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ZNF256 zinc finger protein 256 [ Homo sapiens (human) ]

Gene ID: 10172, updated on 25-Jan-2022

Summary

Official Symbol
ZNF256provided by HGNC
Official Full Name
zinc finger protein 256provided by HGNC
Primary source
HGNC:HGNC:13049
See related
Ensembl:ENSG00000152454 MIM:606956; AllianceGenome:HGNC:13049
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BMZF3; BMZF-3
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription, DNA-templated. Located in nucleoplasm. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Ubiquitous expression in bone marrow (RPKM 4.0), testis (RPKM 3.0) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF256 in Genome Data Viewer
Location:
19q13.43
Exon count:
3
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (57940833..57947706, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (58452201..58459074, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 417 Neighboring gene zinc finger protein 418 Neighboring gene ribosomal protein L19 pseudogene 19 Neighboring gene chromosome 19 open reading frame 18

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 256
Names
bone marrow zinc finger 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001375403.1NP_001362332.1  zinc finger protein 256 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC010326
    Conserved Domains (2) summary
    COG5048
    Location:140473
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:368388
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. NM_005773.3NP_005764.2  zinc finger protein 256 isoform 1

    See identical proteins and their annotated locations for NP_005764.2

    Status: VALIDATED

    Source sequence(s)
    AC010326
    Consensus CDS
    CCDS12966.1
    UniProtKB/Swiss-Prot
    Q9Y2P7
    Related
    ENSP00000282308.2, ENST00000282308.4
    Conserved Domains (3) summary
    COG5048
    Location:293626
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:521541
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:1454
    KRAB; KRAB box

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    57940833..57947706 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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