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Adam10 a disintegrin and metallopeptidase domain 10 [ Mus musculus (house mouse) ]

Gene ID: 11487, updated on 8-Feb-2024

Summary

Official Symbol
Adam10provided by MGI
Official Full Name
a disintegrin and metallopeptidase domain 10provided by MGI
Primary source
MGI:MGI:109548
See related
Ensembl:ENSMUSG00000054693 AllianceGenome:MGI:109548
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
kuz; MADM; kuzbanian; 1700031C13Rik
Summary
This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. The encoded preproprotein undergoes proteolytic processing to generate a mature enzyme that is involved in the proteolytic release of membrane-bound proteins in a process called ectodomain shedding. Mice lacking the encoded protein die in utero with multiple defects of the developing central nervous system, somites, and cardiovascular system. [provided by RefSeq, May 2016]
Expression
Ubiquitous expression in liver E14 (RPKM 28.0), liver E14.5 (RPKM 23.2) and 27 other tissues See more
Orthologs
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Genomic context

See Adam10 in Genome Data Viewer
Location:
9 D; 9 39.53 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (70586133..70687511)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (70678944..70780229)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene MINDY lysine 48 deubiquitinase 2 Neighboring gene STARR-positive B cell enhancer ABC_E2903 Neighboring gene predicted gene 10642 Neighboring gene predicted gene, 31872 Neighboring gene cytochrome c, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_24559 Neighboring gene STARR-seq mESC enhancer starr_24560 Neighboring gene VISTA enhancer mm190 Neighboring gene lipase, hepatic Neighboring gene ribosomal RNA processing 7 homolog A pseudogene Neighboring gene STARR-seq mESC enhancer starr_24562 Neighboring gene STARR-seq mESC enhancer starr_24564 Neighboring gene predicted gene, 32017

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SH2 domain binding NAS
Non-traceable Author Statement
more info
PubMed 
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
 
enables endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables endopeptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metallodipeptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables metalloendopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables metalloendopeptidase activity TAS
Traceable Author Statement
more info
 
enables metalloendopeptidase activity involved in amyloid precursor protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metalloendopeptidase activity involved in amyloid precursor protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
enables metallopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables metallopeptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables metallopeptidase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in Notch receptor processing NAS
Non-traceable Author Statement
more info
PubMed 
involved_in Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in adherens junction organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in amyloid precursor protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in amyloid-beta formation ISO
Inferred from Sequence Orthology
more info
 
involved_in cochlea development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in constitutive protein ectodomain proteolysis ISO
Inferred from Sequence Orthology
more info
 
involved_in epidermal growth factor receptor ligand maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in membrane protein ectodomain proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in membrane protein ectodomain proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in membrane protein ectodomain proteolysis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within membrane protein ectodomain proteolysis ISO
Inferred from Sequence Orthology
more info
 
involved_in monocyte activation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in nucleocytoplasmic transport NAS
Non-traceable Author Statement
more info
PubMed 
involved_in pore complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in pore complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of T cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in postsynapse organization EXP
Inferred from Experiment
more info
PubMed 
involved_in postsynapse organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein catabolic process at postsynapse EXP
Inferred from Experiment
more info
PubMed 
involved_in protein catabolic process at postsynapse IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein catabolic process at postsynapse IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in protein catabolic process at postsynapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within protein processing IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of dendritic spine morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane EXP
Inferred from Experiment
more info
PubMed 
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of postsynapse organization EXP
Inferred from Experiment
more info
PubMed 
involved_in regulation of postsynapse organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of postsynapse organization IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in regulation of postsynapse organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of vasculature development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to tumor necrosis factor ISO
Inferred from Sequence Orthology
more info
 
involved_in signaling receptor ligand precursor processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in signaling receptor ligand precursor processing ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in toxin transport ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in Golgi-associated vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in collagen-containing extracellular matrix HDA PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IEP
Inferred from Expression Pattern
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
part_of pore complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
part_of pore complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
 
located_in postsynapse ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in synaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in synaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in synaptic membrane ISO
Inferred from Sequence Orthology
more info
 
located_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in tetraspanin-enriched microdomain ISO
Inferred from Sequence Orthology
more info
 
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
disintegrin and metalloproteinase domain-containing protein 10
Names
a disintegrin and metalloprotease domain (ADAM) 10
kuzbanian protein homolog
mammalian disintegrin-metalloprotease
NP_031425.2
XP_030099887.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007399.4NP_031425.2  disintegrin and metalloproteinase domain-containing protein 10 preproprotein

    See identical proteins and their annotated locations for NP_031425.2

    Status: REVIEWED

    Source sequence(s)
    AC160636, AK031857, BC057346, BC066207, BE654195, BY205591
    Consensus CDS
    CCDS23323.1
    UniProtKB/Swiss-Prot
    B8JJJ0, O35598
    Related
    ENSMUSP00000063839.7, ENSMUST00000067880.13
    Conserved Domains (4) summary
    smart00050
    Location:467546
    DISIN; Homologues of snake disintegrins
    cd04270
    Location:221460
    ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.
    pfam01562
    Location:46146
    Pep_M12B_propep; Reprolysin family propeptide
    pfam13574
    Location:241445
    Reprolysin_2; Metallo-peptidase family M12B Reprolysin-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    70586133..70687511
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030244027.2XP_030099887.1  disintegrin and metalloproteinase domain-containing protein 10 isoform X1

    Conserved Domains (2) summary
    smart00050
    Location:393472
    DISIN; Homologues of snake disintegrins
    cd04270
    Location:147386
    ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.