)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (75574987..75656722)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (75971012..76052747)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene sterol O-acyltransferase 1 pseudogene Neighboring gene predicted gene, 24502 Neighboring gene predicted gene, 32558 Neighboring gene predicted gene, 54290

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables SH2 domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables cytokine binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protease binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables stem cell factor receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transmembrane receptor protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in B cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in Fc receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in Kit signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in Kit signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in actin cytoskeleton reorganization ISO
Inferred from Sequence Orthology
more info
 
involved_in cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell differentiation TAS
Traceable Author Statement
more info
PubMed 
involved_in cellular response to thyroid hormone stimulus IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within chemotaxis TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within cytokine-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in detection of mechanical stimulus involved in sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within developmental pigmentation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within developmental pigmentation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in digestive tract development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within ectopic germ cell programmed cell death IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in embryonic hemopoiesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in erythrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_negative_effect erythrocyte differentiation TAS
Traceable Author Statement
more info
PubMed 
involved_in erythropoietin-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within germ cell development TAS
Traceable Author Statement
more info
PubMed 
involved_in germ cell migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within glycosphingolipid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in hematopoietic progenitor cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within hematopoietic stem cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hemopoiesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in immature B cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in lamellipodium assembly IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within lymphoid progenitor cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in mast cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in mast cell degranulation ISO
Inferred from Sequence Orthology
more info
 
involved_in mast cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in megakaryocyte development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in melanocyte adhesion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in melanocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in melanocyte migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within myeloid leukocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within myeloid progenitor cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of programmed cell death IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of programmed cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ovarian follicle development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within pigmentation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in pigmentation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of MAP kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within positive regulation of MAP kinase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of colon smooth muscle contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of dendritic cell cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of long-term neuronal synaptic plasticity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mast cell cytokine production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of pseudopodium assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of pyloric antrum smooth muscle contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of receptor signaling pathway via JAK-STAT IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of receptor signaling pathway via JAK-STAT ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of small intestine smooth muscle contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of tyrosine phosphorylation of STAT protein ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vascular associated smooth muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein autophosphorylation TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of bile acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell shape IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within response to radiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in somatic stem cell division ISO
Inferred from Sequence Orthology
more info
 
involved_in somatic stem cell population maintenance ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within spermatid development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in spermatogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in stem cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in visual learning ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in acrosomal vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
mast/stem cell growth factor receptor Kit
Names
Dominant white spotting
SCFR
Steel Factor Receptor
belly-spot
c-kit proto-oncogene protein
dominant spotting
kit oncogene
proto-oncogene c-Kit
proto-oncogene tyrosine-protein kinase Kit
spotted sterile male
tyrosine-protein kinase Kit
NP_001116205.1
NP_066922.2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001122733.1NP_001116205.1  mast/stem cell growth factor receptor Kit isoform 1 precursor

    See identical proteins and their annotated locations for NP_001116205.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK047010, BC052457, BY123520
    Consensus CDS
    CCDS51525.1
    UniProtKB/Swiss-Prot
    P05532
    Related
    ENSMUSP00000005815.7, ENSMUST00000005815.7
    Conserved Domains (6) summary
    cd05860
    Location:314414
    Ig4_SCFR; Fourth immunoglobulin (Ig)-like domain of stem cell factor receptor (SCFR)
    smart00410
    Location:221310
    IG_like; Immunoglobulin like
    cd05104
    Location:556930
    PTKc_Kit; Catalytic domain of the Protein Tyrosine Kinase, Kit
    pfam00047
    Location:217308
    ig; Immunoglobulin domain
    pfam07714
    Location:592926
    Pkinase_Tyr; Protein tyrosine kinase
    cl11960
    Location:427501
    Ig; Immunoglobulin domain
  2. NM_021099.3NP_066922.2  mast/stem cell growth factor receptor Kit isoform 2 precursor

    See identical proteins and their annotated locations for NP_066922.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate splice site in the CDS and encodes a shorter isoform, as compared to variant 1.
    Source sequence(s)
    AY536430, BC052457, BY017579
    Consensus CDS
    CCDS80302.1
    UniProtKB/Swiss-Prot
    P05532
    Related
    ENSMUSP00000116465.3, ENSMUST00000144270.8
    Conserved Domains (6) summary
    cd05860
    Location:314414
    Ig4_SCFR; Fourth immunoglobulin (Ig)-like domain of stem cell factor receptor (SCFR)
    smart00410
    Location:221310
    IG_like; Immunoglobulin like
    cd05104
    Location:552926
    PTKc_Kit; Catalytic domain of the Protein Tyrosine Kinase, Kit
    pfam00047
    Location:217308
    ig; Immunoglobulin domain
    pfam07714
    Location:588922
    Pkinase_Tyr; Protein tyrosine kinase
    cl11960
    Location:427501
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    75735647..75817382
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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