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EGFR epidermal growth factor receptor [ Orcinus orca (killer whale) ]

Gene ID: 101275398, updated on 11-Apr-2024

Summary

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Gene symbol
EGFR
Gene description
epidermal growth factor receptor
See related
EnsemblRapid:ENSOORG00010003161
Gene type
protein coding
RefSeq status
MODEL
Organism
Orcinus orca
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti; Delphinidae; Orcinus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 9
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2023_02 current mOrcOrc1.1 (GCF_937001465.1) 9 NC_064567.1 (99076739..99269692, complement)

Chromosome 9 - NC_064567.1Genomic Context describing neighboring genes Neighboring gene mitochondrial intermembrane space import and assembly protein 40-like Neighboring gene uncharacterized LOC117197830 Neighboring gene uncharacterized LOC125965415 Neighboring gene uncharacterized LOC125965414 Neighboring gene U1 spliceosomal RNA Neighboring gene uncharacterized LOC117197834

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_064567.1 Chromosome 9 Reference mOrcOrc1.1 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables epidermal growth factor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables epidermal growth factor receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of epithelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in basal plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
epidermal growth factor receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_937001465.1-RS_2023_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mOrcOrc1.1 Primary Assembly

Genomic

  1. NC_064567.1 Reference mOrcOrc1.1 Primary Assembly

    Range
    99076739..99269692 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_033411328.2 → XP_033267219.1  epidermal growth factor receptor isoform X3

    Conserved Domains (4) summary
    cd05108
    Location:704 → 1016
    PTKc_EGFR; Catalytic domain of the Protein Tyrosine Kinase, Epidermal Growth Factor Receptor
    pfam00757
    Location:186 → 335
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:57 → 168
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:505 → 637
    GF_recep_IV; Growth factor receptor domain IV

  2. XM_004283008.3 → XP_004283056.1  epidermal growth factor receptor isoform X2

    Related
    ENSOORP00010003409.1, ENSOORT00010004425.1
    Conserved Domains (7) summary
    smart00219
    Location:712 → 968
    TyrKc; Tyrosine kinase, catalytic domain
    smart00261
    Location:552 → 598
    FU; Furin-like repeats
    cd00064
    Location:231 → 274
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    cd05108
    Location:704 → 1016
    PTKc_EGFR; Catalytic domain of the Protein Tyrosine Kinase, Epidermal Growth Factor Receptor
    pfam00757
    Location:186 → 335
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:361 → 481
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:505 → 637
    GF_recep_IV; Growth factor receptor domain IV

  3. XM_033411327.2 → XP_033267218.1  epidermal growth factor receptor isoform X1

    Conserved Domains (4) summary
    cd05108
    Location:704 → 1016
    PTKc_EGFR; Catalytic domain of the Protein Tyrosine Kinase, Epidermal Growth Factor Receptor
    pfam00757
    Location:186 → 335
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:57 → 168
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:505 → 637
    GF_recep_IV; Growth factor receptor domain IV

RNA

  1. XR_007479257.1 RNA Sequence

Nucleotide Protein
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