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ADAM10 ADAM metallopeptidase domain 10 [ Homo sapiens (human) ]

Gene ID: 102, updated on 21-Jan-2020

Summary

Official Symbol
ADAM10provided by HGNC
Official Full Name
ADAM metallopeptidase domain 10provided by HGNC
Primary source
HGNC:HGNC:188
See related
Ensembl:ENSG00000137845 MIM:602192
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RAK; kuz; AD10; AD18; MADM; CD156c; CDw156; HsT18717
Summary
Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin. Alternate splicing results in multiple transcript variants encoding different proteins that may undergo similar processing. [provided by RefSeq, Feb 2016]
Expression
Ubiquitous expression in urinary bladder (RPKM 30.9), thyroid (RPKM 26.8) and 25 other tissues See more
Orthologs

Genomic context

See ADAM10 in Genome Data Viewer
Location:
15q21.3
Exon count:
17
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (58588809..58749707, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (58887403..59042177, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 459 Neighboring gene lipase C, hepatic type Neighboring gene LIPC antisense RNA 1 Neighboring gene G protein subunit gamma 10 pseudogene Neighboring gene high mobility group box 1 pseudogene 51 Neighboring gene heat shock protein 90 alpha family class B member 4, pseudogene Neighboring gene RN7SK pseudogene 95 Neighboring gene ATP synthase membrane subunit g pseudogene Neighboring gene small nucleolar RNA, C/D box 3 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infected clinical samples have plasma extracellular vesicles that contain elevated ADAM10, ADAM17, and TNF when compared to healthy donors PubMed
Knockdown of ADAM metallopeptidase domain 10 (ADAM10) by siRNA inhibits HIV-1 replication in CD4+ T lymphocytes PubMed
Knockdown of ADAM metallopeptidase domain 10 (ADAM10) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with ADAM10; predicted interaction to be relevant to viral egress at plasma membrane/extracellular matrix PubMed
Nef nef HIV-1 Nef associates with ADAM10 in extracellular vesicles isolated from HIV-1-infected patients PubMed
Pr55(Gag) gag Treatment of PBMCs taken from treatment-naive HIV chronically infected individuals with a HIV-1 Gag peptide pool in the presence of ADAM10 inhibitor upregulates the levels of Tim-3 and IFN-gamma in CD8+ T cells PubMed
integrase gag-pol HIV-1 IN co-localizes and co-immunoprecipitates with ADAM10 in U373 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
SH3 domain binding IEA
Inferred from Electronic Annotation
more info
 
endopeptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
endopeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
integrin binding NAS
Non-traceable Author Statement
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
metalloendopeptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
metalloendopeptidase activity NAS
Non-traceable Author Statement
more info
PubMed 
metalloendopeptidase activity involved in amyloid precursor protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
metallopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
metallopeptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
metallopeptidase activity TAS
Traceable Author Statement
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein kinase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
signaling receptor binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
Notch receptor processing, ligand-dependent TAS
Traceable Author Statement
more info
 
Notch signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
PMA-inducible membrane protein ectodomain proteolysis IMP
Inferred from Mutant Phenotype
more info
PubMed 
amyloid precursor protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
amyloid-beta formation IEA
Inferred from Electronic Annotation
more info
 
cell-cell signaling NAS
Non-traceable Author Statement
more info
PubMed 
cellular protein metabolic process TAS
Traceable Author Statement
more info
 
cochlea development IEA
Inferred from Electronic Annotation
more info
 
constitutive protein ectodomain proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
extracellular matrix disassembly TAS
Traceable Author Statement
more info
 
in utero embryonic development ISS
Inferred from Sequence or Structural Similarity
more info
 
integrin-mediated signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
membrane protein ectodomain proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
membrane protein ectodomain proteolysis IMP
Inferred from Mutant Phenotype
more info
PubMed 
monocyte activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell adhesion NAS
Non-traceable Author Statement
more info
PubMed 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
pore complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of T cell chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
post-translational protein modification TAS
Traceable Author Statement
more info
 
postsynapse organization IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
protein processing IEA
Inferred from Electronic Annotation
more info
 
regulation of Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
regulation of dendritic spine morphogenesis IEA
Inferred from Electronic Annotation
more info
 
regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IEA
Inferred from Electronic Annotation
more info
 
regulation of vasculature development IEA
Inferred from Electronic Annotation
more info
 
response to antineoplastic agent IEA
Inferred from Electronic Annotation
more info
 
response to tumor necrosis factor IDA
Inferred from Direct Assay
more info
PubMed 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
toxin transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
Golgi-associated vesicle IDA
Inferred from Direct Assay
more info
PubMed 
axon IEA
Inferred from Electronic Annotation
more info
 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
clathrin-coated vesicle IEA
Inferred from Electronic Annotation
more info
 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
dendritic spine IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
focal adhesion HDA PubMed 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
membrane HDA PubMed 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
perinuclear endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 
plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
pore complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
postsynaptic density IEA
Inferred from Electronic Annotation
more info
 
postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
specific granule membrane TAS
Traceable Author Statement
more info
 
synaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
synaptic vesicle IEA
Inferred from Electronic Annotation
more info
 
tertiary granule membrane TAS
Traceable Author Statement
more info
 
tetraspanin-enriched microdomain IDA
Inferred from Direct Assay
more info
PubMed 
trans-Golgi network IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
disintegrin and metalloproteinase domain-containing protein 10
Names
a disintegrin and metalloprotease domain 10
kuzbanian protein homolog
mammalian disintegrin-metalloprotease
NP_001101.1
NP_001307499.1
XP_024305586.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033876.2 RefSeqGene

    Range
    5001..165899
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001110.4NP_001101.1  disintegrin and metalloproteinase domain-containing protein 10 isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_001101.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AA243020, AC018904, AF009615, AY726599, BE327886, BX372217, DA941750
    Consensus CDS
    CCDS10167.1
    UniProtKB/Swiss-Prot
    O14672
    UniProtKB/TrEMBL
    A0A024R5U5
    Related
    ENSP00000260408.3, ENST00000260408.8
    Conserved Domains (3) summary
    smart00050
    Location:466545
    DISIN; Homologues of snake disintegrins
    cd04270
    Location:220459
    ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.
    pfam01562
    Location:48141
    Pep_M12B_propep; Reprolysin family propeptide
  2. NM_001320570.2NP_001307499.1  disintegrin and metalloproteinase domain-containing protein 10 isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon compared to variant 1. The encoded isoform (2) is shorter than isoform 1. This isoform (2) may undergo proteolytic processing similar to isoform 1.
    Source sequence(s)
    AC018904, AC091046
    Conserved Domains (3) summary
    smart00050
    Location:435514
    DISIN; Homologues of snake disintegrins
    cd04270
    Location:220428
    ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.
    pfam01562
    Location:48141
    Pep_M12B_propep; Reprolysin family propeptide

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    58588809..58749707 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024449818.1XP_024305586.1  disintegrin and metalloproteinase domain-containing protein 10 isoform X1

    Conserved Domains (2) summary
    smart00050
    Location:392471
    DISIN; Homologues of snake disintegrins
    cd04270
    Location:146385
    ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.
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