U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

SOS1 SOS Ras/Rac guanine nucleotide exchange factor 1 [ Trichechus manatus latirostris (Florida manatee) ]

Gene ID: 101359592, updated on 8-Mar-2024

Summary

Go to the top of the page Help
Gene symbol
SOS1
Gene description
SOS Ras/Rac guanine nucleotide exchange factor 1
See related
EnsemblRapid:ENSTMLG00000001475
Gene type
protein coding
RefSeq status
MODEL
Organism
Trichechus manatus latirostris (sub-species: latirostris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See SOS1 in Genome Data Viewer
Location:
chromosome: Un
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_01 current TriManLat1.0 (GCF_000243295.1) Unplaced Scaffold NW_004443941.1 (24274070..24447550)

NW_004443941.1Genomic Context describing neighboring genes Neighboring gene cyclin dependent kinase like 4 Neighboring gene dynein light chain roadblock-type 1 pseudogene Neighboring gene Rho guanine nucleotide exchange factor 33 Neighboring gene MORN repeat containing 2

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NW_004443941 Unplaced Scaffold Reference TriManLat1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Ras protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
son of sevenless homolog 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: GCF_000243295.1-RS_2024_01

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference TriManLat1.0 Primary Assembly

Genomic

  1. NW_004443941.1 Reference TriManLat1.0 Primary Assembly

    Range
    24274070..24447550
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_023735711.1 → XP_023591479.1  son of sevenless homolog 1 isoform X3

    UniProtKB/TrEMBL
    A0A2Y9RHT0
    Related
    ENSTMLP00000002075.1, ENSTMLT00000002259.1
    Conserved Domains (6) summary
    smart00229
    Location:553 → 697
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00155
    Location:732 → 971
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cd00160
    Location:157 → 344
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01261
    Location:395 → 501
    PH_SOS; Son of Sevenless (SOS) Pleckstrin homology (PH) domain
    cl23830
    Location:71 → 125
    Histone; Core histone H2A/H2B/H3/H4
    cl25751
    Location:974 → 1275
    DUF4045; Domain of unknown function (DUF4045)

  2. XM_004369538.2 → XP_004369595.1  son of sevenless homolog 1 isoform X1

    UniProtKB/TrEMBL
    A0A2Y9D7U3
    Related
    ENSTMLP00000002007.1, ENSTMLT00000002187.1
    Conserved Domains (6) summary
    smart00229
    Location:597 → 741
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00155
    Location:776 → 1015
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cd00160
    Location:201 → 388
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01261
    Location:439 → 545
    PH_SOS; Son of Sevenless (SOS) Pleckstrin homology (PH) domain
    pfam00169
    Location:445 → 546
    PH; PH domain
    cl23907
    Location:97 → 177
    H2A; Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding ...

  3. XM_012556736.2 → XP_012412190.1  son of sevenless homolog 1 isoform X2

    UniProtKB/TrEMBL
    A0A2Y9FY80
    Related
    ENSTMLP00000002039.1, ENSTMLT00000002222.1
    Conserved Domains (6) summary
    smart00229
    Location:597 → 741
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00155
    Location:776 → 1015
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cd00160
    Location:201 → 388
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01261
    Location:439 → 545
    PH_SOS; Son of Sevenless (SOS) Pleckstrin homology (PH) domain
    pfam00169
    Location:445 → 546
    PH; PH domain
    cl23907
    Location:97 → 177
    H2A; Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding ...

  4. XM_023735714.1 → XP_023591482.1  son of sevenless homolog 1 isoform X4

    UniProtKB/TrEMBL
    A0A2Y9RAK7
    Conserved Domains (5) summary
    smart00229
    Location:597 → 741
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00155
    Location:776 → 988
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cd00160
    Location:201 → 388
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01261
    Location:439 → 545
    PH_SOS; Son of Sevenless (SOS) Pleckstrin homology (PH) domain
    cl23830
    Location:69 → 169
    Histone; Core histone H2A/H2B/H3/H4
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.